Age-dependent pattern of cerebellar susceptibility to bilirubin neurotoxicity in vivo in mice

Age-dependent pattern of cerebellar susceptibility to bilirubin neurotoxicity in vivo in mice

Neonatal jaundice is caused by high levels of unconjugated bilirubin. It is usually a temporary condition caused by delayed induction of UGT1A1, which conjugates bilirubin in the liver. To reduce bilirubin levels, affected babies are exposed to phototherapy (PT), which converts toxic bilirubin into...

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Bibliographic Details
Main Authors: Giulia Bortolussi, Gabriele Baj, Simone Vodret, Giulia Viviani, Tamara Bittolo, Andrés F. Muro
Format: Article
Language:English
Published: The Company of Biologists 2014-09-01
Series:Disease Models & Mechanisms
Subjects:
Neonatal jaundice
Ugt1
Phototherapy
BIND
Mouse model
Online Access:http://dmm.biologists.org/content/7/9/1057

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