BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

Evidence suggests that β-amyloid (Aβ) peptide triggers a pathogenic cascade leading to neuronal loss in Alzheimer’s disease (AD). However, the causal link between Aβ and neuron death in vivo remains unclear since most animal models fail to recapitulate the dramatic cell loss observed in AD. We have...

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Bibliographic Details
Main Authors: Masuo Ohno, Sarah L. Cole, Marina Yasvoina, Jie Zhao, Martin Citron, Robert Berry, John F. Disterhoft, Robert Vassar
Format: Article
Language:English
Published: Elsevier 2007-04-01
Series:Neurobiology of Disease
Subjects:
Alzheimer’s disease
β-Amyloid (Aβ)
β-Secretase
BACE1 knockout
Tg6799
Gliosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106003172

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