Clinical and epidemiological characterization of Chronic Myeloid Leukemia at the Teaching Hospital "Abel Santamaría Cuadrado" 1987-2018
Introduction: chronic myeloid leukemia, also known as myelogenous or chronic granulocytic leukemia, is defined as a malignant myeloproliferative hematologic myelogenous or chronic granulocytic leukemia, is defined as a clonal malignant myeloproliferative hematologic neoplastic disease of pluripoten...
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| Format: | Article |
| Language: | English |
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Universidad de Ciencias Médicas de Pinar del Río
2022-12-01
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| Series: | Universidad Médica Pinareña |
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| Online Access: | https://revgaleno.sld.cu/index.php/ump/article/view/918 |
| _version_ | 1797866899507249152 |
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| author | Dayand Marín Hernández Yailin Martínez Bazabe Alejandro Marín García Osniel González Hernandez Yanet Montano Medina |
| author_facet | Dayand Marín Hernández Yailin Martínez Bazabe Alejandro Marín García Osniel González Hernandez Yanet Montano Medina |
| author_sort | Dayand Marín Hernández |
| collection | DOAJ |
| description | Introduction: chronic myeloid leukemia, also known as myelogenous or chronic granulocytic leukemia, is defined as a malignant myeloproliferative hematologic
myelogenous or chronic granulocytic leukemia, is defined as a clonal malignant myeloproliferative hematologic neoplastic disease of pluripotent stem cells classified according to the latest World Health Organization classification within the group of chronic myeloproliferative neoplasms.
Objective: to clinically and epidemiologically characterize chronic myeloid leukemia in the General Teaching Hospital "Abel Santamaría Cuadrado" of Pinar del Río, in the period 1987-2018.
Methods: a descriptive, cross-sectional study was carried out including patients diagnosed with CML. The sample was constituted by a total of 105 cases. Theoretical, empirical and statistical methods were taken into account to collect the information, the results were processed in a computer and were taken to tables and graphs for better study and understanding.
Results: the predominant age group was over 40 years old, with an average age of 54,68 years, and 54 % of the cases were male and 54 % female. Twenty-two cytogenetic studies were performed, resulting in 21 positive results, and 17 molecular rearrangements to BCR/ABL, resulting in 16 positive results. Hydroxyurea is the most commonly used treatment at debut and only 15 patients have been incorporated into the Imatinib protocol. Survival over 5 years was 33,3 % and over 10 years was 13,3 %.
Conclusions: it was found that it is necessary to incorporate more patients to the imatinib protocol, which would result in better responses to treatment and better overall survival rates. |
| first_indexed | 2024-04-09T23:32:46Z |
| format | Article |
| id | doaj.art-4c83f1f1fdf64bc4b4f1a1541d367ea8 |
| institution | Directory Open Access Journal |
| issn | 1990-7990 |
| language | English |
| last_indexed | 2024-04-09T23:32:46Z |
| publishDate | 2022-12-01 |
| publisher | Universidad de Ciencias Médicas de Pinar del Río |
| record_format | Article |
| series | Universidad Médica Pinareña |
| spelling | doaj.art-4c83f1f1fdf64bc4b4f1a1541d367ea82023-03-21T03:32:11ZengUniversidad de Ciencias Médicas de Pinar del RíoUniversidad Médica Pinareña1990-79902022-12-01184e918e918663Clinical and epidemiological characterization of Chronic Myeloid Leukemia at the Teaching Hospital "Abel Santamaría Cuadrado" 1987-2018Dayand Marín Hernández0Yailin Martínez Bazabe1Alejandro Marín García2Osniel González Hernandez3Yanet Montano Medina4Universidad de Ciencias Médicas de Pinar del Río. Hospital General Docente “Abel Santamaría Cuadrado”. Pinar del RíoUniversidad de Ciencias Médicas de Pinar del Río. Hospital General Docente “Abel Santamaría Cuadrado”. Pinar del RíoUniversidad de Ciencias Médicas de Pinar del Río. Facultad de Ciencias Médicas “Dr. Ernesto Che Guevara de la Serna”. Pinar del RíoUniversidad de Ciencias Médicas de Pinar del Río. Hospital General Docente “Abel Santamaría Cuadrado”. Pinar del RíoUniversidad de Ciencias Médicas de Pinar del Río. Hospital General Docente “Abel Santamaría Cuadrado”. Pinar del RíoIntroduction: chronic myeloid leukemia, also known as myelogenous or chronic granulocytic leukemia, is defined as a malignant myeloproliferative hematologic myelogenous or chronic granulocytic leukemia, is defined as a clonal malignant myeloproliferative hematologic neoplastic disease of pluripotent stem cells classified according to the latest World Health Organization classification within the group of chronic myeloproliferative neoplasms. Objective: to clinically and epidemiologically characterize chronic myeloid leukemia in the General Teaching Hospital "Abel Santamaría Cuadrado" of Pinar del Río, in the period 1987-2018. Methods: a descriptive, cross-sectional study was carried out including patients diagnosed with CML. The sample was constituted by a total of 105 cases. Theoretical, empirical and statistical methods were taken into account to collect the information, the results were processed in a computer and were taken to tables and graphs for better study and understanding. Results: the predominant age group was over 40 years old, with an average age of 54,68 years, and 54 % of the cases were male and 54 % female. Twenty-two cytogenetic studies were performed, resulting in 21 positive results, and 17 molecular rearrangements to BCR/ABL, resulting in 16 positive results. Hydroxyurea is the most commonly used treatment at debut and only 15 patients have been incorporated into the Imatinib protocol. Survival over 5 years was 33,3 % and over 10 years was 13,3 %. Conclusions: it was found that it is necessary to incorporate more patients to the imatinib protocol, which would result in better responses to treatment and better overall survival rates.https://revgaleno.sld.cu/index.php/ump/article/view/918leucemianeoplasiashidroxiurea. |
| spellingShingle | Dayand Marín Hernández Yailin Martínez Bazabe Alejandro Marín García Osniel González Hernandez Yanet Montano Medina Clinical and epidemiological characterization of Chronic Myeloid Leukemia at the Teaching Hospital "Abel Santamaría Cuadrado" 1987-2018 Universidad Médica Pinareña leucemia neoplasias hidroxiurea. |
| title | Clinical and epidemiological characterization of Chronic Myeloid Leukemia at the Teaching Hospital "Abel Santamaría Cuadrado" 1987-2018 |
| title_full | Clinical and epidemiological characterization of Chronic Myeloid Leukemia at the Teaching Hospital "Abel Santamaría Cuadrado" 1987-2018 |
| title_fullStr | Clinical and epidemiological characterization of Chronic Myeloid Leukemia at the Teaching Hospital "Abel Santamaría Cuadrado" 1987-2018 |
| title_full_unstemmed | Clinical and epidemiological characterization of Chronic Myeloid Leukemia at the Teaching Hospital "Abel Santamaría Cuadrado" 1987-2018 |
| title_short | Clinical and epidemiological characterization of Chronic Myeloid Leukemia at the Teaching Hospital "Abel Santamaría Cuadrado" 1987-2018 |
| title_sort | clinical and epidemiological characterization of chronic myeloid leukemia at the teaching hospital abel santamaria cuadrado 1987 2018 |
| topic | leucemia neoplasias hidroxiurea. |
| url | https://revgaleno.sld.cu/index.php/ump/article/view/918 |
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