Novel Isolation Method Reveals Sex-Specific Composition and Neurotoxicity of Small Extracellular Vesicles in a Mouse Model of Alzheimer’s Disease

Novel Isolation Method Reveals Sex-Specific Composition and Neurotoxicity of Small Extracellular Vesicles in a Mouse Model of Alzheimer’s Disease

We developed a new method to isolate small extracellular vesicles (sEVs) from male and female wild-type and 5xFAD mouse brains to investigate the sex-specific functions of sEVs in Alzheimer’s disease (AD). A mass spectrometric analysis revealed that sEVs contained proteins critical for EV formation...

ver descrição completa

Detalhes bibliográficos
Principais autores: Ahmed Elsherbini, Zhihui Zhu, Zainuddin Quadri, Simone M. Crivelli, Xiaojia Ren, Hemendra J. Vekaria, Priyanka Tripathi, Liping Zhang, Wenbo Zhi, Erhard Bieberich
Formato: Artigo
Idioma:English
Publicado em: MDPI AG 2023-06-01
coleção:Cells
Assuntos:
extracellular vesicles
Alzheimer’s
acid sphingomyelinase
ceramide
neurotoxicity
Acesso em linha:https://www.mdpi.com/2073-4409/12/12/1623

Internet

https://www.mdpi.com/2073-4409/12/12/1623

Registros relacionados