Portal vein thrombosis: What is new?
Portal vein thrombosis (PVT) is one of the most common vascular disorders of the liver with significant morbidity and mortality. Large cohort studies have reported a global prevalence of 1%, but in some risk groups it can be up to 26%. Causes of PVT are cirrhosis, hepatobiliary malignancy, abdominal...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119307975 |
| _version_ | 1830133624032198656 |
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| author | María del Carmen Manzano-Robleda Beatriz Barranco-Fragoso Misael Uribe Nahum Méndez-Sánchez |
| author_facet | María del Carmen Manzano-Robleda Beatriz Barranco-Fragoso Misael Uribe Nahum Méndez-Sánchez |
| author_sort | María del Carmen Manzano-Robleda |
| collection | DOAJ |
| description | Portal vein thrombosis (PVT) is one of the most common vascular disorders of the liver with significant morbidity and mortality. Large cohort studies have reported a global prevalence of 1%, but in some risk groups it can be up to 26%. Causes of PVT are cirrhosis, hepatobiliary malignancy, abdominal infectious or inflammatory diseases, and myeloproliferative disorders. Most patients with PVT have a general risk factor. The natural history of PVT results in portal hypertension leading to splenomegaly and the formation of portosystemic collateral blood vessels and esophageal, gastric, duodenal, and jejunal varices. Diagnosis of PVT is made by imaging, mainly Doppler ultrasonography. According to its time of development, localization, pathophysiology, and evolution, PVT should be classified in every patient. Some clinical features such as cirrhosis, hepatocellular carcinoma, and hepatic transplantation are areas of special interest and are discussed in this review. The goal of treatment of acute PVT is to reconstruct the blocked veins. Endoscopic variceal ligation is safe and highly effective in patients with variceal bleeding caused by chronic PVT. In conclusion, PVT is the most common cause of vascular disease of the liver and its prevalence has being increasing, especially among patients with an underlying liver disease. All patients should be investigated for thrombophilic conditions, and in those with cirrhosis, anticoagulation prophylaxis should be considered. |
| first_indexed | 2024-12-17T06:57:47Z |
| format | Article |
| id | doaj.art-4c61d50dc5d84a9e803212999f3bfe69 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-17T06:57:47Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-4c61d50dc5d84a9e803212999f3bfe692022-12-21T21:59:23ZengElsevierAnnals of Hepatology1665-26812015-01-011412027Portal vein thrombosis: What is new?María del Carmen Manzano-Robleda0Beatriz Barranco-Fragoso1Misael Uribe2Nahum Méndez-Sánchez3Liver Research Unit. Medica Sur Clinic & Foundation. Mexico City, MexicoDepartment of Gastroenterology, National Medical Center “20 Noviembre”. Mexico City. MexicoLiver Research Unit. Medica Sur Clinic & Foundation. Mexico City, MexicoLiver Research Unit. Medica Sur Clinic & Foundation. Mexico City, Mexico; Correspondence and reprint request:Portal vein thrombosis (PVT) is one of the most common vascular disorders of the liver with significant morbidity and mortality. Large cohort studies have reported a global prevalence of 1%, but in some risk groups it can be up to 26%. Causes of PVT are cirrhosis, hepatobiliary malignancy, abdominal infectious or inflammatory diseases, and myeloproliferative disorders. Most patients with PVT have a general risk factor. The natural history of PVT results in portal hypertension leading to splenomegaly and the formation of portosystemic collateral blood vessels and esophageal, gastric, duodenal, and jejunal varices. Diagnosis of PVT is made by imaging, mainly Doppler ultrasonography. According to its time of development, localization, pathophysiology, and evolution, PVT should be classified in every patient. Some clinical features such as cirrhosis, hepatocellular carcinoma, and hepatic transplantation are areas of special interest and are discussed in this review. The goal of treatment of acute PVT is to reconstruct the blocked veins. Endoscopic variceal ligation is safe and highly effective in patients with variceal bleeding caused by chronic PVT. In conclusion, PVT is the most common cause of vascular disease of the liver and its prevalence has being increasing, especially among patients with an underlying liver disease. All patients should be investigated for thrombophilic conditions, and in those with cirrhosis, anticoagulation prophylaxis should be considered.http://www.sciencedirect.com/science/article/pii/S1665268119307975Acute and chronic portal vein thrombosesLiver transplantationHepatocellular carcinomaCoagulationAnticoagulationCirrhosis |
| spellingShingle | María del Carmen Manzano-Robleda Beatriz Barranco-Fragoso Misael Uribe Nahum Méndez-Sánchez Portal vein thrombosis: What is new? Annals of Hepatology Acute and chronic portal vein thromboses Liver transplantation Hepatocellular carcinoma Coagulation Anticoagulation Cirrhosis |
| title | Portal vein thrombosis: What is new? |
| title_full | Portal vein thrombosis: What is new? |
| title_fullStr | Portal vein thrombosis: What is new? |
| title_full_unstemmed | Portal vein thrombosis: What is new? |
| title_short | Portal vein thrombosis: What is new? |
| title_sort | portal vein thrombosis what is new |
| topic | Acute and chronic portal vein thromboses Liver transplantation Hepatocellular carcinoma Coagulation Anticoagulation Cirrhosis |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119307975 |
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