Evidence of a role for the lateral hypothalamic area juxtadorsomedial region (LHAjd) in defensive behaviors associated with social defeat.
Our understanding of the extrinsic connections of the lateral hypothalamic area (LHA) has deepened in recent years. In particular, a series of studies using neural pathway-tracing methods to investigate the macroconnections of histologically differentiated LHA regions, have revealed that the neural...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-11-01
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| Series: | Frontiers in Systems Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsys.2016.00092/full |
| _version_ | 1818893512702164992 |
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| author | Miguel J Rangel Marcus V C Baldo Newton Sabino Canteras Joel D Hahn |
| author_facet | Miguel J Rangel Marcus V C Baldo Newton Sabino Canteras Joel D Hahn |
| author_sort | Miguel J Rangel |
| collection | DOAJ |
| description | Our understanding of the extrinsic connections of the lateral hypothalamic area (LHA) has deepened in recent years. In particular, a series of studies using neural pathway-tracing methods to investigate the macroconnections of histologically differentiated LHA regions, have revealed that the neural connections of these regions are substantially distinct, and have robust connections with neural circuits controlling survival behaviors. To begin testing functional associations suggested by the distinct LHA region neural connections, the present study has investigated the role of the LHA juxtadorsomedial region (LHAjd) in the control of social defeat (a socially-relevant defensive behavior). Male rats received bilateral cytotoxic lesions targeted to the LHAjd. A resident-intruder paradigm was then employed to investigate the effect of these lesions on defensive behavioral responses. Behavioral data were collected during three phases of testing: 1) pre-encounter habituation to testing context, 2) encounter with a dominant conspecific in the testing context, and 3) post-encounter context. Statistical analysis of behavioral measures revealed a significant decrease in risk assessment behaviors during post-encounter context testing in lesioned intruders compared to sham-lesioned and intact rats. However, changes in defensive behavioral measures during the habituation, or during resident-intruder encounters, did not reach significance. We discuss these data in relation to LHAjd (and neighboring LHA region) neural connections, and in relation to current advances in understanding of the neural control of defensive behaviors. A refined model for the neural circuits that are central to the control of socially-relevant defensive behaviors is outlined. We also consider possible broader implications of these data for disorders of behavioral control. |
| first_indexed | 2024-12-19T18:13:47Z |
| format | Article |
| id | doaj.art-4c89376bc9354d3e9ee371f5dd873246 |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-12-19T18:13:47Z |
| publishDate | 2016-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-4c89376bc9354d3e9ee371f5dd8732462022-12-21T20:11:12ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372016-11-011010.3389/fnsys.2016.00092224225Evidence of a role for the lateral hypothalamic area juxtadorsomedial region (LHAjd) in defensive behaviors associated with social defeat.Miguel J Rangel0Marcus V C Baldo1Newton Sabino Canteras2Joel D Hahn3University of São PauloUniversity of São PauloUniversity of São PauloUniversity of Southern CaliforniaOur understanding of the extrinsic connections of the lateral hypothalamic area (LHA) has deepened in recent years. In particular, a series of studies using neural pathway-tracing methods to investigate the macroconnections of histologically differentiated LHA regions, have revealed that the neural connections of these regions are substantially distinct, and have robust connections with neural circuits controlling survival behaviors. To begin testing functional associations suggested by the distinct LHA region neural connections, the present study has investigated the role of the LHA juxtadorsomedial region (LHAjd) in the control of social defeat (a socially-relevant defensive behavior). Male rats received bilateral cytotoxic lesions targeted to the LHAjd. A resident-intruder paradigm was then employed to investigate the effect of these lesions on defensive behavioral responses. Behavioral data were collected during three phases of testing: 1) pre-encounter habituation to testing context, 2) encounter with a dominant conspecific in the testing context, and 3) post-encounter context. Statistical analysis of behavioral measures revealed a significant decrease in risk assessment behaviors during post-encounter context testing in lesioned intruders compared to sham-lesioned and intact rats. However, changes in defensive behavioral measures during the habituation, or during resident-intruder encounters, did not reach significance. We discuss these data in relation to LHAjd (and neighboring LHA region) neural connections, and in relation to current advances in understanding of the neural control of defensive behaviors. A refined model for the neural circuits that are central to the control of socially-relevant defensive behaviors is outlined. We also consider possible broader implications of these data for disorders of behavioral control.http://journal.frontiersin.org/Journal/10.3389/fnsys.2016.00092/fullBehavior, AnimalHypothalamusSocial Defeatlateral hypothalamic areaLHAjd |
| spellingShingle | Miguel J Rangel Marcus V C Baldo Newton Sabino Canteras Joel D Hahn Evidence of a role for the lateral hypothalamic area juxtadorsomedial region (LHAjd) in defensive behaviors associated with social defeat. Frontiers in Systems Neuroscience Behavior, Animal Hypothalamus Social Defeat lateral hypothalamic area LHAjd |
| title | Evidence of a role for the lateral hypothalamic area juxtadorsomedial region (LHAjd) in defensive behaviors associated with social defeat. |
| title_full | Evidence of a role for the lateral hypothalamic area juxtadorsomedial region (LHAjd) in defensive behaviors associated with social defeat. |
| title_fullStr | Evidence of a role for the lateral hypothalamic area juxtadorsomedial region (LHAjd) in defensive behaviors associated with social defeat. |
| title_full_unstemmed | Evidence of a role for the lateral hypothalamic area juxtadorsomedial region (LHAjd) in defensive behaviors associated with social defeat. |
| title_short | Evidence of a role for the lateral hypothalamic area juxtadorsomedial region (LHAjd) in defensive behaviors associated with social defeat. |
| title_sort | evidence of a role for the lateral hypothalamic area juxtadorsomedial region lhajd in defensive behaviors associated with social defeat |
| topic | Behavior, Animal Hypothalamus Social Defeat lateral hypothalamic area LHAjd |
| url | http://journal.frontiersin.org/Journal/10.3389/fnsys.2016.00092/full |
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