Pulmonary Aspergillosis in Patients with Cystic Fibrosis in Russian Federation
The aim: to assess the incidence of various forms of pulmonary aspergillosis in patients with cystic fibrosis.Materials and methods. In 2014-2017 yy. in prospective study in different regions of Russia were included 190 patients with cystic fibrosis aged 1 to 37 years. Children – 130, adults – 60....
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Journal Infectology
2018-07-01
|
| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/726 |
| _version_ | 1797702141003956224 |
|---|---|
| author | Ya. I. Kozlova Yu. V. Borzova O. V. Shadrivova I. E. Suslova O. V. Aak S. M. Ignat’eva T. S. Bogomolova V. A. Ponnaja T. A. Stepanenko A. V. Orlov S. A. Krasovskiy N. N. Klimko |
| author_facet | Ya. I. Kozlova Yu. V. Borzova O. V. Shadrivova I. E. Suslova O. V. Aak S. M. Ignat’eva T. S. Bogomolova V. A. Ponnaja T. A. Stepanenko A. V. Orlov S. A. Krasovskiy N. N. Klimko |
| author_sort | Ya. I. Kozlova |
| collection | DOAJ |
| description | The aim: to assess the incidence of various forms of pulmonary aspergillosis in patients with cystic fibrosis.Materials and methods. In 2014-2017 yy. in prospective study in different regions of Russia were included 190 patients with cystic fibrosis aged 1 to 37 years. Children – 130, adults – 60. All patients underwent allergy (skin tests with fungal allergens, total IgE level, specific IgE to fungal allergens) and mycology (microscopy and cultural investigations of respiratory biomaterials) testing. Chest computed tomography was performed according to the indications.Results. The incidence of fungal sensitization in patients with cystic fibrosis was 57%, to Aspergillus spp. – 27%. The incidence of allergic bronchopulmonary aspergillosis was 5,7%, chronic lung aspergillosis – 4,2%, invasive aspergillosis developed in one patient (0,5%) during immunosuppressive therapy after liver transplantation.Conclusion. The incidence of pulmonary aspergillosis in patients with cystic fibrosis in the Russian Federation was first determined (10.5%). Mycology testing is indicated for patients with cystic fibrosis for early treatment of different variants of pulmonary aspergillosis. |
| first_indexed | 2024-03-12T04:46:50Z |
| format | Article |
| id | doaj.art-4c68e44e185d46ba9ec06ffc365ea592 |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2024-03-12T04:46:50Z |
| publishDate | 2018-07-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-4c68e44e185d46ba9ec06ffc365ea5922023-09-03T09:27:52ZrusJournal InfectologyЖурнал инфектологии2072-67322018-07-01102485410.22625/2072-6732-2018-10-2-48-54636Pulmonary Aspergillosis in Patients with Cystic Fibrosis in Russian FederationYa. I. Kozlova0Yu. V. Borzova1O. V. Shadrivova2I. E. Suslova3O. V. Aak4S. M. Ignat’eva5T. S. Bogomolova6V. A. Ponnaja7T. A. Stepanenko8A. V. Orlov9S. A. Krasovskiy10N. N. Klimko11Северо-Западный государственный медицинский университет имени И.И. МечниковаСеверо-Западный государственный медицинский университет имени И.И. МечниковаСеверо-Западный государственный медицинский университет имени И.И. МечниковаСеверо-Западный государственный медицинский университет имени И.И. МечниковаСеверо-Западный государственный медицинский университет имени И.И. МечниковаСеверо-Западный государственный медицинский университет имени И.И. МечниковаСеверо-Западный государственный медицинский университет имени И.И. МечниковаСеверо-Западный государственный медицинский университет имени И.И. МечниковаГородская многопрофильная больница № 2Северо-Западный государственный медицинский университет имени И.