Phytochemical Analysis and In Vitro Cytotoxic Activity against Colorectal Adenocarcinoma Cells of <i>Hippophae rhamnodies</i> L., <i>Cymbopogon citratus</i> (D.C.) Stapf, and <i>Ocimum basilicum</i> L. Essential Oils
Colorectal carcinoma (CRC) is one of the most frequently diagnosed cancer types with current deficient and aggressive treatment options, but various studied alternative therapies are able to efficiently contribute to its management. Essential oils (EOs) contain valuable compounds, with antibacterial...
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2021-12-01
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author | Alina Dolghi Roxana Buzatu Amadeus Dobrescu Flavius Olaru Grigore Alexandru Popescu Iasmina Marcovici Iulia Pinzaru Dan Navolan Octavian Marius Cretu Iuliana Popescu Cristina Adriana Dehelean |
author_facet | Alina Dolghi Roxana Buzatu Amadeus Dobrescu Flavius Olaru Grigore Alexandru Popescu Iasmina Marcovici Iulia Pinzaru Dan Navolan Octavian Marius Cretu Iuliana Popescu Cristina Adriana Dehelean |
author_sort | Alina Dolghi |
collection | DOAJ |
description | Colorectal carcinoma (CRC) is one of the most frequently diagnosed cancer types with current deficient and aggressive treatment options, but various studied alternative therapies are able to efficiently contribute to its management. Essential oils (EOs) contain valuable compounds, with antibacterial, anti-inflammatory, and anticancer properties, which might serve as effective solutions in CRC prophylaxis or treatment. The aim of the present work was to evaluate the phytochemical composition and in vitro biological activity of essential oils derived from <i>Hippophae rhamnoides</i> (Hr_EO), <i>Cymbopogon citratus</i> (Cc_EO), and <i>Ocimum basilicum</i> (Ob_EO) species on HT-29 and Caco-2 human colorectal adenocarcinoma cell lines. The main compounds identified by GC-MS analysis were estragole (Hr_EO, Ob_EO), alpha- and beta-citral (Cc_EO). All tested EOs exerted a dose-dependent cytotoxicity on both cell lines by reducing the cell viability, especially in the case of Cc_EO, where at 75 µg/mL the viability percentages reached the values of 62.69% (Caco-2) and 64.09% (HT-29), respectively. The nuclear morphology evaluation highlighted significant dysmorphologies on both lines after their treatment with EOs at 75 µg/mL. |
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spelling | doaj.art-4c6fdb920f814ed2a0435aaff158f5c22023-11-23T10:12:39ZengMDPI AGPlants2223-77472021-12-011012275210.3390/plants10122752Phytochemical Analysis and In Vitro Cytotoxic Activity against Colorectal Adenocarcinoma Cells of <i>Hippophae rhamnodies</i> L., <i>Cymbopogon citratus</i> (D.C.) Stapf, and <i>Ocimum basilicum</i> L. Essential OilsAlina Dolghi0Roxana Buzatu1Amadeus Dobrescu2Flavius Olaru3Grigore Alexandru Popescu4Iasmina Marcovici5Iulia Pinzaru6Dan Navolan7Octavian Marius Cretu8Iuliana Popescu9Cristina Adriana Dehelean10Department of Toxicology and Drug Industry, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. No. 2, 300041 Timisoara, RomaniaDepartment of Dental Aesthetics, Faculty of Dental Medicine, “Victor Babeș” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. No. 2, 300041 Timișoara, RomaniaDepartment of Surgery, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. No. 2, 300041 Timisoara, RomaniaDepartment of Obstetrics-Gynecology, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. No. 2, 300041 Timisoara, RomaniaDepartment of Surgery, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. No. 2, 300041 Timisoara, RomaniaDepartment of Toxicology and Drug Industry, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. No. 2, 300041 Timisoara, RomaniaDepartment of Toxicology and Drug Industry, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. No. 2, 300041 Timisoara, RomaniaDepartment of Obstetrics-Gynecology, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. No. 