Changes in the Brain Metabolism Associated with Central Post-Stroke Pain in Hemorrhagic Pontine Stroke: An <sup>18</sup>F-FDG-PET Study of the Brain

Central post-stroke pain (CPSP) is an intractable neuropathic pain that can occur following central nervous system injuries. Spino-thalamo-cortical pathway damage contributes to CPSP development. However, brain regions involved in CPSP are unknown and previous studies were limited to supratentorial...

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Main Authors: Soo-jin Choi, Na-young Kim, Jun-yup Kim, Young-sil An, Yong-wook Kim
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Brain Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3425/12/7/837
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author Soo-jin Choi
Na-young Kim
Jun-yup Kim
Young-sil An
Yong-wook Kim
author_facet Soo-jin Choi
Na-young Kim
Jun-yup Kim
Young-sil An
Yong-wook Kim
author_sort Soo-jin Choi
collection DOAJ
description Central post-stroke pain (CPSP) is an intractable neuropathic pain that can occur following central nervous system injuries. Spino-thalamo-cortical pathway damage contributes to CPSP development. However, brain regions involved in CPSP are unknown and previous studies were limited to supratentorial strokes with cortical lesion involvement. We analyzed the brain metabolism changes associated with CPSP following pontine hemorrhage. Thirty-two patients with isolated pontine hemorrhage were examined; 14 had CPSP, while 18 did not. Brain glucose metabolism was evaluated using <sup>18</sup>F-fluorodeoxyglucose-positron emission tomography images. Additionally, regions revealing metabolic correlation with CPSP severity were analyzed. Patients with CPSP showed changes in the brain metabolism in the cerebral cortices and cerebellum. Compared with the control group, the CPSP group showed significant hypometabolism in the contralesional rostral anterior cingulum and ipsilesional primary motor cortex (<i>P<sub>uncorrected</sub></i> < 0.001). However, increased brain metabolism was observed in the ipsilesional cerebellum (VI) and contralesional cerebellum (lobule VIIB) (<i>P<sub>uncorrected</sub></i> < 0.001). Moreover, increased pain intensity correlated with decreased metabolism in the ipsilesional supplementary motor area and contralesional angular gyrus. This study emphasizes the role of the many different areas of the cortex that are involved in affective and cognitive processing in the development of CPSP.
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spelling doaj.art-4c8a8a24ea39445db2a184ed68b964db2023-12-03T14:44:49ZengMDPI AGBrain Sciences2076-34252022-06-0112783710.3390/brainsci12070837Changes in the Brain Metabolism Associated with Central Post-Stroke Pain in Hemorrhagic Pontine Stroke: An <sup>18</sup>F-FDG-PET Study of the BrainSoo-jin Choi0Na-young Kim1Jun-yup Kim2Young-sil An3Yong-wook Kim4Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, KoreaDepartment and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, KoreaDepartment of Physical Medicine and Rehabilitation, Hanyang University Medical Center, Seoul 04763, KoreaDepartment of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, Suwon 16499, KoreaDepartment and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, KoreaCentral post-stroke pain (CPSP) is an intractable neuropathic pain that can occur following central nervous system injuries. Spino-thalamo-cortical pathway damage contributes to CPSP development. However, brain regions involved in CPSP are unknown and previous studies were limited to supratentorial strokes with cortical lesion involvement. We analyzed the brain metabolism changes associated with CPSP following pontine hemorrhage. Thirty-two patients with isolated pontine hemorrhage were examined; 14 had CPSP, while 18 did not. Brain glucose metabolism was evaluated using <sup>18</sup>F-fluorodeoxyglucose-positron emission tomography images. Additionally, regions revealing metabolic correlation with CPSP severity were analyzed. Patients with CPSP showed changes in the brain metabolism in the cerebral cortices and cerebellum. Compared with the control group, the CPSP group showed significant hypometabolism in the contralesional rostral anterior cingulum and ipsilesional primary motor cortex (<i>P<sub>uncorrected</sub></i> < 0.001). However, increased brain metabolism was observed in the ipsilesional cerebellum (VI) and contralesional cerebellum (lobule VIIB) (<i>P<sub>uncorrected</sub></i> < 0.001). Moreover, increased pain intensity correlated with decreased metabolism in the ipsilesional supplementary motor area and contralesional angular gyrus. This study emphasizes the role of the many different areas of the cortex that are involved in affective and cognitive processing in the development of CPSP.https://www.mdpi.com/2076-3425/12/7/837painponsstrokecerebral hemorrhagecerebral cortexcerebellum
spellingShingle Soo-jin Choi
Na-young Kim
Jun-yup Kim
Young-sil An
Yong-wook Kim
Changes in the Brain Metabolism Associated with Central Post-Stroke Pain in Hemorrhagic Pontine Stroke: An <sup>18</sup>F-FDG-PET Study of the Brain
Brain Sciences
pain
pons
stroke
cerebral hemorrhage
cerebral cortex
cerebellum
title Changes in the Brain Metabolism Associated with Central Post-Stroke Pain in Hemorrhagic Pontine Stroke: An <sup>18</sup>F-FDG-PET Study of the Brain
title_full Changes in the Brain Metabolism Associated with Central Post-Stroke Pain in Hemorrhagic Pontine Stroke: An <sup>18</sup>F-FDG-PET Study of the Brain
title_fullStr Changes in the Brain Metabolism Associated with Central Post-Stroke Pain in Hemorrhagic Pontine Stroke: An <sup>18</sup>F-FDG-PET Study of the Brain
title_full_unstemmed Changes in the Brain Metabolism Associated with Central Post-Stroke Pain in Hemorrhagic Pontine Stroke: An <sup>18</sup>F-FDG-PET Study of the Brain
title_short Changes in the Brain Metabolism Associated with Central Post-Stroke Pain in Hemorrhagic Pontine Stroke: An <sup>18</sup>F-FDG-PET Study of the Brain
title_sort changes in the brain metabolism associated with central post stroke pain in hemorrhagic pontine stroke an sup 18 sup f fdg pet study of the brain
topic pain
pons
stroke
cerebral hemorrhage
cerebral cortex
cerebellum
url https://www.mdpi.com/2076-3425/12/7/837
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