Challenging Diagnosis of Invasive Sinus Aspergillosis Mimicking Gradenigo’s Syndrome in an Elderly Patient with T-Cell Lymphoma
(1) Background: Gradenigo’s Syndrome (GS) is a rare complication of acute otitis media characterized by the triad of diplopia, otitis, and facial pain. The widespread use of antibiotics has significantly reduced its occurrence. (2) Case summary: We present the case of an elderly patient with T-cell...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Geriatrics |
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| Online Access: | https://www.mdpi.com/2308-3417/9/1/4 |
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| author | Victoria Ramos de Ascanio Gloria Liaño-Esteso David Roldán Teresa Collazo-Lorduy Sara Martínez-Flores José Ángel Hernández-Rivas Isabel González-Gascón-y-Marín |
| author_facet | Victoria Ramos de Ascanio Gloria Liaño-Esteso David Roldán Teresa Collazo-Lorduy Sara Martínez-Flores José Ángel Hernández-Rivas Isabel González-Gascón-y-Marín |
| author_sort | Victoria Ramos de Ascanio |
| collection | DOAJ |
| description | (1) Background: Gradenigo’s Syndrome (GS) is a rare complication of acute otitis media characterized by the triad of diplopia, otitis, and facial pain. The widespread use of antibiotics has significantly reduced its occurrence. (2) Case summary: We present the case of an elderly patient with T-cell lymphoma who developed neurological deficits resembling GS. The patient was ultimately diagnosed with invasive sinus aspergillosis. The diagnostic process was challenging due to the atypical clinical presentation and the lack of specific imaging findings. A biopsy was the most important test for clarifying the diagnosis. (3) Conclusions: The prognosis for this complication is extremely poor without surgery, and the patient died despite adequate antifungal coverage. Therefore, maintaining high clinical suspicion is paramount to avoid adverse outcomes in similar cases, particularly in the geriatric population, wherein this syndrome’s occurrence may not be expected. |
| first_indexed | 2024-03-07T22:30:29Z |
| format | Article |
| id | doaj.art-4c65af3098c54f6283c0dab97922d180 |
| institution | Directory Open Access Journal |
| issn | 2308-3417 |
| language | English |
| last_indexed | 2024-03-07T22:30:29Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Geriatrics |
| spelling | doaj.art-4c65af3098c54f6283c0dab97922d1802024-02-23T15:18:06ZengMDPI AGGeriatrics2308-34172023-12-0191410.3390/geriatrics9010004Challenging Diagnosis of Invasive Sinus Aspergillosis Mimicking Gradenigo’s Syndrome in an Elderly Patient with T-Cell LymphomaVictoria Ramos de Ascanio0Gloria Liaño-Esteso1David Roldán2Teresa Collazo-Lorduy3Sara Martínez-Flores4José Ángel Hernández-Rivas5Isabel González-Gascón-y-Marín6Hematology Department, Hospital Universitario Infanta Leonor, 28031 Madrid, SpainRadiology Department, Clínica Universidad de Navarra, 28031 Madrid, SpainPathology Department, Hospital Universitario Infanta Leonor, 28031 Madrid, SpainOtorhinolaryngology Department, Hospital Universitario Infanta Leonor, 28031 Madrid, SpainGeriatrics Department, Hospital Universitario Infanta Leonor, 28031 Madrid, SpainHematology Department, Hospital Universitario Infanta Leonor, 28031 Madrid, SpainHematology Department, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain(1) Background: Gradenigo’s Syndrome (GS) is a rare complication of acute otitis media characterized by the triad of diplopia, otitis, and facial pain. The widespread use of antibiotics has significantly reduced its occurrence. (2) Case summary: We present the case of an elderly patient with T-cell lymphoma who developed neurological deficits resembling GS. The patient was ultimately diagnosed with invasive sinus aspergillosis. The diagnostic process was challenging due to the atypical clinical presentation and the lack of specific imaging findings. A biopsy was the most important test for clarifying the diagnosis. (3) Conclusions: The prognosis for this complication is extremely poor without surgery, and the patient died despite adequate antifungal coverage. Therefore, maintaining high clinical suspicion is paramount to avoid adverse outcomes in similar cases, particularly in the geriatric population, wherein this syndrome’s occurrence may not be expected.https://www.mdpi.com/2308-3417/9/1/4T-cell lymphomainvasive aspergillosisfungal infectionimmunosuppressionelderly |
| spellingShingle | Victoria Ramos de Ascanio Gloria Liaño-Esteso David Roldán Teresa Collazo-Lorduy Sara Martínez-Flores José Ángel Hernández-Rivas Isabel González-Gascón-y-Marín Challenging Diagnosis of Invasive Sinus Aspergillosis Mimicking Gradenigo’s Syndrome in an Elderly Patient with T-Cell Lymphoma Geriatrics T-cell lymphoma invasive aspergillosis fungal infection immunosuppression elderly |
| title | Challenging Diagnosis of Invasive Sinus Aspergillosis Mimicking Gradenigo’s Syndrome in an Elderly Patient with T-Cell Lymphoma |
| title_full | Challenging Diagnosis of Invasive Sinus Aspergillosis Mimicking Gradenigo’s Syndrome in an Elderly Patient with T-Cell Lymphoma |
| title_fullStr | Challenging Diagnosis of Invasive Sinus Aspergillosis Mimicking Gradenigo’s Syndrome in an Elderly Patient with T-Cell Lymphoma |
| title_full_unstemmed | Challenging Diagnosis of Invasive Sinus Aspergillosis Mimicking Gradenigo’s Syndrome in an Elderly Patient with T-Cell Lymphoma |
| title_short | Challenging Diagnosis of Invasive Sinus Aspergillosis Mimicking Gradenigo’s Syndrome in an Elderly Patient with T-Cell Lymphoma |
| title_sort | challenging diagnosis of invasive sinus aspergillosis mimicking gradenigo s syndrome in an elderly patient with t cell lymphoma |
| topic | T-cell lymphoma invasive aspergillosis fungal infection immunosuppression elderly |
| url | https://www.mdpi.com/2308-3417/9/1/4 |
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