И. Мечникова Детская городская больница № 4 Святой ОльгиНаучно-исследовательский институт пульмонологииСеверо-Западный государственный медицинский университет имени И.И. МечниковаThe aim: to assess the incidence of various forms of pulmonary aspergillosis in patients with cystic fibrosis.Materials and methods. In 2014-2017 yy. in prospective study in different regions of Russia were included 190 patients with cystic fibrosis aged 1 to 37 years. Children – 130, adults – 60. All patients underwent allergy (skin tests with fungal allergens, total IgE level, specific IgE to fungal allergens) and mycology (microscopy and cultural investigations of respiratory biomaterials) testing. Chest computed tomography was performed according to the indications.Results. The incidence of fungal sensitization in patients with cystic fibrosis was 57%, to Aspergillus spp. – 27%. The incidence of allergic bronchopulmonary aspergillosis was 5,7%, chronic lung aspergillosis – 4,2%, invasive aspergillosis developed in one patient (0,5%) during immunosuppressive therapy after liver transplantation.Conclusion. The incidence of pulmonary aspergillosis in patients with cystic fibrosis in the Russian Federation was first determined (10.5%). Mycology testing is indicated for patients with cystic fibrosis for early treatment of different variants of pulmonary aspergillosis.https://journal.niidi.ru/jofin/article/view/726муковисцидозаспергиллезаллергический бронхолегочный аспергиллезaspergillus. |
| spellingShingle | Ya. I. Kozlova Yu. V. Borzova O. V. Shadrivova I. E. Suslova O. V. Aak S. M. Ignat’eva T. S. Bogomolova V. A. Ponnaja T. A. Stepanenko A. V. Orlov S. A. Krasovskiy N. N. Klimko Pulmonary Aspergillosis in Patients with Cystic Fibrosis in Russian Federation Журнал инфектологии муковисцидоз аспергиллез аллергический бронхолегочный аспергиллез aspergillus. |
| title | Pulmonary Aspergillosis in Patients with Cystic Fibrosis in Russian Federation |
| title_full | Pulmonary Aspergillosis in Patients with Cystic Fibrosis in Russian Federation |
| title_fullStr | Pulmonary Aspergillosis in Patients with Cystic Fibrosis in Russian Federation |
| title_full_unstemmed | Pulmonary Aspergillosis in Patients with Cystic Fibrosis in Russian Federation |
| title_short | Pulmonary Aspergillosis in Patients with Cystic Fibrosis in Russian Federation |
| title_sort | pulmonary aspergillosis in patients with cystic fibrosis in russian federation |
| topic | муковисцидоз аспергиллез аллергический бронхолегочный аспергиллез aspergillus. |
| url | https://journal.niidi.ru/jofin/article/view/726 |
| work_keys_str_mv | AT yaikozlova pulmonaryaspergillosisinpatientswithcysticfibrosisinrussianfederation AT yuvborzova pulmonaryaspergillosisinpatientswithcysticfibrosisinrussianfederation AT ovshadrivova pulmonaryaspergillosisinpatientswithcysticfibrosisinrussianfederation AT iesuslova pulmonaryaspergillosisinpatientswithcysticfibrosisinrussianfederation AT ovaak pulmonaryaspergillosisinpatientswithcysticfibrosisinrussianfederation AT smignateva pulmonaryaspergillosisinpatientswithcysticfibrosisinrussianfederation AT tsbogomolova pulmonaryaspergillosisinpatientswithcysticfibrosisinrussianfederation AT vaponnaja pulmonaryaspergillosisinpatientswithcysticfibrosisinrussianfederation AT tastepanenko pulmonaryaspergillosisinpatientswithcysticfibrosisinrussianfederation AT avorlov pulmonaryaspergillosisinpatientswithcysticfibrosisinrussianfederation AT sakrasovskiy pulmonaryaspergillosisinpatientswithcysticfibrosisinrussianfederation AT nnklimko pulmonaryaspergillosisinpatientswithcysticfibrosisinrussianfederation |