Epigenetic age acceleration is associated with speed of pubertal growth but not age of pubertal onset
Abstract Using data from a longitudinal cohort of children, we examined whether epigenetic age acceleration (EAA) was associated with pubertal growth and whether these associations were mediated by adiposity. We examined associations between EAA at approximately 10 years of age with pubertal growth...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-53508-z |
| _version_ | 1797275066250035200 |
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| author | Catherine Kim Kylie K. Harrall Deborah H. Glueck Christine Hockett Dana Dabelea |
| author_facet | Catherine Kim Kylie K. Harrall Deborah H. Glueck Christine Hockett Dana Dabelea |
| author_sort | Catherine Kim |
| collection | DOAJ |
| description | Abstract Using data from a longitudinal cohort of children, we examined whether epigenetic age acceleration (EAA) was associated with pubertal growth and whether these associations were mediated by adiposity. We examined associations between EAA at approximately 10 years of age with pubertal growth metrics, including age at peak height velocity (PHV), PHV, and sex steroid levels and whether these associations were mediated by measures of adiposity including body mass index (BMI) and MRI-assessed visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). Children (n = 135) with accelerated EAA had higher PHV (β 0.018, p = 0.0008) although the effect size was small. The association between EAA and age at PHV was not significant (β − 0.0022, p = 0.067). Although EAA was associated with higher BMI (β 0.16, p = 0.0041), VAT (β 0.50, p = 0.037), and SAT (β 3.47, p = 0.0076), BMI and VAT did not mediate associations between EAA and PHV, while SAT explained 8.4% of the association. Boys with higher EAA had lower total testosterone (β − 12.03, p = 0.0014), but associations between EAA and other sex steroids were not significant, and EAA was not associated with sex steroid levels in girls. We conclude that EAA did not have strong associations with either age at onset of puberty or pubertal growth speed, although associations with growth speed were statistically significant. Studies with larger sample sizes are needed to confirm this pattern of associations. |
| first_indexed | 2024-03-07T15:08:05Z |
| format | Article |
| id | doaj.art-4c5c7be16e674e35804bda8f14db58ea |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:08:05Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4c5c7be16e674e35804bda8f14db58ea2024-03-05T18:48:21ZengNature PortfolioScientific Reports2045-23222024-02-011411910.1038/s41598-024-53508-zEpigenetic age acceleration is associated with speed of pubertal growth but not age of pubertal onsetCatherine Kim0Kylie K. Harrall1Deborah H. Glueck2Christine Hockett3Dana Dabelea4Departments of Medicine, Obstetrics & Gynecology, and Epidemiology, University of MichiganLifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado DenverLifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado DenverLifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado DenverLifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado DenverAbstract Using data from a longitudinal cohort of children, we examined whether epigenetic age acceleration (EAA) was associated with pubertal growth and whether these associations were mediated by adiposity. We examined associations between EAA at approximately 10 years of age with pubertal growth metrics, including age at peak height velocity (PHV), PHV, and sex steroid levels and whether these associations were mediated by measures of adiposity including body mass index (BMI) and MRI-assessed visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). Children (n = 135) with accelerated EAA had higher PHV (β 0.018, p = 0.0008) although the effect size was small. The association between EAA and age at PHV was not significant (β − 0.0022, p = 0.067). Although EAA was associated with higher BMI (β 0.16, p = 0.0041), VAT (β 0.50, p = 0.037), and SAT (β 3.47, p = 0.0076), BMI and VAT did not mediate associations between EAA and PHV, while SAT explained 8.4% of the association. Boys with higher EAA had lower total testosterone (β − 12.03, p = 0.0014), but associations between EAA and other sex steroids were not significant, and EAA was not associated with sex steroid levels in girls. We conclude that EAA did not have strong associations with either age at onset of puberty or pubertal growth speed, although associations with growth speed were statistically significant. Studies with larger sample sizes are needed to confirm this pattern of associations.https://doi.org/10.1038/s41598-024-53508-z |
| spellingShingle | Catherine Kim Kylie K. Harrall Deborah H. Glueck Christine Hockett Dana Dabelea Epigenetic age acceleration is associated with speed of pubertal growth but not age of pubertal onset Scientific Reports |
| title | Epigenetic age acceleration is associated with speed of pubertal growth but not age of pubertal onset |
| title_full | Epigenetic age acceleration is associated with speed of pubertal growth but not age of pubertal onset |
| title_fullStr | Epigenetic age acceleration is associated with speed of pubertal growth but not age of pubertal onset |
| title_full_unstemmed | Epigenetic age acceleration is associated with speed of pubertal growth but not age of pubertal onset |
| title_short | Epigenetic age acceleration is associated with speed of pubertal growth but not age of pubertal onset |
| title_sort | epigenetic age acceleration is associated with speed of pubertal growth but not age of pubertal onset |
| url | https://doi.org/10.1038/s41598-024-53508-z |
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