Feasibility of 15O-water PET studies of auditory system activation during general anesthesia in children
Abstract Background 15O-Water positron emission tomography (PET) enables functional imaging of the auditory system during stimulation via a promontory electrode or cochlear implant, which is not possible using functional magnetic resonance imaging (fMRI). Although PET has been introduced in this con...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-02-01
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| Series: | EJNMMI Research |
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| Online Access: | http://link.springer.com/article/10.1186/s13550-018-0362-z |
| _version_ | 1819083985726210048 |
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| author | Martin Mamach Florian Wilke Martin Durisin Frank A. Beger Mareike Finke Andreas Büchner Barbara Schultz Arthur Schultz Lilli Geworski Frank M. Bengel Thomas Lenarz Anke Lesinski-Schiedat Georg Berding |
| author_facet | Martin Mamach Florian Wilke Martin Durisin Frank A. Beger Mareike Finke Andreas Büchner Barbara Schultz Arthur Schultz Lilli Geworski Frank M. Bengel Thomas Lenarz Anke Lesinski-Schiedat Georg Berding |
| author_sort | Martin Mamach |
| collection | DOAJ |
| description | Abstract Background 15O-Water positron emission tomography (PET) enables functional imaging of the auditory system during stimulation via a promontory electrode or cochlear implant, which is not possible using functional magnetic resonance imaging (fMRI). Although PET has been introduced in this context decades ago, its feasibility when performed during general anesthesia has not yet been explored. However, due to a shift to earlier (and bilateral) auditory implantation, the need to study children during general anesthesia appeared, since they are not able to cooperate during scanning. Therefore, we evaluated retrospectively results of individual SPM (statistical parametric mapping) analysis of 15O-water PET in 17 children studied during general anesthesia and compared them to those in 9 adults studied while awake. Specifically, the influence of scan duration, smoothing filter kernel employed during preprocessing, and cut-off value used for statistical inferences were evaluated. Frequencies, peak heights, and extents of activations in auditory and extra-auditory brain regions (AR and eAR) were registered. Results It was possible to demonstrate activations in auditory brain regions during general anesthesia; however, the frequency and markedness of positive findings were dependent on some of the abovementioned influence factors. Scan duration (60 vs. 90 s) had no significant influence on peak height of auditory cortex activations. To achieve a similar frequency and extent of AR activations during general anesthesia compared to waking state, a lower cut-off for statistical inferences (p < 0.05 or p < 0.01 vs. p < 0.001) had to be applied. However, this lower cut-off was frequently associated with unexpected, “artificial” activations in eAR. These activations in eAR could be slightly reduced by the use of a stronger smoothing filter kernel during preprocessing of the data (e.g., [30 mm]3). Conclusions Our data indicate that it is feasible to detect auditory cortex activations in 15O-water PET during general anesthesia. Combined with the improved signal to noise ratios of modern PET scanners, this suggests reasonable prospects for further evaluation of the method for clinical use in auditory implant users. Adapted parameters for data analysis seem to be helpful to improve the proportion of signals in AR versus eAR. |
| first_indexed | 2024-12-21T20:41:16Z |
| format | Article |
| id | doaj.art-4c704213cfc748fd89952e79c75c1faa |
| institution | Directory Open Access Journal |
| issn | 2191-219X |
| language | English |
| last_indexed | 2024-12-21T20:41:16Z |
| publishDate | 2018-02-01 |
| publisher | SpringerOpen |
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| series | EJNMMI Research |
