Early Neurotoxic Effects of Inorganic Arsenic Modulate Cortical GSH Levels Associated With the Activation of the Nrf2 and NFκB Pathways, Expression of Amino Acid Transporters and NMDA Receptors and the Production of Hydrogen Sulfide

Early Neurotoxic Effects of Inorganic Arsenic Modulate Cortical GSH Levels Associated With the Activation of the Nrf2 and NFκB Pathways, Expression of Amino Acid Transporters and NMDA Receptors and the Production of Hydrogen Sulfide

Exposure to toxic metals and metalloids is an important cause of preventable diseases worldwide. Inorganic arsenic (iAs) affects several organs and tissues, causing neurobehavioral alterations in the central nervous system (CNS) that might lead to neurodegeneration. In this work, we wanted to explor...

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Bibliographic Details
Main Authors: Daniela Silva-Adaya, Lucio Antonio Ramos-Chávez, Pavel Petrosyan, Wendy Leslie González-Alfonso, Alegna Pérez-Acosta, Maria E. Gonsebatt
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
arsenic
GSH
Nrf2
NFκB
CNS cysteine/glutamate transporters
H2S
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00017/full

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