Blood pressure and Alzheimer's disease: A review of meta-analysis
BackgroundAlzheimer's disease (AD) is a neurological disorder of unknown cause, resulting in the death of brain cells. Identifying some of the modifiable risk factors for AD could be crucial for primary prevention and could lead to a reduction in the incidence of AD.ObjectiveThis study aimed to...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.1065335/full |
| _version_ | 1828067193056657408 |
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| author | Olalla Sáiz-Vazquez Alicia Puente-Martínez Joaquín Pacheco-Bonrostro Silvia Ubillos-Landa |
| author_facet | Olalla Sáiz-Vazquez Alicia Puente-Martínez Joaquín Pacheco-Bonrostro Silvia Ubillos-Landa |
| author_sort | Olalla Sáiz-Vazquez |
| collection | DOAJ |
| description | BackgroundAlzheimer's disease (AD) is a neurological disorder of unknown cause, resulting in the death of brain cells. Identifying some of the modifiable risk factors for AD could be crucial for primary prevention and could lead to a reduction in the incidence of AD.ObjectiveThis study aimed to perform a meta-meta-analysis of studies in order to assess the effect of blood pressure (BP) on the diagnosis of AD.MethodThe search was restricted to meta-analyses assessing high systolic BP (SBP) and diastolic BP (DBP) and AD. We applied the PRISMA guidelines.ResultsA total of 214 studies were identified from major databases. Finally, five meta-analyses (52 studies) were analyzed in this review. Results confirm that high SBP is associated with AD. The exploration of parameters (sex, age, study design, region, and BP measurements) shows that only region significantly moderates the relationship between BP and AD. Asian people are those whose SBP levels >140 mmHg are associated with AD. BP is associated with AD in both people aged ≤65 years and those aged ≥65 years and in cross-sectional and longitudinal studies. In the case of DBP, only women are at a higher risk of AD, particularly when its levels are >90.ConclusionSBP is associated with both cerebrovascular disease and AD. Therefore, future studies should use other uncontrolled factors, such as cardiovascular diseases, diabetes, and stroke, to explain the relationship between SBP and AD. |
| first_indexed | 2024-04-10T23:42:29Z |
| format | Article |
| id | doaj.art-4c60b18cd74b40b98fad0e4e090ff076 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T23:42:29Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-4c60b18cd74b40b98fad0e4e090ff0762023-01-11T06:19:10ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-01-011310.3389/fneur.2022.10653351065335Blood pressure and Alzheimer's disease: A review of meta-analysisOlalla Sáiz-Vazquez0Alicia Puente-Martínez1Joaquín Pacheco-Bonrostro2Silvia Ubillos-Landa3Department of Occupational Therapy, Faculty of Health Science, University of Burgos, Burgos, SpainDepartment of Social Psychology and Anthropology, Faculty of Social Sciences, University of Salamanca (USAL), Salamanca, SpainDepartment of Applied Economy, Faculty of Economics and Business Sciences, University of Burgos, Burgos, SpainDepartment of Social Psychology, Faculty of Health Science, University of Burgos, Burgos, SpainBackgroundAlzheimer's disease (AD) is a neurological disorder of unknown cause, resulting in the death of brain cells. Identifying some of the modifiable risk factors for AD could be crucial for primary prevention and could lead to a reduction in the incidence of AD.ObjectiveThis study aimed to perform a meta-meta-analysis of studies in order to assess the effect of blood pressure (BP) on the diagnosis of AD.MethodThe search was restricted to meta-analyses assessing high systolic BP (SBP) and diastolic BP (DBP) and AD. We applied the PRISMA guidelines.ResultsA total of 214 studies were identified from major databases. Finally, five meta-analyses (52 studies) were analyzed in this review. Results confirm that high SBP is associated with AD. The exploration of parameters (sex, age, study design, region, and BP measurements) shows that only region significantly moderates the relationship between BP and AD. Asian people are those whose SBP levels >140 mmHg are associated with AD. BP is associated with AD in both people aged ≤65 years and those aged ≥65 years and in cross-sectional and longitudinal studies. In the case of DBP, only women are at a higher risk of AD, particularly when its levels are >90.ConclusionSBP is associated with both cerebrovascular disease and AD. Therefore, future studies should use other uncontrolled factors, such as cardiovascular diseases, diabetes, and stroke, to explain the relationship between SBP and AD.https://www.frontiersin.org/articles/10.3389/fneur.2022.1065335/fullAlzheimer's diseaseblood pressuresysto-diastolic hypertensionrisk factormeta-analysis |
| spellingShingle | Olalla Sáiz-Vazquez Alicia Puente-Martínez Joaquín Pacheco-Bonrostro Silvia Ubillos-Landa Blood pressure and Alzheimer's disease: A review of meta-analysis Frontiers in Neurology Alzheimer's disease blood pressure systo-diastolic hypertension risk factor meta-analysis |
| title | Blood pressure and Alzheimer's disease: A review of meta-analysis |
| title_full | Blood pressure and Alzheimer's disease: A review of meta-analysis |
| title_fullStr | Blood pressure and Alzheimer's disease: A review of meta-analysis |
| title_full_unstemmed | Blood pressure and Alzheimer's disease: A review of meta-analysis |
| title_short | Blood pressure and Alzheimer's disease: A review of meta-analysis |
| title_sort | blood pressure and alzheimer s disease a review of meta analysis |
| topic | Alzheimer's disease blood pressure systo-diastolic hypertension risk factor meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.1065335/full |
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