Effect of acute adrenalectomy on rat liver glucocorticoid receptor
In order to improve current clinical treatment of human hypocortisolism, it is necessary to understand molecular aspects of this pathophysiology. In this study liver tissues from male Wistar rats were used as an experimental model to study structural and functional properties of glucocorticoid recep...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2006-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2006/0354-46640603153I.pdf |
| _version_ | 1819043490239086592 |
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| author | Isenović Esma R. Radojčić Marija Žakula Zorica Korićanac Goran Ribarac-Stepić Nevena |
| author_facet | Isenović Esma R. Radojčić Marija Žakula Zorica Korićanac Goran Ribarac-Stepić Nevena |
| author_sort | Isenović Esma R. |
| collection | DOAJ |
| description | In order to improve current clinical treatment of human hypocortisolism, it is necessary to understand molecular aspects of this pathophysiology. In this study liver tissues from male Wistar rats were used as an experimental model to study structural and functional properties of glucocorticoid receptor (GR) in the absence of glucocorticoid hormones (GC). Results show that acute adrenalectomy (ADX) significantly increases the number of GR binding sites and GR protein content. In addition, acute ADX stimulates increase in stability of the GR, decrease in stability of the glucocorticoid- receptor complex (G-R), and changes in accumulation of the G-R complex in nuclei and its cellular distribution. . |
| first_indexed | 2024-12-21T09:57:37Z |
| format | Article |
| id | doaj.art-4c7089b7a65f4441888f08056a1ed873 |
| institution | Directory Open Access Journal |
| issn | 0354-4664 |
| language | English |
| last_indexed | 2024-12-21T09:57:37Z |
| publishDate | 2006-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-4c7089b7a65f4441888f08056a1ed8732022-12-21T19:08:01ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46642006-01-0158315315910.2298/ABS0603153IEffect of acute adrenalectomy on rat liver glucocorticoid receptorIsenović Esma R.Radojčić MarijaŽakula ZoricaKorićanac GoranRibarac-Stepić NevenaIn order to improve current clinical treatment of human hypocortisolism, it is necessary to understand molecular aspects of this pathophysiology. In this study liver tissues from male Wistar rats were used as an experimental model to study structural and functional properties of glucocorticoid receptor (GR) in the absence of glucocorticoid hormones (GC). Results show that acute adrenalectomy (ADX) significantly increases the number of GR binding sites and GR protein content. In addition, acute ADX stimulates increase in stability of the GR, decrease in stability of the glucocorticoid- receptor complex (G-R), and changes in accumulation of the G-R complex in nuclei and its cellular distribution. .http://www.doiserbia.nb.rs/img/doi/0354-4664/2006/0354-46640603153I.pdfadrenalectomyglucocorticoid receptornumber of binding sitesreceptor protein contentstability of glucocorticoid-receptor complexnuclear translocation |
| spellingShingle | Isenović Esma R. Radojčić Marija Žakula Zorica Korićanac Goran Ribarac-Stepić Nevena Effect of acute adrenalectomy on rat liver glucocorticoid receptor Archives of Biological Sciences adrenalectomy glucocorticoid receptor number of binding sites receptor protein content stability of glucocorticoid-receptor complex nuclear translocation |
| title | Effect of acute adrenalectomy on rat liver glucocorticoid receptor |
| title_full | Effect of acute adrenalectomy on rat liver glucocorticoid receptor |
| title_fullStr | Effect of acute adrenalectomy on rat liver glucocorticoid receptor |
| title_full_unstemmed | Effect of acute adrenalectomy on rat liver glucocorticoid receptor |
| title_short | Effect of acute adrenalectomy on rat liver glucocorticoid receptor |
| title_sort | effect of acute adrenalectomy on rat liver glucocorticoid receptor |
| topic | adrenalectomy glucocorticoid receptor number of binding sites receptor protein content stability of glucocorticoid-receptor complex nuclear translocation |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2006/0354-46640603153I.pdf |
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