Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?

The cardiovascular system can be programmed by a diversity of early-life insults, leading to cardiovascular disease (CVD) in adulthood. This notion is now termed developmental origins of health and disease (DOHaD). Emerging evidence indicates hydrogen sulfide (H<sub>2</sub>S), a crucial...

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Main Authors: Chien-Ning Hsu, You-Lin Tain
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Antioxidants
Subjects:
Online Access:https://www.mdpi.com/2076-3921/10/2/247
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author Chien-Ning Hsu
You-Lin Tain
author_facet Chien-Ning Hsu
You-Lin Tain
author_sort Chien-Ning Hsu
collection DOAJ
description The cardiovascular system can be programmed by a diversity of early-life insults, leading to cardiovascular disease (CVD) in adulthood. This notion is now termed developmental origins of health and disease (DOHaD). Emerging evidence indicates hydrogen sulfide (H<sub>2</sub>S), a crucial regulator of cardiovascular homeostasis, plays a pathogenetic role in CVD of developmental origins. Conversely, early H<sub>2</sub>S-based interventions have proved beneficial in preventing adult-onset CVD in animal studies via reversing programming processes by so-called reprogramming. The focus of this review will first summarize the current knowledge on H<sub>2</sub>S implicated in cardiovascular programming. This will be followed by supporting evidence for the links between H<sub>2</sub>S signaling and underlying mechanisms of cardiovascular programming, such as oxidative stress, nitric oxide deficiency, dysregulated nutrient-sensing signals, activation of the renin–angiotensin system, and gut microbiota dysbiosis. It will also provide an overview from animal models regarding how H<sub>2</sub>S-based reprogramming interventions, such as precursors of H<sub>2</sub>S and H<sub>2</sub>S donors, may prevent CVD of developmental origins. A better understanding of cardiovascular programming and recent advances in H<sub>2</sub>S-based interventions might provide the answers to bring down the global burden of CVD.
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spelling doaj.art-4c7971e383f7496e925b4800c95cbab12023-12-03T12:34:00ZengMDPI AGAntioxidants2076-39212021-02-0110224710.3390/antiox10020247Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?Chien-Ning Hsu0You-Lin Tain1Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanThe cardiovascular system can be programmed by a diversity of early-life insults, leading to cardiovascular disease (CVD) in adulthood. This notion is now termed developmental origins of health and disease (DOHaD). Emerging evidence indicates hydrogen sulfide (H<sub>2</sub>S), a crucial regulator of cardiovascular homeostasis, plays a pathogenetic role in CVD of developmental origins. Conversely, early H<sub>2</sub>S-based interventions have proved beneficial in preventing adult-onset CVD in animal studies via reversing programming processes by so-called reprogramming. The focus of this review will first summarize the current knowledge on H<sub>2</sub>S implicated in cardiovascular programming. This will be followed by supporting evidence for the links between H<sub>2</sub>S signaling and underlying mechanisms of cardiovascular programming, such as oxidative stress, nitric oxide deficiency, dysregulated nutrient-sensing signals, activation of the renin–angiotensin system, and gut microbiota dysbiosis. It will also provide an overview from animal models regarding how H<sub>2</sub>S-based reprogramming interventions, such as precursors of H<sub>2</sub>S and H<sub>2</sub>S donors, may prevent CVD of developmental origins. A better understanding of cardiovascular programming and recent advances in H<sub>2</sub>S-based interventions might provide the answers to bring down the global burden of CVD.https://www.mdpi.com/2076-3921/10/2/247hydrogen sulfidecardiovascular diseasehypertensionatherosclerosiscysteinedevelopmental origins of health and disease (DOHaD)
spellingShingle Chien-Ning Hsu
You-Lin Tain
Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?
Antioxidants
hydrogen sulfide
cardiovascular disease
hypertension
atherosclerosis
cysteine
developmental origins of health and disease (DOHaD)
title Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?
title_full Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?
title_fullStr Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?
title_full_unstemmed Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?
title_short Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?
title_sort preventing developmental origins of cardiovascular disease hydrogen sulfide as a potential target
topic hydrogen sulfide
cardiovascular disease
hypertension
atherosclerosis
cysteine
developmental origins of health and disease (DOHaD)
url https://www.mdpi.com/2076-3921/10/2/247
work_keys_str_mv AT chienninghsu preventingdevelopmentaloriginsofcardiovasculardiseasehydrogensulfideasapotentialtarget
AT youlintain preventingdevelopmentaloriginsofcardiovasculardiseasehydrogensulfideasapotentialtarget