Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies
Meteorin-like, also known as Metrnl, Meteorin-β, Subfatin, and Cometin, is a novel secreted protein exerting pleiotropic effects on inflammation, immunology, and metabolism. Earlier research on this hormone focused on regulating energy expenditure and glucose homeostasis. Consequently, several studi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1098570/full |
| _version_ | 1797895473559764992 |
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| author | Zhuoqi Li Ziyu Gao Tao Sun Shipeng Zhang Shengnan Yang Meilin Zheng Hui Shen |
| author_facet | Zhuoqi Li Ziyu Gao Tao Sun Shipeng Zhang Shengnan Yang Meilin Zheng Hui Shen |
| author_sort | Zhuoqi Li |
| collection | DOAJ |
| description | Meteorin-like, also known as Metrnl, Meteorin-β, Subfatin, and Cometin, is a novel secreted protein exerting pleiotropic effects on inflammation, immunology, and metabolism. Earlier research on this hormone focused on regulating energy expenditure and glucose homeostasis. Consequently, several studies attempted to characterize the molecule mechanism of Metrnl in glucose metabolism and obesity-related disorders but reported contradictory clinical results. Recent studies gradually noticed its multiple protective functions in inflammatory immune regulations and cardiometabolic diseases, such as inducing macrophage activation, angiogenesis, tissue remodeling, bone formation, and preventing dyslipidemias. A comprehensive understanding of this novel protein is essential to identify its significance as a potential therapeutic drug or a biomarker of certain diseases. In this review, we present the current knowledge on the physiology of Metrnl and its roles in inflammation, immunology, and metabolism, including animal/cell interventional preclinical studies and human clinical studies. We also describe controversies regarding the data of circulation Metrnl in different disease states to determine its clinical application better. |
| first_indexed | 2024-04-10T07:27:24Z |
| format | Article |
| id | doaj.art-4c5ff4aab1fc4a90a6ec4be94b894559 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T07:27:24Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-4c5ff4aab1fc4a90a6ec4be94b8945592023-02-24T05:07:09ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.10985701098570Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studiesZhuoqi Li0Ziyu Gao1Tao Sun2Shipeng Zhang3Shengnan Yang4Meilin Zheng5Hui Shen6Department of Rheumatology and Immunology, The First Hospital of China Medical University, China Medical University, Shen Yang, ChinaDepartment of Thyroid Surgery, The First Hospital of China Medical University, China Medical University, Shen Yang, ChinaDepartment of Rheumatology and Immunology, The First Hospital of China Medical University, China Medical University, Shen Yang, ChinaDepartment of Rheumatology and Immunology, The First Hospital of China Medical University, China Medical University, Shen Yang, ChinaDepartment of Rheumatology and Immunology, The First Hospital of China Medical University, China Medical University, Shen Yang, ChinaDepartment of Rheumatology and Immunology, The First Hospital of China Medical University, China Medical University, Shen Yang, ChinaDepartment of Rheumatology and Immunology, The First Hospital of China Medical University, China Medical University, Shen Yang, ChinaMeteorin-like, also known as Metrnl, Meteorin-β, Subfatin, and Cometin, is a novel secreted protein exerting pleiotropic effects on inflammation, immunology, and metabolism. Earlier research on this hormone focused on regulating energy expenditure and glucose homeostasis. Consequently, several studies attempted to characterize the molecule mechanism of Metrnl in glucose metabolism and obesity-related disorders but reported contradictory clinical results. Recent studies gradually noticed its multiple protective functions in inflammatory immune regulations and cardiometabolic diseases, such as inducing macrophage activation, angiogenesis, tissue remodeling, bone formation, and preventing dyslipidemias. A comprehensive understanding of this novel protein is essential to identify its significance as a potential therapeutic drug or a biomarker of certain diseases. In this review, we present the current knowledge on the physiology of Metrnl and its roles in inflammation, immunology, and metabolism, including animal/cell interventional preclinical studies and human clinical studies. We also describe controversies regarding the data of circulation Metrnl in different disease states to determine its clinical application better.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1098570/fullMetrnlinflammationmetabolismimmunityboneheart |
| spellingShingle | Zhuoqi Li Ziyu Gao Tao Sun Shipeng Zhang Shengnan Yang Meilin Zheng Hui Shen Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies Frontiers in Immunology Metrnl inflammation metabolism immunity bone heart |
| title | Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies |
| title_full | Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies |
| title_fullStr | Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies |
| title_full_unstemmed | Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies |
| title_short | Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies |
| title_sort | meteorin like metrnl a novel secreted protein implicated in inflammation immunology and metabolism a comprehensive review of preclinical and clinical studies |
| topic | Metrnl inflammation metabolism immunity bone heart |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1098570/full |
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