Oncogenic Activation of YAP Signaling Sensitizes Ferroptosis of Hepatocellular Carcinoma via ALOXE3-Mediated Lipid Peroxidation Accumulation

Oncogenic Activation of YAP Signaling Sensitizes Ferroptosis of Hepatocellular Carcinoma via ALOXE3-Mediated Lipid Peroxidation Accumulation

Ferroptosis, a form of programmed cell death process driven by iron-dependent lipid peroxidation, plays an important role in tumor suppression. Although previous study showed that intracellular Merlin-Hippo signaling suppresses ferroptosis of epithelial tumor cells through the inactivation of YAP si...

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Bibliographic Details
Main Authors: Yifei Qin, Zhuo Pei, Zhuan Feng, Peng Lin, Shijie Wang, Yong Li, Fei Huo, Quancheng Wang, Zhiping Wang, Zhi-Nan Chen, Jiao Wu, Yi-Fei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ferroptosis
YAP
ALOXE3
sorafenib
hepatocellular carcinoma
lipid peroxidation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.751593/full

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