Research progress on OX40/OX40L axis mediated T cell immunity in the course of oral lichen planus
Oral lichen planus (OLP) is a common chronic disease of the oral mucosa with unclear pathogenesis. Local infiltration of T cells plays a key role in the pathological process of OLP. Increased evidence supports the notion that the imbalance of helper T cells (Th) 1/Th2 and Th17/regulatory T cells (Tr...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
2022-07-01
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| Series: | 口腔疾病防治 |
| Subjects: | |
| Online Access: | http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2022.07.010 |
| _version_ | 1811303672228872192 |
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| author | LIU Yang WANG Xing ZHANG Ni ZHANG Fang |
| author_facet | LIU Yang WANG Xing ZHANG Ni ZHANG Fang |
| author_sort | LIU Yang |
| collection | DOAJ |
| description | Oral lichen planus (OLP) is a common chronic disease of the oral mucosa with unclear pathogenesis. Local infiltration of T cells plays a key role in the pathological process of OLP. Increased evidence supports the notion that the imbalance of helper T cells (Th) 1/Th2 and Th17/regulatory T cells (Treg) and their related cytokines is closely related to the pathogenesis and progression of OLP. In recent years, studies have shown that OX40 (CD134) and its ligand OX40L (CD252) play an important role in the process of the T-cell immune response. They participate in the balance regulation of Th1/Th2 and Th17/Treg, mediate the imbalance of pro-inflammatory and anti-inflammatory, and affect the occurrence and development of a variety of autoimmune diseases. However, there is no direct evidence that the OX40/OX40L axis mediates the imbalance of T-cell subsets in the pathogenesis of OLP. Therefore, large sample clinical as well as in vitro and in vivo experimental studies on the mechanism by which the OX40/OX40L axis regulates the balance of T-cell subsets in OLP are still needed in the future. |
| first_indexed | 2024-04-13T07:52:18Z |
| format | Article |
| id | doaj.art-4c89015637e2455b9f90090d3aaed80b |
| institution | Directory Open Access Journal |
| issn | 2096-1456 |
| language | zho |
| last_indexed | 2024-04-13T07:52:18Z |
| publishDate | 2022-07-01 |
| publisher | Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases |
| record_format | Article |
| series | 口腔疾病防治 |
| spelling | doaj.art-4c89015637e2455b9f90090d3aaed80b2022-12-22T02:55:30ZzhoEditorial Department of Journal of Prevention and Treatment for Stomatological Diseases口腔疾病防治2096-14562022-07-0130752352710.12016/j.issn.2096-1456.2022.07.010Research progress on OX40/OX40L axis mediated T cell immunity in the course of oral lichen planusLIU Yang0WANG Xing1ZHANG Ni2ZHANG Fang3Shanxi Medical University School and Hospital of StomatologyShanxi Medical University School and Hospital of StomatologyShanxi Medical University School and Hospital of StomatologyShanxi Medical University School and Hospital of StomatologyOral lichen planus (OLP) is a common chronic disease of the oral mucosa with unclear pathogenesis. Local infiltration of T cells plays a key role in the pathological process of OLP. Increased evidence supports the notion that the imbalance of helper T cells (Th) 1/Th2 and Th17/regulatory T cells (Treg) and their related cytokines is closely related to the pathogenesis and progression of OLP. In recent years, studies have shown that OX40 (CD134) and its ligand OX40L (CD252) play an important role in the process of the T-cell immune response. They participate in the balance regulation of Th1/Th2 and Th17/Treg, mediate the imbalance of pro-inflammatory and anti-inflammatory, and affect the occurrence and development of a variety of autoimmune diseases. However, there is no direct evidence that the OX40/OX40L axis mediates the imbalance of T-cell subsets in the pathogenesis of OLP. Therefore, large sample clinical as well as in vitro and in vivo experimental studies on the mechanism by which the OX40/OX40L axis regulates the balance of T-cell subsets in OLP are still needed in the future.http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2022.07.010helper t cells，costimulatory molecules，ox40/ox40l，oral lichen planus，immunological mechanism，cytokines，t cell subsets，immunotherapy，targeted therapy， |
| spellingShingle | LIU Yang WANG Xing ZHANG Ni ZHANG Fang Research progress on OX40/OX40L axis mediated T cell immunity in the course of oral lichen planus 口腔疾病防治 helper t cells， costimulatory molecules， ox40/ox40l， oral lichen planus， immunological mechanism， cytokines， t cell subsets， immunotherapy， targeted therapy， |
| title | Research progress on OX40/OX40L axis mediated T cell immunity in the course of oral lichen planus |
| title_full | Research progress on OX40/OX40L axis mediated T cell immunity in the course of oral lichen planus |
| title_fullStr | Research progress on OX40/OX40L axis mediated T cell immunity in the course of oral lichen planus |
| title_full_unstemmed | Research progress on OX40/OX40L axis mediated T cell immunity in the course of oral lichen planus |
| title_short | Research progress on OX40/OX40L axis mediated T cell immunity in the course of oral lichen planus |
| title_sort | research progress on ox40 ox40l axis mediated t cell immunity in the course of oral lichen planus |
| topic | helper t cells， costimulatory molecules， ox40/ox40l， oral lichen planus， immunological mechanism， cytokines， t cell subsets， immunotherapy， targeted therapy， |
| url | http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2022.07.010 |
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