Low skeletal muscle radiodensity is the best predictor for short-term major surgical complications in gastrointestinal surgical cancer: A cohort study.
The aim of this study was to evaluate whether body composition, muscle function, and their association are predictive factors for short-term postoperative complications in patients with gastric and colorectal cancer. A prospective cohort study was conducted with patients undergoing resection of gast...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0247322 |
| _version_ | 1818743027826425856 |
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| author | Ana Lúcia Miranda de Carvalho Maria Cristina Gonzalez Iasmin Matias de Sousa Isabel Pinto Amorim das Virgens Galtieri Otavio Cunha de Medeiros Marília Nelo Oliveira Jeane Cristina Alves de Souza Dantas Ana Paula Trussardi Fayh |
| author_facet | Ana Lúcia Miranda de Carvalho Maria Cristina Gonzalez Iasmin Matias de Sousa Isabel Pinto Amorim das Virgens Galtieri Otavio Cunha de Medeiros Marília Nelo Oliveira Jeane Cristina Alves de Souza Dantas Ana Paula Trussardi Fayh |
| author_sort | Ana Lúcia Miranda de Carvalho |
| collection | DOAJ |
| description | The aim of this study was to evaluate whether body composition, muscle function, and their association are predictive factors for short-term postoperative complications in patients with gastric and colorectal cancer. A prospective cohort study was conducted with patients undergoing resection of gastric and colorectal tumors. Nutritional status was assessed using Patient-Generated Subjective Global Assessment (PG-SGA) and anthropometric techniques. Low handgrip strength (HGS) was observed when <16kg for women, and <27kg for men. Computed tomography images were used to measure visceral adipose tissue, skeletal muscle index (SMI), and skeletal muscle radiodensity (SMD). Complications of grade II or above (according to Clavien-Dindo's classification) were considered in a follow-up period of up to 30 days after surgery. Major complications were defined when they reached grade III or above. A total of 84 patients were analyzed (57.1% female, 59.7 ± 12.6 years) and 19% were diagnosed with low HGS + low SMI or SMD. Postoperative complications occurred in 51.2%, and these patients presented significantly longer duration of surgery and hospital stay. Major complications were observed in 16.7% of the total number of patients. Binary logistic regression adjusted by age, sex, and tumor staging showed that low SMD, low HGS + low SMI or SMD, and obesity were independent risk factors for postoperative complications, but only low SMD was an independent risk factor for major postoperative complications. Low SMD is an independent risk factor for short-term major complications following surgery in patients with gastric and colorectal cancer. |
| first_indexed | 2024-12-18T02:21:53Z |
| format | Article |
| id | doaj.art-4c73cc6adca74e9db3b3ccf45647c219 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-18T02:21:53Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4c73cc6adca74e9db3b3ccf45647c2192022-12-21T21:24:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01162e024732210.1371/journal.pone.0247322Low skeletal muscle radiodensity is the best predictor for short-term major surgical complications in gastrointestinal surgical cancer: A cohort study.Ana Lúcia Miranda de CarvalhoMaria Cristina GonzalezIasmin Matias de SousaIsabel Pinto Amorim das VirgensGaltieri Otavio Cunha de MedeirosMarília Nelo OliveiraJeane Cristina Alves de Souza DantasAna Paula Trussardi FayhThe aim of this study was to evaluate whether body composition, muscle function, and their association are predictive factors for short-term postoperative complications in patients with gastric and colorectal cancer. A prospective cohort study was conducted with patients undergoing resection of gastric and colorectal tumors. Nutritional status was assessed using Patient-Generated Subjective Global Assessment (PG-SGA) and anthropometric techniques. Low handgrip strength (HGS) was observed when <16kg for women, and <27kg for men. Computed tomography images were used to measure visceral adipose tissue, skeletal muscle index (SMI), and skeletal muscle radiodensity (SMD). Complications of grade II or above (according to Clavien-Dindo's classification) were considered in a follow-up period of up to 30 days after surgery. Major complications were defined when they reached grade III or above. A total of 84 patients were analyzed (57.1% female, 59.7 ± 12.6 years) and 19% were diagnosed with low HGS + low SMI or SMD. Postoperative complications occurred in 51.2%, and these patients presented significantly longer duration of surgery and hospital stay. Major complications were observed in 16.7% of the total number of patients. Binary logistic regression adjusted by age, sex, and tumor staging showed that low SMD, low HGS + low SMI or SMD, and obesity were independent risk factors for postoperative complications, but only low SMD was an independent risk factor for major postoperative complications. Low SMD is an independent risk factor for short-term major complications following surgery in patients with gastric and colorectal cancer.https://doi.org/10.1371/journal.pone.0247322 |
| spellingShingle | Ana Lúcia Miranda de Carvalho Maria Cristina Gonzalez Iasmin Matias de Sousa Isabel Pinto Amorim das Virgens Galtieri Otavio Cunha de Medeiros Marília Nelo Oliveira Jeane Cristina Alves de Souza Dantas Ana Paula Trussardi Fayh Low skeletal muscle radiodensity is the best predictor for short-term major surgical complications in gastrointestinal surgical cancer: A cohort study. PLoS ONE |
| title | Low skeletal muscle radiodensity is the best predictor for short-term major surgical complications in gastrointestinal surgical cancer: A cohort study. |
| title_full | Low skeletal muscle radiodensity is the best predictor for short-term major surgical complications in gastrointestinal surgical cancer: A cohort study. |
| title_fullStr | Low skeletal muscle radiodensity is the best predictor for short-term major surgical complications in gastrointestinal surgical cancer: A cohort study. |
| title_full_unstemmed | Low skeletal muscle radiodensity is the best predictor for short-term major surgical complications in gastrointestinal surgical cancer: A cohort study. |
| title_short | Low skeletal muscle radiodensity is the best predictor for short-term major surgical complications in gastrointestinal surgical cancer: A cohort study. |
| title_sort | low skeletal muscle radiodensity is the best predictor for short term major surgical complications in gastrointestinal surgical cancer a cohort study |
| url | https://doi.org/10.1371/journal.pone.0247322 |
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