| spelling | doaj.art-4c704213cfc748fd89952e79c75c1faa2022-12-21T18:50:57ZengSpringerOpenEJNMMI Research2191-219X2018-02-018111210.1186/s13550-018-0362-zFeasibility of 15O-water PET studies of auditory system activation during general anesthesia in childrenMartin Mamach0Florian Wilke1Martin Durisin2Frank A. Beger3Mareike Finke4Andreas Büchner5Barbara Schultz6Arthur Schultz7Lilli Geworski8Frank M. Bengel9Thomas Lenarz10Anke Lesinski-Schiedat11Georg Berding12Department of Nuclear Medicine, Hannover Medical SchoolDepartment of Medical Physics and Radiation Protection, Hannover Medical SchoolDepartment of Otolaryngology, Hannover Medical SchoolDepartment of Anesthesiology and Intensive Care Medicine, Hospital Diakovere AnnastiftCluster of Excellence Hearing4all, Hannover Medical SchoolCluster of Excellence Hearing4all, Hannover Medical SchoolDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical SchoolDepartment of Anesthesiology and Intensive Care Medicine, Hannover Medical SchoolDepartment of Medical Physics and Radiation Protection, Hannover Medical SchoolDepartment of Nuclear Medicine, Hannover Medical SchoolCluster of Excellence Hearing4all, Hannover Medical SchoolDepartment of Otolaryngology, Hannover Medical SchoolDepartment of Nuclear Medicine, Hannover Medical SchoolAbstract Background 15O-Water positron emission tomography (PET) enables functional imaging of the auditory system during stimulation via a promontory electrode or cochlear implant, which is not possible using functional magnetic resonance imaging (fMRI). Although PET has been introduced in this context decades ago, its feasibility when performed during general anesthesia has not yet been explored. However, due to a shift to earlier (and bilateral) auditory implantation, the need to study children during general anesthesia appeared, since they are not able to cooperate during scanning. Therefore, we evaluated retrospectively results of individual SPM (statistical parametric mapping) analysis of 15O-water PET in 17 children studied during general anesthesia and compared them to those in 9 adults studied while awake. Specifically, the influence of scan duration, smoothing filter kernel employed during preprocessing, and cut-off value used for statistical inferences were evaluated. Frequencies, peak heights, and extents of activations in auditory and extra-auditory brain regions (AR and eAR) were registered. Results It was possible to demonstrate activations in auditory brain regions during general anesthesia; however, the frequency and markedness of positive findings were dependent on some of the abovementioned influence factors. Scan duration (60 vs. 90 s) had no significant influence on peak height of auditory cortex activations. To achieve a similar frequency and extent of AR activations during general anesthesia compared to waking state, a lower cut-off for statistical inferences (p < 0.05 or p < 0.01 vs. p < 0.001) had to be applied. However, this lower cut-off was frequently associated with unexpected, “artificial” activations in eAR. These activations in eAR could be slightly reduced by the use of a stronger smoothing filter kernel during preprocessing of the data (e.g., [30 mm]3). Conclusions Our data indicate that it is feasible to detect auditory cortex activations in 15O-water PET during general anesthesia. Combined with the improved signal to noise ratios of modern PET scanners, this suggests reasonable prospects for further evaluation of the method for clinical use in auditory implant users. Adapted parameters for data analysis seem to be helpful to improve the proportion of signals in AR versus eAR.http://link.springer.com/article/10.1186/s13550-018-0362-z15O-water PETScan durationSmoothing filter kernelCut-off for statistical inferencesCochlear implantPromontory needle electrode |
| spellingShingle | Martin Mamach Florian Wilke Martin Durisin Frank A. Beger Mareike Finke Andreas Büchner Barbara Schultz Arthur Schultz Lilli Geworski Frank M. Bengel Thomas Lenarz Anke Lesinski-Schiedat Georg Berding Feasibility of 15O-water PET studies of auditory system activation during general anesthesia in children EJNMMI Research 15O-water PET Scan duration Smoothing filter kernel Cut-off for statistical inferences Cochlear implant Promontory needle electrode |
| title | Feasibility of 15O-water PET studies of auditory system activation during general anesthesia in children |
| title_full | Feasibility of 15O-water PET studies of auditory system activation during general anesthesia in children |
| title_fullStr | Feasibility of 15O-water PET studies of auditory system activation during general anesthesia in children |
| title_full_unstemmed | Feasibility of 15O-water PET studies of auditory system activation during general anesthesia in children |
| title_short | Feasibility of 15O-water PET studies of auditory system activation during general anesthesia in children |
| title_sort | feasibility of 15o water pet studies of auditory system activation during general anesthesia in children |
| topic | 15O-water PET Scan duration Smoothing filter kernel Cut-off for statistical inferences Cochlear implant Promontory needle electrode |
| url | http://link.springer.com/article/10.1186/s13550-018-0362-z |
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