Study the expression level of beta 2 microglobulin gene on hepatitis C patients before and after treatment with interferon
This study has been carried out to evaluate the expression level of beta 2 microglobulin gene on patients infected by hepatitis C virus before and after treatment with interferon. The study included 117 hepatitis C patients comprising as 63 pre-treated patients, the range of age was between 20-...
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| Formaat: | Artikel |
| Taal: | Arabic |
| Gepubliceerd in: |
College of Science for Women, University of Baghdad
2012-09-01
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| Reeks: | Baghdad Science Journal |
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| Online toegang: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/1390 |
| _version_ | 1828377648798105600 |
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| author | Baghdad Science Journal |
| author_facet | Baghdad Science Journal |
| author_sort | Baghdad Science Journal |
| collection | DOAJ |
| description | This study has been carried out to evaluate the expression level of beta 2 microglobulin gene on patients infected by hepatitis C virus before and after treatment with interferon. The study included 117 hepatitis C patients comprising as 63 pre-treated patients, the range of age was between 20-65 year with a mean age of 48.12 ± 16.1 and 54 post-treated patients with age range was between 23-63 year with the mean of 46.1 ± 18.1. Also it was found that more than half of patients were located within third and fourth decade i.e. 30-49 year, with a percentage of 52.4% and 55.6 % for pre-treatment and post-treatment patients respectively. Moreover , regarding both groups, males are more than females with the ratio of ( 3.2:1) among pre-treatment group and 2:1 among post-treatment group. Further , It has been found that the concentration of ?2 microglobulin was (3.425±0.943mg/L) among pre-treatment group and (1.860±0.723 mg/L) among post-treatment group with significant correlation (P=0.05). Besides that , in the present study ,It has been found the concentration of ?2 microglobulin was decrease after treatment from (3.425±0.943 mg/L) to (1.860±0.723mg/L) which was statistically significant (P=0.05) , Thus ?2 microglobulin can be used as a supporting marker of responsiveness to treatment with interferon in hepatitis C patients as well as indicator for monitoring the disease progression. |
| first_indexed | 2024-04-14T08:15:24Z |
| format | Article |
| id | doaj.art-4c5d23fdad5e4af0b75b54c51b6eaf7d |
| institution | Directory Open Access Journal |
| issn | 2078-8665 2411-7986 |
| language | Arabic |
| last_indexed | 2024-04-14T08:15:24Z |
| publishDate | 2012-09-01 |
| publisher | College of Science for Women, University of Baghdad |
| record_format | Article |
| series | Baghdad Science Journal |
| spelling | doaj.art-4c5d23fdad5e4af0b75b54c51b6eaf7d2022-12-22T02:04:25ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862012-09-019310.21123/bsj.9.3.504-510Study the expression level of beta 2 microglobulin gene on hepatitis C patients before and after treatment with interferonBaghdad Science JournalThis study has been carried out to evaluate the expression level of beta 2 microglobulin gene on patients infected by hepatitis C virus before and after treatment with interferon. The study included 117 hepatitis C patients comprising as 63 pre-treated patients, the range of age was between 20-65 year with a mean age of 48.12 ± 16.1 and 54 post-treated patients with age range was between 23-63 year with the mean of 46.1 ± 18.1. Also it was found that more than half of patients were located within third and fourth decade i.e. 30-49 year, with a percentage of 52.4% and 55.6 % for pre-treatment and post-treatment patients respectively. Moreover , regarding both groups, males are more than females with the ratio of ( 3.2:1) among pre-treatment group and 2:1 among post-treatment group. Further , It has been found that the concentration of ?2 microglobulin was (3.425±0.943mg/L) among pre-treatment group and (1.860±0.723 mg/L) among post-treatment group with significant correlation (P=0.05). Besides that , in the present study ,It has been found the concentration of ?2 microglobulin was decrease after treatment from (3.425±0.943 mg/L) to (1.860±0.723mg/L) which was statistically significant (P=0.05) , Thus ?2 microglobulin can be used as a supporting marker of responsiveness to treatment with interferon in hepatitis C patients as well as indicator for monitoring the disease progression.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/1390"Key words: beta 2 microglobulin gene , Hepatitis C Virus, Interferon" |
| spellingShingle | Baghdad Science Journal Study the expression level of beta 2 microglobulin gene on hepatitis C patients before and after treatment with interferon Baghdad Science Journal "Key words: beta 2 microglobulin gene , Hepatitis C Virus, Interferon" |
| title | Study the expression level of beta 2 microglobulin gene on hepatitis C patients before and after treatment with interferon |
| title_full | Study the expression level of beta 2 microglobulin gene on hepatitis C patients before and after treatment with interferon |
| title_fullStr | Study the expression level of beta 2 microglobulin gene on hepatitis C patients before and after treatment with interferon |
| title_full_unstemmed | Study the expression level of beta 2 microglobulin gene on hepatitis C patients before and after treatment with interferon |
| title_short | Study the expression level of beta 2 microglobulin gene on hepatitis C patients before and after treatment with interferon |
| title_sort | study the expression level of beta 2 microglobulin gene on hepatitis c patients before and after treatment with interferon |
| topic | "Key words: beta 2 microglobulin gene , Hepatitis C Virus, Interferon" |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/1390 |
| work_keys_str_mv | AT baghdadsciencejournal studytheexpressionlevelofbeta2microglobulingeneonhepatitiscpatientsbeforeandaftertreatmentwithinterferon |