Antimicrobial activity, mechanism of action, and methods for stabilisation of defensins as new therapeutic agents
Bioactive compounds, such as antimicrobial peptides (AMPs), have increasingly been used recently to counteract the rapidly increasing incidence of bacterial resistance to usual antibiotics and chemotherapeutics. In humans, endogenous AMPs are part of the immune system and act against pathogens. Defe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Biotechnology & Biotechnological Equipment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/13102818.2019.1611385 |
| _version_ | 1818906604314034176 |
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| author | Meri Amerikova Ivanka Pencheva El-Tibi Vania Maslarska Stanislav Bozhanov Konstantin Tachkov |
| author_facet | Meri Amerikova Ivanka Pencheva El-Tibi Vania Maslarska Stanislav Bozhanov Konstantin Tachkov |
| author_sort | Meri Amerikova |
| collection | DOAJ |
| description | Bioactive compounds, such as antimicrobial peptides (AMPs), have increasingly been used recently to counteract the rapidly increasing incidence of bacterial resistance to usual antibiotics and chemotherapeutics. In humans, endogenous AMPs are part of the immune system and act against pathogens. Defensins compose a class of AMPs that have activity against gram-positive and -negative bacteria, viruses, and fungi. For some, antitumour activity has also been reported. Such characteristics indicate that they represent a potential new class of therapeutic agents against microorganisms, including multidrug resistant pathogens. However, pH and enzymatic degradation and variable tissue distribution of these compounds limit their clinical application. New technologies and different methods have been developed to overcome these limitations and increase their half-life, such as cyclization, lipidation, design of peptidomimetics, synthesis of hybrid peptides, and use of nanocarriers. The objective of this review was to analyse current applications of defensins as antimicrobial agents and their mechanism of action. Moreover, new technologies and methods for stabilizing defensins are discussed. |
| first_indexed | 2024-12-19T21:41:52Z |
| format | Article |
| id | doaj.art-4c78145226714c818626864c0bcd1637 |
| institution | Directory Open Access Journal |
| issn | 1310-2818 1314-3530 |
| language | English |
| last_indexed | 2024-12-19T21:41:52Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Biotechnology & Biotechnological Equipment |
| spelling | doaj.art-4c78145226714c818626864c0bcd16372022-12-21T20:04:38ZengTaylor & Francis GroupBiotechnology & Biotechnological Equipment1310-28181314-35302019-01-0133167168210.1080/13102818.2019.16113851611385Antimicrobial activity, mechanism of action, and methods for stabilisation of defensins as new therapeutic agentsMeri Amerikova0Ivanka Pencheva El-Tibi1Vania Maslarska2Stanislav Bozhanov3Konstantin Tachkov4Medical University of SofiaMedical University of SofiaMedical University of SofiaMedical University of SofiaMedical University of SofiaBioactive compounds, such as antimicrobial peptides (AMPs), have increasingly been used recently to counteract the rapidly increasing incidence of bacterial resistance to usual antibiotics and chemotherapeutics. In humans, endogenous AMPs are part of the immune system and act against pathogens. Defensins compose a class of AMPs that have activity against gram-positive and -negative bacteria, viruses, and fungi. For some, antitumour activity has also been reported. Such characteristics indicate that they represent a potential new class of therapeutic agents against microorganisms, including multidrug resistant pathogens. However, pH and enzymatic degradation and variable tissue distribution of these compounds limit their clinical application. New technologies and different methods have been developed to overcome these limitations and increase their half-life, such as cyclization, lipidation, design of peptidomimetics, synthesis of hybrid peptides, and use of nanocarriers. The objective of this review was to analyse current applications of defensins as antimicrobial agents and their mechanism of action. Moreover, new technologies and methods for stabilizing defensins are discussed.http://dx.doi.org/10.1080/13102818.2019.1611385antimicrobial peptidemultidrug resistancenanoparticleorganometallic complexpeptoid |
| spellingShingle | Meri Amerikova Ivanka Pencheva El-Tibi Vania Maslarska Stanislav Bozhanov Konstantin Tachkov Antimicrobial activity, mechanism of action, and methods for stabilisation of defensins as new therapeutic agents Biotechnology & Biotechnological Equipment antimicrobial peptide multidrug resistance nanoparticle organometallic complex peptoid |
| title | Antimicrobial activity, mechanism of action, and methods for stabilisation of defensins as new therapeutic agents |
| title_full | Antimicrobial activity, mechanism of action, and methods for stabilisation of defensins as new therapeutic agents |
| title_fullStr | Antimicrobial activity, mechanism of action, and methods for stabilisation of defensins as new therapeutic agents |
| title_full_unstemmed | Antimicrobial activity, mechanism of action, and methods for stabilisation of defensins as new therapeutic agents |
| title_short | Antimicrobial activity, mechanism of action, and methods for stabilisation of defensins as new therapeutic agents |
| title_sort | antimicrobial activity mechanism of action and methods for stabilisation of defensins as new therapeutic agents |
| topic | antimicrobial peptide multidrug resistance nanoparticle organometallic complex peptoid |
| url | http://dx.doi.org/10.1080/13102818.2019.1611385 |
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