Rate of Hospitalizations and Mortality of Respiratory Syncytial Virus Infection Compared to Influenza in Older People: A Systematic Review and Meta-Analysis
Respiratory Syncytial Virus (RSV) is commonly regarded as an infection typical of children, but increasing literature is showing its importance in older people. Since the data regarding the impact of RSV are still limited for older people, the aim of this systematic review and meta-analysis is to co...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/12/2092 |
| _version_ | 1827636646255788032 |
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| author | Stefania Maggi Nicola Veronese Marianna Burgio Giorgia Cammarata Maria Elena Ciuppa Stefano Ciriminna Francesco Di Gennaro Lee Smith Mike Trott Ligia J. Dominguez Giovanni M. Giammanco Simona De Grazia Claudio Costantino Francesco Vitale Mario Barbagallo |
| author_facet | Stefania Maggi Nicola Veronese Marianna Burgio Giorgia Cammarata Maria Elena Ciuppa Stefano Ciriminna Francesco Di Gennaro Lee Smith Mike Trott Ligia J. Dominguez Giovanni M. Giammanco Simona De Grazia Claudio Costantino Francesco Vitale Mario Barbagallo |
| author_sort | Stefania Maggi |
| collection | DOAJ |
| description | Respiratory Syncytial Virus (RSV) is commonly regarded as an infection typical of children, but increasing literature is showing its importance in older people. Since the data regarding the impact of RSV are still limited for older people, the aim of this systematic review and meta-analysis is to compare the rate of hospitalization and mortality between RSV and influenza in this population. A systematic literature search until 15 June 2022 was done across several databases and including studies reporting incidence rate and cumulative incidence of hospitalization and mortality in RSV and influenza affecting older people. Among 2295 records initially screened, 16 studies including 762,084 older participants were included. Compared to older patients having influenza, patients with RSV did not show any significant different risk in hospitalization (either cumulative or incidence rate). Similar results were evident for mortality. The quality of the studies was in general good. In conclusion, our systematic review and meta-analysis showed that the rate of hospitalization and mortality was similar between RSV and influenza in older adults, suggesting the importance of vaccination for RSV in older people for preventing negative outcomes, such as mortality and hospitalization. |
| first_indexed | 2024-03-09T15:45:40Z |
| format | Article |
| id | doaj.art-4c66aba0b8f340d09f54f82cec4c5d2f |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T15:45:40Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-4c66aba0b8f340d09f54f82cec4c5d2f2023-11-24T18:32:35ZengMDPI AGVaccines2076-393X2022-12-011012209210.3390/vaccines10122092Rate of Hospitalizations and Mortality of Respiratory Syncytial Virus Infection Compared to Influenza in Older People: A Systematic Review and Meta-AnalysisStefania Maggi0Nicola Veronese1Marianna Burgio2Giorgia Cammarata3Maria Elena Ciuppa4Stefano Ciriminna5Francesco Di Gennaro6Lee Smith7Mike Trott8Ligia J. Dominguez9Giovanni M. Giammanco10Simona De Grazia11Claudio Costantino12Francesco Vitale13Mario Barbagallo14Consiglio Nazionale delle Ricerche, Neuroscience Institute, 35100 Padova, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties “G. D’Alessandro”, University of Palermo, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties “G. D’Alessandro”, University of Palermo, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties “G. D’Alessandro”, University of Palermo, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties “G. D’Alessandro”, University of Palermo, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties “G. D’Alessandro”, University of Palermo, 90127 Palermo, ItalyDepartment of Biomedical Sciences and Human Oncology, Clinic of Infectious Diseases, University of Bari “Aldo Moro”, 70121 Bari, ItalyCentre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge CB1 1PT, UKCentre for Public Health, Queen’s University Belfast, Belfast BT12 6BA, UKDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties “G. D’Alessandro”, University of Palermo, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties “G. D’Alessandro”, University of Palermo, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties “G. D’Alessandro”, University of Palermo, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties “G. D’Alessandro”, University of Palermo, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties “G. D’Alessandro”, University of Palermo, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties “G. D’Alessandro”, University of Palermo, 90127 Palermo, ItalyRespiratory Syncytial Virus (RSV) is commonly regarded as an infection typical of children, but increasing literature is showing its importance in older people. Since the data regarding the impact of RSV are still limited for older people, the aim of this systematic review and meta-analysis is to compare the rate of hospitalization and mortality between RSV and influenza in this population. A systematic literature search until 15 June 2022 was done across several databases and including studies reporting incidence rate and cumulative incidence of hospitalization and mortality in RSV and influenza affecting older people. Among 2295 records initially screened, 16 studies including 762,084 older participants were included. Compared to older patients having influenza, patients with RSV did not show any significant different risk in hospitalization (either cumulative or incidence rate). Similar results were evident for mortality. The quality of the studies was in general good. In conclusion, our systematic review and meta-analysis showed that the rate of hospitalization and mortality was similar between RSV and influenza in older adults, suggesting the importance of vaccination for RSV in older people for preventing negative outcomes, such as mortality and hospitalization.https://www.mdpi.com/2076-393X/10/12/2092Respiratory Syncytial Virusinfluenzameta-analysishospitalizationmortality |
| spellingShingle | Stefania Maggi Nicola Veronese Marianna Burgio Giorgia Cammarata Maria Elena Ciuppa Stefano Ciriminna Francesco Di Gennaro Lee Smith Mike Trott Ligia J. Dominguez Giovanni M. Giammanco Simona De Grazia Claudio Costantino Francesco Vitale Mario Barbagallo Rate of Hospitalizations and Mortality of Respiratory Syncytial Virus Infection Compared to Influenza in Older People: A Systematic Review and Meta-Analysis Vaccines Respiratory Syncytial Virus influenza meta-analysis hospitalization mortality |
| title | Rate of Hospitalizations and Mortality of Respiratory Syncytial Virus Infection Compared to Influenza in Older People: A Systematic Review and Meta-Analysis |
| title_full | Rate of Hospitalizations and Mortality of Respiratory Syncytial Virus Infection Compared to Influenza in Older People: A Systematic Review and Meta-Analysis |
| title_fullStr | Rate of Hospitalizations and Mortality of Respiratory Syncytial Virus Infection Compared to Influenza in Older People: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Rate of Hospitalizations and Mortality of Respiratory Syncytial Virus Infection Compared to Influenza in Older People: A Systematic Review and Meta-Analysis |
| title_short | Rate of Hospitalizations and Mortality of Respiratory Syncytial Virus Infection Compared to Influenza in Older People: A Systematic Review and Meta-Analysis |
| title_sort | rate of hospitalizations and mortality of respiratory syncytial virus infection compared to influenza in older people a systematic review and meta analysis |
| topic | Respiratory Syncytial Virus influenza meta-analysis hospitalization mortality |
| url | https://www.mdpi.com/2076-393X/10/12/2092 |
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