Discovery of a New Chalcone-Trimethoxycinnamide Hybrid with Antimitotic Effect: Design, Synthesis, and Structure—Activity Relationship Studies

Discovery of a New Chalcone-Trimethoxycinnamide Hybrid with Antimitotic Effect: Design, Synthesis, and Structure—Activity Relationship Studies

In this work, the design and synthesis of a new chalcone-trimethoxycinnamide hybrid (<b>7</b>) based on the combination of subunits of two promising antiproliferative compounds (<b>CM-M345</b> (<b>1</b>) and <b>BP-M345</b> (<b>2</b>)), prev...

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Bibliographic Details
Main Authors: Joana Moreira, Patrícia M. A. Silva, Matilde Barros, Lucília Saraiva, Madalena Pinto, Hassan Bousbaa, Honorina Cidade
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Pharmaceuticals
Subjects:
chalcones
diarylpentanoids
hybrids
antitumor activity
apoptosis
p53
Online Access:https://www.mdpi.com/1424-8247/16/6/879

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