Intracranial tumors of the central nervous system and air pollution – a nationwide case-control study from Denmark
Abstract Background Inconclusive evidence has suggested a possible link between air pollution and central nervous system (CNS) tumors. We investigated a range of air pollutants in relation to types of CNS tumors. Methods We identified all (n = 21,057) intracranial tumors in brain, meninges and crani...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | Environmental Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12940-020-00631-9 |
| _version_ | 1818963065655263232 |
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| author | Aslak Harbo Poulsen Ulla Arthur Hvidtfeldt Mette Sørensen Robin Puett Matthias Ketzel Jørgen Brandt Camilla Geels Jesper H. Christensen Ole Raaschou-Nielsen |
| author_facet | Aslak Harbo Poulsen Ulla Arthur Hvidtfeldt Mette Sørensen Robin Puett Matthias Ketzel Jørgen Brandt Camilla Geels Jesper H. Christensen Ole Raaschou-Nielsen |
| author_sort | Aslak Harbo Poulsen |
| collection | DOAJ |
| description | Abstract Background Inconclusive evidence has suggested a possible link between air pollution and central nervous system (CNS) tumors. We investigated a range of air pollutants in relation to types of CNS tumors. Methods We identified all (n = 21,057) intracranial tumors in brain, meninges and cranial nerves diagnosed in Denmark between 1989 and 2014 and matched controls on age, sex and year of birth. We established personal 10-year mean residential outdoor exposure to particulate matter < 2.5 μm (PM2.5), nitrous oxides (NOX), primary emitted black carbon (BC) and ozone. We used conditional logistic regression to calculate odds ratios (OR) linearly (per interquartile range (IQR)) and categorically. We accounted for personal income, employment, marital status, use of medication as well as socio-demographic conditions at area level. Results Malignant tumors of the intracranial CNS was associated with BC (OR: 1.034, 95%CI: 1.005–1.065 per IQR. For NOx the OR per IQR was 1.026 (95%CI: 0.998–1.056). For malignant non-glioma tumors of the brain we found associations with PM2.5 (OR: 1.267, 95%CI: 1.053–1.524 per IQR), BC (OR: 1.049, 95%CI: 0.996–1.106) and NOx (OR: 1.051, 95% CI: 0.996–1.110). Conclusion Our results suggest that air pollution is associated with malignant intracranial CNS tumors and malignant non-glioma of the brain. However, additional studies are needed. |
| first_indexed | 2024-12-20T12:39:18Z |
| format | Article |
| id | doaj.art-4c73a96bc07b4f498eac55a8616b0923 |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-12-20T12:39:18Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-4c73a96bc07b4f498eac55a8616b09232022-12-21T19:40:32ZengBMCEnvironmental Health1476-069X2020-07-0119111210.1186/s12940-020-00631-9Intracranial tumors of the central nervous system and air pollution – a nationwide case-control study from DenmarkAslak Harbo Poulsen0Ulla Arthur Hvidtfeldt1Mette Sørensen2Robin Puett3Matthias Ketzel4Jørgen Brandt5Camilla Geels6Jesper H. Christensen7Ole Raaschou-Nielsen8Danish Cancer Society Research CenterDanish Cancer Society Research CenterDanish Cancer Society Research CenterDanish Cancer Society Research CenterDepartment of Environmental Science, Aarhus UniversityDepartment of Environmental Science, Aarhus UniversityDepartment of Environmental Science, Aarhus UniversityDepartment of Environmental Science, Aarhus UniversityDanish Cancer Society Research CenterAbstract Background Inconclusive evidence has suggested a possible link between air pollution and central nervous system (CNS) tumors. We investigated a range of air pollutants in relation to types of CNS tumors. Methods We identified all (n = 21,057) intracranial tumors in brain, meninges and cranial nerves diagnosed in Denmark between 1989 and 2014 and matched controls on age, sex and year of birth. We established personal 10-year mean residential outdoor exposure to particulate matter < 2.5 μm (PM2.5), nitrous oxides (NOX), primary emitted black carbon (BC) and ozone. We used conditional logistic regression to calculate odds ratios (OR) linearly (per interquartile range (IQR)) and categorically. We accounted for personal income, employment, marital status, use of medication as well as socio-demographic conditions at area level. Results Malignant tumors of the intracranial CNS was associated with BC (OR: 1.034, 95%CI: 1.005–1.065 per IQR. For NOx the OR per IQR was 1.026 (95%CI: 0.998–1.056). For malignant non-glioma tumors of the brain we found associations with PM2.5 (OR: 1.267, 95%CI: 1.053–1.524 per IQR), BC (OR: 1.049, 95%CI: 0.996–1.106) and NOx (OR: 1.051, 95% CI: 0.996–1.110). Conclusion Our results suggest that air pollution is associated with malignant intracranial CNS tumors and malignant non-glioma of the brain. However, additional studies are needed.http://link.springer.com/article/10.1186/s12940-020-00631-9EpidemiologyAir pollutionRegister studyCNS-tumors |
| spellingShingle | Aslak Harbo Poulsen Ulla Arthur Hvidtfeldt Mette Sørensen Robin Puett Matthias Ketzel Jørgen Brandt Camilla Geels Jesper H. Christensen Ole Raaschou-Nielsen Intracranial tumors of the central nervous system and air pollution – a nationwide case-control study from Denmark Environmental Health Epidemiology Air pollution Register study CNS-tumors |
| title | Intracranial tumors of the central nervous system and air pollution – a nationwide case-control study from Denmark |
| title_full | Intracranial tumors of the central nervous system and air pollution – a nationwide case-control study from Denmark |
| title_fullStr | Intracranial tumors of the central nervous system and air pollution – a nationwide case-control study from Denmark |
| title_full_unstemmed | Intracranial tumors of the central nervous system and air pollution – a nationwide case-control study from Denmark |
| title_short | Intracranial tumors of the central nervous system and air pollution – a nationwide case-control study from Denmark |
| title_sort | intracranial tumors of the central nervous system and air pollution a nationwide case control study from denmark |
| topic | Epidemiology Air pollution Register study CNS-tumors |
| url | http://link.springer.com/article/10.1186/s12940-020-00631-9 |
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