New secoiridoid ester of swertiamarin and secoxyloganic acid with hepatoprotective activity from Centaurium spicatum L.
Context: Centaurium spicatum (L.) Fritsch (Gentianaceae) is an annual herb occurring in Southern Europe and Northern Africa where it is used in traditional medicine for treatment of numerous illness. Aims: To isolate compounds from C. spicatum having hepatoprotective activity. Methods: Structu...
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| Format: | Article |
| Language: | English |
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GarVal Editorial Ltda.
2015-06-01
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| Series: | Journal of Pharmacy & Pharmacognosy Research |
| Subjects: | |
| Online Access: | http://jppres.com/jppres/pdf/vol3/jppres15.058_3.3.69.pdf |
| _version_ | 1828315398671433728 |
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| author | Ahmed E. Allam Alaa M. Nafady Mohamed A. El-Shanawany Fumide Takano Tomihisa Ohta |
| author_facet | Ahmed E. Allam Alaa M. Nafady Mohamed A. El-Shanawany Fumide Takano Tomihisa Ohta |
| author_sort | Ahmed E. Allam |
| collection | DOAJ |
| description | Context: Centaurium spicatum (L.) Fritsch (Gentianaceae) is an annual herb occurring in Southern Europe and Northern Africa where it is used in traditional medicine for treatment of numerous illness.
Aims: To isolate compounds from C. spicatum having hepatoprotective activity.
Methods: Structure elucidation of the new compound was established on the basis of 1D and 2D NMR analyses including 1H-, 13C- NMR, DEPT-135 NMR, HMQC, HMBC and H- H HOHAHA experiments in addition to FAB+ and HRFAB+ Mass spectrometry. In vivo transaminases inhibition activity was carried out.
Results: A new ester of swertiamarin and secoxyloganic acid (1) was isolated from C. spicatum in addition to its known components secoiridoids swertiamarin (2) and secoxyloganic acid (3). All tested secoiridoids have transaminases inhibition activity with different values for each compound 1, 2, 3 (86, 83, 81%) for SGOT and (96, 93, 91%) for SGPT, respectively.
Conclusions: The new ester compound from C. spicatum has hepatoprotective activity over than its components. |
| first_indexed | 2024-04-13T16:59:24Z |
| format | Article |
| id | doaj.art-4c86cfea6f9041b091ce63ce23fceb2e |
| institution | Directory Open Access Journal |
| issn | 0719-4250 |
| language | English |
| last_indexed | 2024-04-13T16:59:24Z |
| publishDate | 2015-06-01 |
| publisher | GarVal Editorial Ltda. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmacognosy Research |
| spelling | doaj.art-4c86cfea6f9041b091ce63ce23fceb2e2022-12-22T02:38:42ZengGarVal Editorial Ltda.Journal of Pharmacy & Pharmacognosy Research0719-42502015-06-01336976New secoiridoid ester of swertiamarin and secoxyloganic acid with hepatoprotective activity from Centaurium spicatum L.Ahmed E. Allam0Alaa M. Nafady1Mohamed A. El-Shanawany2Fumide Takano3Tomihisa Ohta4Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, EgyptDepartment of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, EgyptDepartment of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, EgyptLaboratory of Pharmacognosy and Chemistry of Natural Products, School of Pharmaceutical Sciences, Kanazawa University, Kanazawa 920-1192, JapanLaboratory of Pharmacognosy and Chemistry of Natural Products, School of Pharmaceutical Sciences, Kanazawa University, Kanazawa 920-1192, JapanContext: Centaurium spicatum (L.) Fritsch (Gentianaceae) is an annual herb occurring in Southern Europe and Northern Africa where it is used in traditional medicine for treatment of numerous illness. Aims: To isolate compounds from C. spicatum having hepatoprotective activity. Methods: Structure elucidation of the new compound was established on the basis of 1D and 2D NMR analyses including 1H-, 13C- NMR, DEPT-135 NMR, HMQC, HMBC and H- H HOHAHA experiments in addition to FAB+ and HRFAB+ Mass spectrometry. In vivo transaminases inhibition activity was carried out. Results: A new ester of swertiamarin and secoxyloganic acid (1) was isolated from C. spicatum in addition to its known components secoiridoids swertiamarin (2) and secoxyloganic acid (3). All tested secoiridoids have transaminases inhibition activity with different values for each compound 1, 2, 3 (86, 83, 81%) for SGOT and (96, 93, 91%) for SGPT, respectively. Conclusions: The new ester compound from C. spicatum has hepatoprotective activity over than its components.http://jppres.com/jppres/pdf/vol3/jppres15.058_3.3.69.pdfCentaurium spicatumester of swertiamarin and secoxyloganic acidhepatoprotective activityNMR analysis |
| spellingShingle | Ahmed E. Allam Alaa M. Nafady Mohamed A. El-Shanawany Fumide Takano Tomihisa Ohta New secoiridoid ester of swertiamarin and secoxyloganic acid with hepatoprotective activity from Centaurium spicatum L. Journal of Pharmacy & Pharmacognosy Research Centaurium spicatum ester of swertiamarin and secoxyloganic acid hepatoprotective activity NMR analysis |
| title | New secoiridoid ester of swertiamarin and secoxyloganic acid with hepatoprotective activity from Centaurium spicatum L. |
| title_full | New secoiridoid ester of swertiamarin and secoxyloganic acid with hepatoprotective activity from Centaurium spicatum L. |
| title_fullStr | New secoiridoid ester of swertiamarin and secoxyloganic acid with hepatoprotective activity from Centaurium spicatum L. |
| title_full_unstemmed | New secoiridoid ester of swertiamarin and secoxyloganic acid with hepatoprotective activity from Centaurium spicatum L. |
| title_short | New secoiridoid ester of swertiamarin and secoxyloganic acid with hepatoprotective activity from Centaurium spicatum L. |
| title_sort | new secoiridoid ester of swertiamarin and secoxyloganic acid with hepatoprotective activity from centaurium spicatum l |
| topic | Centaurium spicatum ester of swertiamarin and secoxyloganic acid hepatoprotective activity NMR analysis |
| url | http://jppres.com/jppres/pdf/vol3/jppres15.058_3.3.69.pdf |
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