Endocannabinoid modulation of allergic responses: Focus on the control of FcεRI-mediated mast cell activation
Allergic reactions are highly prevalent pathologies initiated by the production of IgE antibodies against harmless antigens (allergens) and the activation of the high-affinity IgE receptor (FcεRI) expressed in the surface of basophils and mast cells (MCs). Research on the mechanisms of negative cont...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | European Journal of Cell Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0171933523000390 |
| _version_ | 1827920701804249088 |
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| author | Rubi Monserrat Osorio-Perez Gabriela Rodríguez-Manzo Zyanya P. Espinosa-Riquer Silvia L. Cruz Claudia González-Espinosa |
| author_facet | Rubi Monserrat Osorio-Perez Gabriela Rodríguez-Manzo Zyanya P. Espinosa-Riquer Silvia L. Cruz Claudia González-Espinosa |
| author_sort | Rubi Monserrat Osorio-Perez |
| collection | DOAJ |
| description | Allergic reactions are highly prevalent pathologies initiated by the production of IgE antibodies against harmless antigens (allergens) and the activation of the high-affinity IgE receptor (FcεRI) expressed in the surface of basophils and mast cells (MCs). Research on the mechanisms of negative control of those exacerbated inflammatory reactions has been intense in recent years. Endocannabinoids (eCBs) show important regulatory effects on MC-mediated immune responses, mainly inhibiting the production of pro-inflammatory mediators. However, the description of the molecular mechanisms involved in eCB control of MC activation is far from complete. In this review, we aim to summarize the available information regarding the role of eCBs in the modulation of FcεRI-dependent activation of that cell type, emphasizing the description of the eCB system and the existence of some of its elements in MCs. Unique characteristics of the eCB system and cannabinoid receptors (CBRs) localization and signaling in MCs are mentioned. The described and putative points of cross-talk between CBRs and FcεRI signaling cascades are also presented. Finally, we discuss some important considerations in the study of the effects of eCBs in MCs and the perspectives in the field. |
| first_indexed | 2024-03-13T04:14:30Z |
| format | Article |
| id | doaj.art-4c85f8b0e6a84734a741a400d2e2cb19 |
| institution | Directory Open Access Journal |
| issn | 0171-9335 |
| language | English |
| last_indexed | 2024-03-13T04:14:30Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Cell Biology |
| spelling | doaj.art-4c85f8b0e6a84734a741a400d2e2cb192023-06-21T06:51:00ZengElsevierEuropean Journal of Cell Biology0171-93352023-06-011022151324Endocannabinoid modulation of allergic responses: Focus on the control of FcεRI-mediated mast cell activationRubi Monserrat Osorio-Perez0Gabriela Rodríguez-Manzo1Zyanya P. Espinosa-Riquer2Silvia L. Cruz3Claudia González-Espinosa4Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Unidad Sede Sur, Calzada de los Tenorios No. 235, Col. Granjas Coapa, Tlalpan, CP 14330 Mexico City, MexicoDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Unidad Sede Sur, Calzada de los Tenorios No. 235, Col. Granjas Coapa, Tlalpan, CP 14330 Mexico City, MexicoDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Unidad Sede Sur, Calzada de los Tenorios No. 235, Col. Granjas Coapa, Tlalpan, CP 14330 Mexico City, MexicoDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Unidad Sede Sur, Calzada de los Tenorios No. 235, Col. Granjas Coapa, Tlalpan, CP 14330 Mexico City, MexicoCorrespondence to: Departamento de Farmacobiología, Cinvestav, Mexico.; Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del IPN, Unidad Sede Sur, Calzada de los Tenorios No. 235, Col. Granjas Coapa, Tlalpan, CP 14330 Mexico City, MexicoAllergic reactions are highly prevalent pathologies initiated by the production of IgE antibodies against harmless antigens (allergens) and the activation of the high-affinity IgE receptor (FcεRI) expressed in the surface of basophils and mast cells (MCs). Research on the mechanisms of negative control of those exacerbated inflammatory reactions has been intense in recent years. Endocannabinoids (eCBs) show important regulatory effects on MC-mediated immune responses, mainly inhibiting the production of pro-inflammatory mediators. However, the description of the molecular mechanisms involved in eCB control of MC activation is far from complete. In this review, we aim to summarize the available information regarding the role of eCBs in the modulation of FcεRI-dependent activation of that cell type, emphasizing the description of the eCB system and the existence of some of its elements in MCs. Unique characteristics of the eCB system and cannabinoid receptors (CBRs) localization and signaling in MCs are mentioned. The described and putative points of cross-talk between CBRs and FcεRI signaling cascades are also presented. Finally, we discuss some important considerations in the study of the effects of eCBs in MCs and the perspectives in the field.http://www.sciencedirect.com/science/article/pii/S0171933523000390Mast cellsEndocannabinoidsSignal transductionBioactive lipidsCannabinoid receptorsIgE receptor |
| spellingShingle | Rubi Monserrat Osorio-Perez Gabriela Rodríguez-Manzo Zyanya P. Espinosa-Riquer Silvia L. Cruz Claudia González-Espinosa Endocannabinoid modulation of allergic responses: Focus on the control of FcεRI-mediated mast cell activation European Journal of Cell Biology Mast cells Endocannabinoids Signal transduction Bioactive lipids Cannabinoid receptors IgE receptor |
| title | Endocannabinoid modulation of allergic responses: Focus on the control of FcεRI-mediated mast cell activation |
| title_full | Endocannabinoid modulation of allergic responses: Focus on the control of FcεRI-mediated mast cell activation |
| title_fullStr | Endocannabinoid modulation of allergic responses: Focus on the control of FcεRI-mediated mast cell activation |
| title_full_unstemmed | Endocannabinoid modulation of allergic responses: Focus on the control of FcεRI-mediated mast cell activation |
| title_short | Endocannabinoid modulation of allergic responses: Focus on the control of FcεRI-mediated mast cell activation |
| title_sort | endocannabinoid modulation of allergic responses focus on the control of fcεri mediated mast cell activation |
| topic | Mast cells Endocannabinoids Signal transduction Bioactive lipids Cannabinoid receptors IgE receptor |
| url | http://www.sciencedirect.com/science/article/pii/S0171933523000390 |
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