Essential trace metals in health and disease
Essential trace metals (Fe, Zn, Cu, Mn, Mo, Co) are involved in high number of physiological and metabolic activities and therefore have a substantial role in organisms. Thus, their balance is tightly regulated by levels of absorption, transport, and storage in the organism. They can alter human hea...
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| Format: | Article |
| Language: | English |
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University of Belgrade, Medical Faculty
2023-01-01
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| Series: | Medicinski Podmladak |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2023/0369-15272305001M.pdf |
| _version_ | 1827293585275355136 |
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| author | Makević Vedrana de Luka Silvio R. Ilić Anđelija |
| author_facet | Makević Vedrana de Luka Silvio R. Ilić Anđelija |
| author_sort | Makević Vedrana |
| collection | DOAJ |
| description | Essential trace metals (Fe, Zn, Cu, Mn, Mo, Co) are involved in high number of physiological and metabolic activities and therefore have a substantial role in organisms. Thus, their balance is tightly regulated by levels of absorption, transport, and storage in the organism. They can alter human health in both deficiency and overload conditions. On one hand, deficiency health problems are due to reduction of their physiological activities. On the other hand, Fe, Cu and Co are redox active metals and their increase can cause severe tissue damage through oxidative stress. Numerous well-established diseases like iron and copper deficiency anemia, hemochromatosis, Menkes and Wilson disease, acrodermatitis enteropathica are consequence of essential metal alterations. Nowadays, trace metals alterations are also found to be implicated in neurodegenerative disease, cancers, atherosclerosis, and diabetes. Those diseases represent enormous health problems in contemporary society and trace metals might help to further elucidate their pathogenesis and potentially even treatment. In the present study, essential trace metals kinetic and physiology are reviewed, as well as their roles in disease pathophysiology. |
| first_indexed | 2024-04-24T13:41:39Z |
| format | Article |
| id | doaj.art-4c65b94b20a24a43aaa419f53b683a13 |
| institution | Directory Open Access Journal |
| issn | 0369-1527 2466-5525 |
| language | English |
| last_indexed | 2024-04-24T13:41:39Z |
| publishDate | 2023-01-01 |
| publisher | University of Belgrade, Medical Faculty |
| record_format | Article |
| series | Medicinski Podmladak |
| spelling | doaj.art-4c65b94b20a24a43aaa419f53b683a132024-04-04T08:28:43ZengUniversity of Belgrade, Medical FacultyMedicinski Podmladak0369-15272466-55252023-01-017451810.5937/mp74-435730369-15272305001MEssential trace metals in health and diseaseMakević Vedrana0de Luka Silvio R.1https://orcid.org/0000-0002-0859-9252Ilić Anđelija2Univerzitet u Beogradu, Medicinski fakultet, Institut za patološku fiziologiju, Beograd, SerbiaUniverzitet u Beogradu, Medicinski fakultet, Institut za patološku fiziologiju, Beograd, SerbiaUniverzitet u Beogradu, Institut za fiziku, Beograd, SerbiaEssential trace metals (Fe, Zn, Cu, Mn, Mo, Co) are involved in high number of physiological and metabolic activities and therefore have a substantial role in organisms. Thus, their balance is tightly regulated by levels of absorption, transport, and storage in the organism. They can alter human health in both deficiency and overload conditions. On one hand, deficiency health problems are due to reduction of their physiological activities. On the other hand, Fe, Cu and Co are redox active metals and their increase can cause severe tissue damage through oxidative stress. Numerous well-established diseases like iron and copper deficiency anemia, hemochromatosis, Menkes and Wilson disease, acrodermatitis enteropathica are consequence of essential metal alterations. Nowadays, trace metals alterations are also found to be implicated in neurodegenerative disease, cancers, atherosclerosis, and diabetes. Those diseases represent enormous health problems in contemporary society and trace metals might help to further elucidate their pathogenesis and potentially even treatment. In the present study, essential trace metals kinetic and physiology are reviewed, as well as their roles in disease pathophysiology.https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2023/0369-15272305001M.pdfessential metalsmicroelementstoxicity |
| spellingShingle | Makević Vedrana de Luka Silvio R. Ilić Anđelija Essential trace metals in health and disease Medicinski Podmladak essential metals microelements toxicity |
| title | Essential trace metals in health and disease |
| title_full | Essential trace metals in health and disease |
| title_fullStr | Essential trace metals in health and disease |
| title_full_unstemmed | Essential trace metals in health and disease |
| title_short | Essential trace metals in health and disease |
| title_sort | essential trace metals in health and disease |
| topic | essential metals microelements toxicity |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2023/0369-15272305001M.pdf |
| work_keys_str_mv | AT makevicvedrana essentialtracemetalsinhealthanddisease AT delukasilvior essentialtracemetalsinhealthanddisease AT ilicanđelija essentialtracemetalsinhealthanddisease |