Oleuropein alleviates myocardial ischemia–reperfusion injury by suppressing oxidative stress and excessive autophagy via TLR4/MAPK signaling pathway

Oleuropein alleviates myocardial ischemia–reperfusion injury by suppressing oxidative stress and excessive autophagy via TLR4/MAPK signaling pathway

Abstract Background Myocardial ischemia/reperfusion injury (MIRI) is an important complication of reperfusion therapy, and has a lack of effective prevention and treatment methods. Oleuropein (OP) is a natural strong antioxidant with many protective effects on cardiovascular diseases, but its protec...

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Bibliographic Details
Main Authors: Jia He, Liting Huang, Kaili Sun, Jilang Li, Shan Han, Xiang Gao, Qin-Qin Wang, Shilin Yang, Wen Sun, Hongwei Gao
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Chinese Medicine
Subjects:
Oleuropein
Myocardial ischemia–reperfusion
Oxidative stress
Autophagy
TLR4
MAPK
Online Access:https://doi.org/10.1186/s13020-024-00925-x

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