Peripheral neuropathy and the role of nerve biopsy: A revisit
Background: Nerve biopsy has been widely used to investigate patients with peripheral neuropathy and in many centers, it is still a part of the diagnostic armamentarium. In this study, the histopathological spectrum of the nerve biopsies received is being revisited to analyze the various clinical an...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=3;spage=339;epage=344;aulast=Pant |
| _version_ | 1819100376344821760 |
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| author | Ishita Pant Karuna Jha Ritika Singh Suman Kushwaha Sujata Chaturvedi |
| author_facet | Ishita Pant Karuna Jha Ritika Singh Suman Kushwaha Sujata Chaturvedi |
| author_sort | Ishita Pant |
| collection | DOAJ |
| description | Background: Nerve biopsy has been widely used to investigate patients with peripheral neuropathy and in many centers, it is still a part of the diagnostic armamentarium. In this study, the histopathological spectrum of the nerve biopsies received is being revisited to analyze the various clinical and pathologic features and also to assess their relevance. Materials and Methods: Retrospective analysis of the data retrieved was done for 74 cases of nerve biopsies. Results: On the basis of the data and histopathological features, broad diagnoses were obtained in 52 cases and further categorized into biopsies being supportive for patient management (including acute and chronic axonopathies and demyelinating neuropathies) and biopsies considered essential for patient management (including vasculitic neuropathies, leprous neuropathies, hereditary neuropathies, and chronic inflammatory demyelinating neuropathies). Nine nerve biopsies did not show any abnormal histopathological features, while 13 nerve biopsies were found to be inadequate for diagnosis, both these groups were categorized as noncontributory. Conclusion: With advanced nerve conduction studies available, nerve biopsy is losing its relevance. However, in our experience, nerve biopsy did complement the clinical findings and nerve conduction studies, with which a close correlation is required to make the histopathology of nerve biopsy more relevant in terms of guiding further specific workup and management. |
| first_indexed | 2024-12-22T01:01:47Z |
| format | Article |
| id | doaj.art-4c7b66939781497caf2599b0f08d3679 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-22T01:01:47Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-4c7b66939781497caf2599b0f08d36792022-12-21T18:44:11ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292018-01-0161333934410.4103/IJPM.IJPM_402_17Peripheral neuropathy and the role of nerve biopsy: A revisitIshita PantKaruna JhaRitika SinghSuman KushwahaSujata ChaturvediBackground: Nerve biopsy has been widely used to investigate patients with peripheral neuropathy and in many centers, it is still a part of the diagnostic armamentarium. In this study, the histopathological spectrum of the nerve biopsies received is being revisited to analyze the various clinical and pathologic features and also to assess their relevance. Materials and Methods: Retrospective analysis of the data retrieved was done for 74 cases of nerve biopsies. Results: On the basis of the data and histopathological features, broad diagnoses were obtained in 52 cases and further categorized into biopsies being supportive for patient management (including acute and chronic axonopathies and demyelinating neuropathies) and biopsies considered essential for patient management (including vasculitic neuropathies, leprous neuropathies, hereditary neuropathies, and chronic inflammatory demyelinating neuropathies). Nine nerve biopsies did not show any abnormal histopathological features, while 13 nerve biopsies were found to be inadequate for diagnosis, both these groups were categorized as noncontributory. Conclusion: With advanced nerve conduction studies available, nerve biopsy is losing its relevance. However, in our experience, nerve biopsy did complement the clinical findings and nerve conduction studies, with which a close correlation is required to make the histopathology of nerve biopsy more relevant in terms of guiding further specific workup and management.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=3;spage=339;epage=344;aulast=PantNerve biopsyperipheral neuropathysural nerve |
| spellingShingle | Ishita Pant Karuna Jha Ritika Singh Suman Kushwaha Sujata Chaturvedi Peripheral neuropathy and the role of nerve biopsy: A revisit Indian Journal of Pathology and Microbiology Nerve biopsy peripheral neuropathy sural nerve |
| title | Peripheral neuropathy and the role of nerve biopsy: A revisit |
| title_full | Peripheral neuropathy and the role of nerve biopsy: A revisit |
| title_fullStr | Peripheral neuropathy and the role of nerve biopsy: A revisit |
| title_full_unstemmed | Peripheral neuropathy and the role of nerve biopsy: A revisit |
| title_short | Peripheral neuropathy and the role of nerve biopsy: A revisit |
| title_sort | peripheral neuropathy and the role of nerve biopsy a revisit |
| topic | Nerve biopsy peripheral neuropathy sural nerve |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=3;spage=339;epage=344;aulast=Pant |
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