2, 300041 Timisoara, RomaniaDepartment of Surgery, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. No. 2, 300041 Timisoara, RomaniaDepartment of Soil Sciences, Faculty of Agriculture, Banat University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania”, Calea Aradului 119, 300645 Timişoara, RomaniaDepartment of Toxicology and Drug Industry, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. No. 2, 300041 Timisoara, RomaniaColorectal carcinoma (CRC) is one of the most frequently diagnosed cancer types with current deficient and aggressive treatment options, but various studied alternative therapies are able to efficiently contribute to its management. Essential oils (EOs) contain valuable compounds, with antibacterial, anti-inflammatory, and anticancer properties, which might serve as effective solutions in CRC prophylaxis or treatment. The aim of the present work was to evaluate the phytochemical composition and in vitro biological activity of essential oils derived from <i>Hippophae rhamnoides</i> (Hr_EO), <i>Cymbopogon citratus</i> (Cc_EO), and <i>Ocimum basilicum</i> (Ob_EO) species on HT-29 and Caco-2 human colorectal adenocarcinoma cell lines. The main compounds identified by GC-MS analysis were estragole (Hr_EO, Ob_EO), alpha- and beta-citral (Cc_EO). All tested EOs exerted a dose-dependent cytotoxicity on both cell lines by reducing the cell viability, especially in the case of Cc_EO, where at 75 µg/mL the viability percentages reached the values of 62.69% (Caco-2) and 64.09% (HT-29), respectively. The nuclear morphology evaluation highlighted significant dysmorphologies on both lines after their treatment with EOs at 75 µg/mL.https://www.mdpi.com/2223-7747/10/12/2752essential oilstumor cellsviabilitynuclear morphologymigratory capacity |
spellingShingle | Alina Dolghi Roxana Buzatu Amadeus Dobrescu Flavius Olaru Grigore Alexandru Popescu Iasmina Marcovici Iulia Pinzaru Dan Navolan Octavian Marius Cretu Iuliana Popescu Cristina Adriana Dehelean Phytochemical Analysis and In Vitro Cytotoxic Activity against Colorectal Adenocarcinoma Cells of <i>Hippophae rhamnodies</i> L., <i>Cymbopogon citratus</i> (D.C.) Stapf, and <i>Ocimum basilicum</i> L. Essential Oils Plants essential oils tumor cells viability nuclear morphology migratory capacity |
title | Phytochemical Analysis and In Vitro Cytotoxic Activity against Colorectal Adenocarcinoma Cells of <i>Hippophae rhamnodies</i> L., <i>Cymbopogon citratus</i> (D.C.) Stapf, and <i>Ocimum basilicum</i> L. Essential Oils |
title_full | Phytochemical Analysis and In Vitro Cytotoxic Activity against Colorectal Adenocarcinoma Cells of <i>Hippophae rhamnodies</i> L., <i>Cymbopogon citratus</i> (D.C.) Stapf, and <i>Ocimum basilicum</i> L. Essential Oils |
title_fullStr | Phytochemical Analysis and In Vitro Cytotoxic Activity against Colorectal Adenocarcinoma Cells of <i>Hippophae rhamnodies</i> L., <i>Cymbopogon citratus</i> (D.C.) Stapf, and <i>Ocimum basilicum</i> L. Essential Oils |
title_full_unstemmed | Phytochemical Analysis and In Vitro Cytotoxic Activity against Colorectal Adenocarcinoma Cells of <i>Hippophae rhamnodies</i> L., <i>Cymbopogon citratus</i> (D.C.) Stapf, and <i>Ocimum basilicum</i> L. Essential Oils |
title_short | Phytochemical Analysis and In Vitro Cytotoxic Activity against Colorectal Adenocarcinoma Cells of <i>Hippophae rhamnodies</i> L., <i>Cymbopogon citratus</i> (D.C.) Stapf, and <i>Ocimum basilicum</i> L. Essential Oils |
title_sort | phytochemical analysis and in vitro cytotoxic activity against colorectal adenocarcinoma cells of i hippophae rhamnodies i l i cymbopogon citratus i d c stapf and i ocimum basilicum i l essential oils |
topic | essential oils tumor cells viability nuclear morphology migratory capacity |
url | https://www.mdpi.com/2223-7747/10/12/2752 |
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