Acute Myeloid Leukemia in a Patient with Ovarian Carcinoma
The occurrence of myelodysplastic syndrome or acute myeloid leukemia has been reported after treatment with cytotoxic alkylating agent-based chemotherapy for solid tumors. We report a 50-year-old woman presented with abdominal distension, vomiting, and fatique. The abdominal tomography showed bilate...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2013-08-01
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| Series: | Namık Kemal Tıp Dergisi |
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http://namikkemalmedj.com/archives/archive-detail/article-preview/acute-myeloid-leukemia-in-a-patient-with-ovarian-c/41581
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| _version_ | 1797912638653464576 |
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| author | Serdal Korkmaz Saadettin Kiliçkap Safak Sahin Mehmet Sencan |
| author_facet | Serdal Korkmaz Saadettin Kiliçkap Safak Sahin Mehmet Sencan |
| author_sort | Serdal Korkmaz |
| collection | DOAJ |
| description | The occurrence of myelodysplastic syndrome or acute myeloid leukemia has been reported after treatment with cytotoxic alkylating agent-based chemotherapy for solid tumors. We report a 50-year-old woman presented with abdominal distension, vomiting, and fatique. The abdominal tomography showed bilaterally ovarian masses and ascite. Surgery was performed and histopathology of the ovarian mass revealed moderately differentiated papillary adenocarcinoma of ovarian. The patient was treated with chemotherapy combination including paclitaxel and carboplatin for six cycles. At 4 years after chemotherapy, recurrence of the primary disease developed. She received carboplatin and paclitaxel. Two years later, complete blood count showed leukocyte count 15.700 /mm3 (15% myeloblasts), hemoglobin 8.7 g/dL, and platelet count 88.000 /mm3. Bone marrow examination and flow cytometry analysis were consistent with acute myeloid leukemia. Standard induction chemotherapy with idarubicin and cytosine arabinoside was administered with failure to achieve complete remission. At the follow-up, the patient died due to prolonged febrile neutropenia. In conclusion, patients who were treated with high dose or long term alkylating agents should particularly follow-up for secondary tumors. |
| first_indexed | 2024-04-10T11:58:53Z |
| format | Article |
| id | doaj.art-4c860b7362a840a8b0d6850471f8fbc8 |
| institution | Directory Open Access Journal |
| issn | 2587-0262 |
| language | English |
| last_indexed | 2024-04-10T11:58:53Z |
| publishDate | 2013-08-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Namık Kemal Tıp Dergisi |
| spelling | doaj.art-4c860b7362a840a8b0d6850471f8fbc82023-02-15T16:16:41ZengGalenos YayincilikNamık Kemal Tıp Dergisi2587-02622013-08-011212312613049054Acute Myeloid Leukemia in a Patient with Ovarian CarcinomaSerdal Korkmaz0Saadettin Kiliçkap1Safak Sahin2Mehmet Sencan3 Cumhuriyet University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Sivas, Turkey Cumhuriyet University, Faculty of Medicine, Department of Internal Medicine, Division of Oncology, Sivas, Turkey Gaziosmanpaşa University, Faculty of Medicine, Department of Internal Medicine, Tokat, Turkey Cumhuriyet University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Sivas, Turkey The occurrence of myelodysplastic syndrome or acute myeloid leukemia has been reported after treatment with cytotoxic alkylating agent-based chemotherapy for solid tumors. We report a 50-year-old woman presented with abdominal distension, vomiting, and fatique. The abdominal tomography showed bilaterally ovarian masses and ascite. Surgery was performed and histopathology of the ovarian mass revealed moderately differentiated papillary adenocarcinoma of ovarian. The patient was treated with chemotherapy combination including paclitaxel and carboplatin for six cycles. At 4 years after chemotherapy, recurrence of the primary disease developed. She received carboplatin and paclitaxel. Two years later, complete blood count showed leukocyte count 15.700 /mm3 (15% myeloblasts), hemoglobin 8.7 g/dL, and platelet count 88.000 /mm3. Bone marrow examination and flow cytometry analysis were consistent with acute myeloid leukemia. Standard induction chemotherapy with idarubicin and cytosine arabinoside was administered with failure to achieve complete remission. At the follow-up, the patient died due to prolonged febrile neutropenia. In conclusion, patients who were treated with high dose or long term alkylating agents should particularly follow-up for secondary tumors. http://namikkemalmedj.com/archives/archive-detail/article-preview/acute-myeloid-leukemia-in-a-patient-with-ovarian-c/41581 ovarian carcinomachemotherapyalkylating agentsacute myeloid leukemia |
| spellingShingle | Serdal Korkmaz Saadettin Kiliçkap Safak Sahin Mehmet Sencan Acute Myeloid Leukemia in a Patient with Ovarian Carcinoma Namık Kemal Tıp Dergisi ovarian carcinoma chemotherapy alkylating agents acute myeloid leukemia |
| title | Acute Myeloid Leukemia in a Patient with Ovarian Carcinoma |
| title_full | Acute Myeloid Leukemia in a Patient with Ovarian Carcinoma |
| title_fullStr | Acute Myeloid Leukemia in a Patient with Ovarian Carcinoma |
| title_full_unstemmed | Acute Myeloid Leukemia in a Patient with Ovarian Carcinoma |
| title_short | Acute Myeloid Leukemia in a Patient with Ovarian Carcinoma |
| title_sort | acute myeloid leukemia in a patient with ovarian carcinoma |
| topic | ovarian carcinoma chemotherapy alkylating agents acute myeloid leukemia |
| url |
http://namikkemalmedj.com/archives/archive-detail/article-preview/acute-myeloid-leukemia-in-a-patient-with-ovarian-c/41581
|
| work_keys_str_mv | AT serdalkorkmaz acutemyeloidleukemiainapatientwithovariancarcinoma AT saadettinkilickap acutemyeloidleukemiainapatientwithovariancarcinoma AT safaksahin acutemyeloidleukemiainapatientwithovariancarcinoma AT mehmetsencan acutemyeloidleukemiainapatientwithovariancarcinoma |