Eomes is sufficient to regulate IL-10 expression and cytotoxic effector molecules in murine CD4+ T cells

Eomes is sufficient to regulate IL-10 expression and cytotoxic effector molecules in murine CD4+ T cells

The T-box transcription factors T-bet and Eomesodermin regulate type 1 immune responses in innate and adaptive lymphocytes. T-bet is widely expressed in the immune system but was initially identified as the lineage-specifying transcription factor of Th1 CD4+ T cells, where it governs expression of t...

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Bibliographic Details
Main Authors: Benedikt Thelen, Vincent Schipperges, Paulina Knörlein, Jonas F. Hummel, Frederic Arnold, Laurence Kupferschmid, Christoph S. N. Klose, Sebastian J. Arnold, Melanie Boerries, Yakup Tanriver
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
CD4 T cell
Eomes
IL-10
Tr1
LCMV (lymphocytic choriomeningitis virus)
cytotoxcicity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1058267/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1058267/full

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