The impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites
Abstract This study aims to explore the immediate effects of bariatric surgery on serum tryptophan–kynurenine pathway metabolites in individuals with type 2 diabetes and BMI > 30. With the goal of providing insight into the link between tryptophan pathway metabolites, type 2 diabetes, and chronic...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-01-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-03833-4 |
| _version_ | 1818750242806300672 |
|---|---|
| author | Kai Tai Derek Yeung Nicholas Penney Luke Whiley Hutan Ashrafian Matthew R. Lewis Sanjay Purkayastha Ara Darzi Elaine Holmes |
| author_facet | Kai Tai Derek Yeung Nicholas Penney Luke Whiley Hutan Ashrafian Matthew R. Lewis Sanjay Purkayastha Ara Darzi Elaine Holmes |
| author_sort | Kai Tai Derek Yeung |
| collection | DOAJ |
| description | Abstract This study aims to explore the immediate effects of bariatric surgery on serum tryptophan–kynurenine pathway metabolites in individuals with type 2 diabetes and BMI > 30. With the goal of providing insight into the link between tryptophan pathway metabolites, type 2 diabetes, and chronic obesity-induced inflammation. This longitudinal study included 20 participants. Half were diagnosed with type 2 diabetes. 11 and 9 underwent RYGB and SG respectively. Blood samples were obtained at pre-operative and 3 months post-operative timepoints. Tryptophan and downstream metabolites of the kynurenine pathway were quantified with an ultrahigh-performance liquid chromatography tandem mass spectrometry with electrospray ionisation method. At 3 months post-operation, RYGB led to significant reductions in tryptophan, kynurenic acid and xanthurenic acid levels when compared to baseline. Significant reductions of the same metabolites after surgery were also observed in individuals with T2D irrespective of surgical procedure. These metabolites were significantly correlated with serum HbA1c levels and BMI. Bariatric surgery, in particular RYGB reduces serum levels of tryptophan and its downstream kynurenine metabolites. These metabolites are associated with T2D and thought to be potentially mechanistic in the systemic processes of obesity induced inflammation leading to insulin resistance. Its reduction after surgery is associated with an improvement in glycaemic control (HbA1c). |
| first_indexed | 2024-12-18T04:16:34Z |
| format | Article |
| id | doaj.art-4c7247d8355e42258d43779e7d2ec03d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T04:16:34Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4c7247d8355e42258d43779e7d2ec03d2022-12-21T21:21:19ZengNature PortfolioScientific Reports2045-23222022-01-0112111210.1038/s41598-021-03833-4The impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolitesKai Tai Derek Yeung0Nicholas Penney1Luke Whiley2Hutan Ashrafian3Matthew R. Lewis4Sanjay Purkayastha5Ara Darzi6Elaine Holmes7Department of Surgery & Cancer, Imperial College LondonDepartment of Surgery & Cancer, Imperial College LondonDepartment of Surgery & Cancer, Imperial College LondonDepartment of Surgery & Cancer, Imperial College LondonNational Phenome Centre, Imperial College LondonDepartment of Surgery & Cancer, Imperial College LondonDepartment of Surgery & Cancer, Imperial College LondonDepartment of Surgery & Cancer, Imperial College LondonAbstract This study aims to explore the immediate effects of bariatric surgery on serum tryptophan–kynurenine pathway metabolites in individuals with type 2 diabetes and BMI > 30. With the goal of providing insight into the link between tryptophan pathway metabolites, type 2 diabetes, and chronic obesity-induced inflammation. This longitudinal study included 20 participants. Half were diagnosed with type 2 diabetes. 11 and 9 underwent RYGB and SG respectively. Blood samples were obtained at pre-operative and 3 months post-operative timepoints. Tryptophan and downstream metabolites of the kynurenine pathway were quantified with an ultrahigh-performance liquid chromatography tandem mass spectrometry with electrospray ionisation method. At 3 months post-operation, RYGB led to significant reductions in tryptophan, kynurenic acid and xanthurenic acid levels when compared to baseline. Significant reductions of the same metabolites after surgery were also observed in individuals with T2D irrespective of surgical procedure. These metabolites were significantly correlated with serum HbA1c levels and BMI. Bariatric surgery, in particular RYGB reduces serum levels of tryptophan and its downstream kynurenine metabolites. These metabolites are associated with T2D and thought to be potentially mechanistic in the systemic processes of obesity induced inflammation leading to insulin resistance. Its reduction after surgery is associated with an improvement in glycaemic control (HbA1c).https://doi.org/10.1038/s41598-021-03833-4 |
| spellingShingle | Kai Tai Derek Yeung Nicholas Penney Luke Whiley Hutan Ashrafian Matthew R. Lewis Sanjay Purkayastha Ara Darzi Elaine Holmes The impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites Scientific Reports |
| title | The impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites |
| title_full | The impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites |
| title_fullStr | The impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites |
| title_full_unstemmed | The impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites |
| title_short | The impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites |
| title_sort | impact of bariatric surgery on serum tryptophan kynurenine pathway metabolites |
| url | https://doi.org/10.1038/s41598-021-03833-4 |
| work_keys_str_mv | AT kaitaiderekyeung theimpactofbariatricsurgeryonserumtryptophankynureninepathwaymetabolites AT nicholaspenney theimpactofbariatricsurgeryonserumtryptophankynureninepathwaymetabolites AT lukewhiley theimpactofbariatricsurgeryonserumtryptophankynureninepathwaymetabolites AT hutanashrafian theimpactofbariatricsurgeryonserumtryptophankynureninepathwaymetabolites AT matthewrlewis theimpactofbariatricsurgeryonserumtryptophankynureninepathwaymetabolites AT sanjaypurkayastha theimpactofbariatricsurgeryonserumtryptophankynureninepathwaymetabolites AT aradarzi theimpactofbariatricsurgeryonserumtryptophankynureninepathwaymetabolites AT elaineholmes theimpactofbariatricsurgeryonserumtryptophankynureninepathwaymetabolites AT kaitaiderekyeung impactofbariatricsurgeryonserumtryptophankynureninepathwaymetabolites AT nicholaspenney impactofbariatricsurgeryonserumtryptophankynureninepathwaymetabolites AT lukewhiley impactofbariatricsurgeryonserumtryptophankynureninepathwaymetabolites AT hutanashrafian impactofbariatricsurgeryonserumtryptophankynureninepathwaymetabolites AT matthewrlewis impactofbariatricsurgeryonserumtryptophankynureninepathwaymetabolites AT sanjaypurkayastha impactofbariatricsurgeryonserumtryptophankynureninepathwaymetabolites AT aradarzi impactofbariatricsurgeryonserumtryptophankynureninepathwaymetabolites AT elaineholmes impactofbariatricsurgeryonserumtryptophankynureninepathwaymetabolites |