Hepatitis D virus infections among injecting drug users with and without human immunodeficiency virus infection in Taiwan
In Taiwan, injecting drug use has been the main route of human immunodeficiency virus (HIV) transmission since 2005, with hepatitis B virus (HBV) and hepatitis D virus (HDV) also having similar transmission routes. This has now become an important public health issue. The aim of this study is to exp...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-10-01
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| Series: | Kaohsiung Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X16301589 |
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| author | Meng-Hsuan Hsieh Shu-Chi Wang Ming-Yen Hsieh Chung-Feng Huang Ming-Lun Yeh Jeng-Fu Yang Ko Chang Wei-Ru Lin Chun-Yu Lin Tun-Chieh Chen Jee-Fu Huang Chia-Yen Dai Jih-Jin Tsai Wan-Long Chuang Ming-Lung Yu |
| author_facet | Meng-Hsuan Hsieh Shu-Chi Wang Ming-Yen Hsieh Chung-Feng Huang Ming-Lun Yeh Jeng-Fu Yang Ko Chang Wei-Ru Lin Chun-Yu Lin Tun-Chieh Chen Jee-Fu Huang Chia-Yen Dai Jih-Jin Tsai Wan-Long Chuang Ming-Lung Yu |
| author_sort | Meng-Hsuan Hsieh |
| collection | DOAJ |
| description | In Taiwan, injecting drug use has been the main route of human immunodeficiency virus (HIV) transmission since 2005, with hepatitis B virus (HBV) and hepatitis D virus (HDV) also having similar transmission routes. This has now become an important public health issue. The aim of this study is to explore the conditions of HDV infections between injecting drug users (IDUs) with and without HIV infection in Southern Taiwan. In this study, 87 IDUs were enrolled, including 27 anti-HDV seronegative IDUs and 60 anti-HDV seropositive IDUs, and the results of their liver function tests, CD4 cell counts, and anti-HIV and HIV RNA levels were analyzed. The prevalence of anti-HDV seropositivity among hepatitis B surface antigen (HBsAg) seropositive IDUs in this study was 68.9% (60/87). The prevalence rate of anti-HDV seropositive IDUs among anti-HIV seronegative and anti-HIV seropositive cases was 40.0% (12/30) and 84.2% (48/57), respectively. Anti-HIV seropositivity was related to anti-HDV seropositivity (odds ratio = 9.34, 95% confidence interval = 2.67–31.59, p < 0.001). Among IDUs with HIV infection, there was no significant difference in CD4 cell counts and HIV RNA viral load between HBsAg-positive patients with anti-HDV seronegativity and those with anti-HDV seropositivity. In conclusion, the prevalence of HDV infection among IDUs is higher among IDUs with HIV infection. Because anti-HIV seropositivity is significantly related to anti-HDV seropositivity, HDV infection among IDUs is still important. We suggest that for IDUs, HBsAg and anti-HDV should be monitored closely. |
| first_indexed | 2024-12-19T21:19:24Z |
| format | Article |
| id | doaj.art-4c85a303a27242c584e82d367d6d9357 |
| institution | Directory Open Access Journal |
| issn | 1607-551X |
| language | English |
| last_indexed | 2024-12-19T21:19:24Z |
| publishDate | 2016-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-4c85a303a27242c584e82d367d6d93572022-12-21T20:05:15ZengWileyKaohsiung Journal of Medical Sciences1607-551X2016-10-01321052653010.1016/j.kjms.2016.08.004Hepatitis D virus infections among injecting drug users with and without human immunodeficiency virus infection in TaiwanMeng-Hsuan Hsieh0Shu-Chi Wang1Ming-Yen Hsieh2Chung-Feng Huang3Ming-Lun Yeh4Jeng-Fu Yang5Ko Chang6Wei-Ru Lin7Chun-Yu Lin8Tun-Chieh Chen9Jee-Fu Huang10Chia-Yen Dai11Jih-Jin Tsai12Wan-Long Chuang13Ming-Lung Yu14Health Management Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, TaiwanHepatitis Center and Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung City, TaiwanSchool of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung City, TaiwanHealth Management Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, TaiwanSchool of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, TaiwanSchool of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, TaiwanSchool of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, TaiwanSchool of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, TaiwanHealth Management Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, TaiwanSchool of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, TaiwanSchool of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, TaiwanSchool of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, TaiwanIn Taiwan, injecting drug use has been the main route of human immunodeficiency virus (HIV) transmission since 2005, with hepatitis B virus (HBV) and hepatitis D virus (HDV) also having similar transmission routes. This has now become an important public health issue. The aim of this study is to explore the conditions of HDV infections between injecting drug users (IDUs) with and without HIV infection in Southern Taiwan. In this study, 87 IDUs were enrolled, including 27 anti-HDV seronegative IDUs and 60 anti-HDV seropositive IDUs, and the results of their liver function tests, CD4 cell counts, and anti-HIV and HIV RNA levels were analyzed. The prevalence of anti-HDV seropositivity among hepatitis B surface antigen (HBsAg) seropositive IDUs in this study was 68.9% (60/87). The prevalence rate of anti-HDV seropositive IDUs among anti-HIV seronegative and anti-HIV seropositive cases was 40.0% (12/30) and 84.2% (48/57), respectively. Anti-HIV seropositivity was related to anti-HDV seropositivity (odds ratio = 9.34, 95% confidence interval = 2.67–31.59, p < 0.001). Among IDUs with HIV infection, there was no significant difference in CD4 cell counts and HIV RNA viral load between HBsAg-positive patients with anti-HDV seronegativity and those with anti-HDV seropositivity. In conclusion, the prevalence of HDV infection among IDUs is higher among IDUs with HIV infection. Because anti-HIV seropositivity is significantly related to anti-HDV seropositivity, HDV infection among IDUs is still important. We suggest that for IDUs, HBsAg and anti-HDV should be monitored closely.http://www.sciencedirect.com/science/article/pii/S1607551X16301589Hepatitis B virusHepatitis D virusHuman immunodeficiency virusInjecting drug usersTaiwan |
| spellingShingle | Meng-Hsuan Hsieh Shu-Chi Wang Ming-Yen Hsieh Chung-Feng Huang Ming-Lun Yeh Jeng-Fu Yang Ko Chang Wei-Ru Lin Chun-Yu Lin Tun-Chieh Chen Jee-Fu Huang Chia-Yen Dai Jih-Jin Tsai Wan-Long Chuang Ming-Lung Yu Hepatitis D virus infections among injecting drug users with and without human immunodeficiency virus infection in Taiwan Kaohsiung Journal of Medical Sciences Hepatitis B virus Hepatitis D virus Human immunodeficiency virus Injecting drug users Taiwan |
| title | Hepatitis D virus infections among injecting drug users with and without human immunodeficiency virus infection in Taiwan |
| title_full | Hepatitis D virus infections among injecting drug users with and without human immunodeficiency virus infection in Taiwan |
| title_fullStr | Hepatitis D virus infections among injecting drug users with and without human immunodeficiency virus infection in Taiwan |
| title_full_unstemmed | Hepatitis D virus infections among injecting drug users with and without human immunodeficiency virus infection in Taiwan |
| title_short | Hepatitis D virus infections among injecting drug users with and without human immunodeficiency virus infection in Taiwan |
| title_sort | hepatitis d virus infections among injecting drug users with and without human immunodeficiency virus infection in taiwan |
| topic | Hepatitis B virus Hepatitis D virus Human immunodeficiency virus Injecting drug users Taiwan |
| url | http://www.sciencedirect.com/science/article/pii/S1607551X16301589 |
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