Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior
The ventral tenia tecta (vTT) is a component of the olfactory cortex and receives both bottom-up odor signals and top-down signals. However, the roles of the vTT in odor-coding and integration of inputs are poorly understood. Here, we investigated the involvement of the vTT in these processes by rec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/57268 |
| _version_ | 1811252882314362880 |
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| author | Kazuki Shiotani Yuta Tanisumi Koshi Murata Junya Hirokawa Yoshio Sakurai Hiroyuki Manabe |
| author_facet | Kazuki Shiotani Yuta Tanisumi Koshi Murata Junya Hirokawa Yoshio Sakurai Hiroyuki Manabe |
| author_sort | Kazuki Shiotani |
| collection | DOAJ |
| description | The ventral tenia tecta (vTT) is a component of the olfactory cortex and receives both bottom-up odor signals and top-down signals. However, the roles of the vTT in odor-coding and integration of inputs are poorly understood. Here, we investigated the involvement of the vTT in these processes by recording the activity from individual vTT neurons during the performance of learned odor-guided reward-directed tasks in mice. We report that individual vTT cells are highly tuned to a specific behavioral epoch of learned tasks, whereby the duration of increased firing correlated with the temporal length of the behavioral epoch. The peak time for increased firing among recorded vTT cells encompassed almost the entire temporal window of the tasks. Collectively, our results indicate that vTT cells are selectively activated during a specific behavioral context and that the function of the vTT changes dynamically in a context-dependent manner during goal-directed behaviors. |
| first_indexed | 2024-04-12T16:42:15Z |
| format | Article |
| id | doaj.art-4c7f20a9a86a49eaa67219e5d9184606 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:42:15Z |
| publishDate | 2020-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-4c7f20a9a86a49eaa67219e5d91846062022-12-22T03:24:44ZengeLife Sciences Publications LtdeLife2050-084X2020-08-01910.7554/eLife.57268Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behaviorKazuki Shiotani0https://orcid.org/0000-0001-5596-5609Yuta Tanisumi1Koshi Murata2Junya Hirokawa3https://orcid.org/0000-0003-1238-5713Yoshio Sakurai4Hiroyuki Manabe5https://orcid.org/0000-0002-3910-4849Laboratory of Neural Information, Graduate School of Brain Science, Doshisha University, Kyoto, Japan; Research Fellow of the Japan Society for the Promotion of Science, Tokyo, JapanLaboratory of Neural Information, Graduate School of Brain Science, Doshisha University, Kyoto, Japan; Research Fellow of the Japan Society for the Promotion of Science, Tokyo, JapanLaboratory of Neural Information, Graduate School of Brain Science, Doshisha University, Kyoto, Japan; Division of Brain Structure and Function, Faculty of Medical Sciences, University of Fukui, Fukui, JapanLaboratory of Neural Information, Graduate School of Brain Science, Doshisha University, Kyoto, JapanLaboratory of Neural Information, Graduate School of Brain Science, Doshisha University, Kyoto, JapanLaboratory of Neural Information, Graduate School of Brain Science, Doshisha University, Kyoto, JapanThe ventral tenia tecta (vTT) is a component of the olfactory cortex and receives both bottom-up odor signals and top-down signals. However, the roles of the vTT in odor-coding and integration of inputs are poorly understood. Here, we investigated the involvement of the vTT in these processes by recording the activity from individual vTT neurons during the performance of learned odor-guided reward-directed tasks in mice. We report that individual vTT cells are highly tuned to a specific behavioral epoch of learned tasks, whereby the duration of increased firing correlated with the temporal length of the behavioral epoch. The peak time for increased firing among recorded vTT cells encompassed almost the entire temporal window of the tasks. Collectively, our results indicate that vTT cells are selectively activated during a specific behavioral context and that the function of the vTT changes dynamically in a context-dependent manner during goal-directed behaviors.https://elifesciences.org/articles/57268tenia tectaolfactory cortexelectrophysiology |
| spellingShingle | Kazuki Shiotani Yuta Tanisumi Koshi Murata Junya Hirokawa Yoshio Sakurai Hiroyuki Manabe Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior eLife tenia tecta olfactory cortex electrophysiology |
| title | Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior |
| title_full | Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior |
| title_fullStr | Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior |
| title_full_unstemmed | Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior |
| title_short | Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior |
| title_sort | tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal directed behavior |
| topic | tenia tecta olfactory cortex electrophysiology |
| url | https://elifesciences.org/articles/57268 |
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