Pancreatic cancer and exosomes: role in progression, diagnosis, monitoring, and treatment
Pancreatic cancer (PC) is one of the most dangerous diseases that threaten human life, and investigating the details affecting its progression or regression is particularly important. Exosomes are one of the derivatives produced from different cells, including tumor cells and other cells such as Tre...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1149551/full |
| _version_ | 1797821981619388416 |
|---|---|
| author | Xingliang Fang Huanrong Lan Ketao Jin Jun Qian |
| author_facet | Xingliang Fang Huanrong Lan Ketao Jin Jun Qian |
| author_sort | Xingliang Fang |
| collection | DOAJ |
| description | Pancreatic cancer (PC) is one of the most dangerous diseases that threaten human life, and investigating the details affecting its progression or regression is particularly important. Exosomes are one of the derivatives produced from different cells, including tumor cells and other cells such as Tregs, M2 macrophages, and MDSCs, and can help tumor growth. These exosomes perform their actions by affecting the cells in the tumor microenvironment, such as pancreatic stellate cells (PSCs) that produce extracellular matrix (ECM) components and immune cells that are responsible for killing tumor cells. It has also been shown that pancreatic cancer cell (PCC)-derived exosomes at different stages carry molecules. Checking the presence of these molecules in the blood and other body fluids can help us in the early stage diagnosis and monitoring of PC. However, immune system cell-derived exosomes (IEXs) and mesenchymal stem cell (MSC)-derived exosomes can contribute to PC treatment. Immune cells produce exosomes as part of the mechanisms involved in the immune surveillance and tumor cell-killing phenomenon. Exosomes can be modified in such a way that their antitumor properties are enhanced. One of these methods is drug loading in exosomes, which can significantly increase the effectiveness of chemotherapy drugs. In general, exosomes form a complex intercellular communication network that plays a role in developing, progressing, diagnosing, monitoring, and treating pancreatic cancer. |
| first_indexed | 2024-03-13T10:01:06Z |
| format | Article |
| id | doaj.art-4c86d14bf41d4d73a826ce287b3a2650 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T10:01:06Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4c86d14bf41d4d73a826ce287b3a26502023-05-23T05:17:54ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-05-011310.3389/fonc.2023.11495511149551Pancreatic cancer and exosomes: role in progression, diagnosis, monitoring, and treatmentXingliang Fang0Huanrong Lan1Ketao Jin2Jun Qian3Department of Hepatobiliary Surgery, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, ChinaDepartment of Surgical Oncology, Hangzhou Cancer Hospital, Hangzhou, Zhejiang, ChinaDepartment of Colorectal Surgery, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, ChinaDepartment of Colorectal Surgery, Xinchang People’s Hospital, Affiliated Xinchang Hospital, Wenzhou Medical University, Xinchang, Zhejiang, ChinaPancreatic cancer (PC) is one of the most dangerous diseases that threaten human life, and investigating the details affecting its progression or regression is particularly important. Exosomes are one of the derivatives produced from different cells, including tumor cells and other cells such as Tregs, M2 macrophages, and MDSCs, and can help tumor growth. These exosomes perform their actions by affecting the cells in the tumor microenvironment, such as pancreatic stellate cells (PSCs) that produce extracellular matrix (ECM) components and immune cells that are responsible for killing tumor cells. It has also been shown that pancreatic cancer cell (PCC)-derived exosomes at different stages carry molecules. Checking the presence of these molecules in the blood and other body fluids can help us in the early stage diagnosis and monitoring of PC. However, immune system cell-derived exosomes (IEXs) and mesenchymal stem cell (MSC)-derived exosomes can contribute to PC treatment. Immune cells produce exosomes as part of the mechanisms involved in the immune surveillance and tumor cell-killing phenomenon. Exosomes can be modified in such a way that their antitumor properties are enhanced. One of these methods is drug loading in exosomes, which can significantly increase the effectiveness of chemotherapy drugs. In general, exosomes form a complex intercellular communication network that plays a role in developing, progressing, diagnosing, monitoring, and treating pancreatic cancer.https://www.frontiersin.org/articles/10.3389/fonc.2023.1149551/fullpancreatic cancerexosomediagnosisprognosistumortreatment |
| spellingShingle | Xingliang Fang Huanrong Lan Ketao Jin Jun Qian Pancreatic cancer and exosomes: role in progression, diagnosis, monitoring, and treatment Frontiers in Oncology pancreatic cancer exosome diagnosis prognosis tumor treatment |
| title | Pancreatic cancer and exosomes: role in progression, diagnosis, monitoring, and treatment |
| title_full | Pancreatic cancer and exosomes: role in progression, diagnosis, monitoring, and treatment |
| title_fullStr | Pancreatic cancer and exosomes: role in progression, diagnosis, monitoring, and treatment |
| title_full_unstemmed | Pancreatic cancer and exosomes: role in progression, diagnosis, monitoring, and treatment |
| title_short | Pancreatic cancer and exosomes: role in progression, diagnosis, monitoring, and treatment |
| title_sort | pancreatic cancer and exosomes role in progression diagnosis monitoring and treatment |
| topic | pancreatic cancer exosome diagnosis prognosis tumor treatment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1149551/full |
| work_keys_str_mv | AT xingliangfang pancreaticcancerandexosomesroleinprogressiondiagnosismonitoringandtreatment AT huanronglan pancreaticcancerandexosomesroleinprogressiondiagnosismonitoringandtreatment AT ketaojin pancreaticcancerandexosomesroleinprogressiondiagnosismonitoringandtreatment AT junqian pancreaticcancerandexosomesroleinprogressiondiagnosismonitoringandtreatment |