Association between brain imaging biomarkers and continuous glucose monitoring-derived glycemic control indices in Japanese patients with type 2 diabetes mellitus
Introduction Although type 2 diabetes mellitus (T2DM) is associated with alterations in brain structure, the relationship between glycemic control indices and brain imaging markers remains unclear. This study aimed to investigate the association between continuous glucose monitoring (CGM)-derived gl...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2024-02-01
|
| Series: | BMJ Open Diabetes Research & Care |
| Online Access: | https://drc.bmj.com/content/12/1/e003744.full |
| _version_ | 1797289388430852096 |
|---|---|
| author | Akinori Kanzaki Akihito Otsuka Hiroki Ikeda Hiroyuki Konya Manabu Kadoya Satoru Katayama Hidenori Koyama Chikako Inoue Yoshiki Kusunoki Mana Ohigashi Keiko Osugi Kazuhiro Kitajima Ayako Takagi Maki Inoue Chisako Yagi Taku Tsunoda Miki Kakutani Kosuke Konishi Tomoyuki Katsuno Akiko Morimoto Takuhito Shoji Toshihiro Matsuo Hideki Ifuku Daisuke Azuma Takeshi Fukui Isao Hayashi Masataka Kanyama Masaru Usami Tadahiro Inagaki Tomoya Hamaguchi Shogo Kurebayashi Kenji Kusunoki Minoru Kubota Takeharu Sasaki Sachie Hirose Satoshi Matsutani Shinya Makino Tetsuhiro Kitamura Daisuke Tamada Hidenori Taniguchi Nobuaki Watanabe Mitsuyoshi Namba |
| author_facet | Akinori Kanzaki Akihito Otsuka Hiroki Ikeda Hiroyuki Konya Manabu Kadoya Satoru Katayama Hidenori Koyama Chikako Inoue Yoshiki Kusunoki Mana Ohigashi Keiko Osugi Kazuhiro Kitajima Ayako Takagi Maki Inoue Chisako Yagi Taku Tsunoda Miki Kakutani Kosuke Konishi Tomoyuki Katsuno Akiko Morimoto Takuhito Shoji Toshihiro Matsuo Hideki Ifuku Daisuke Azuma Takeshi Fukui Isao Hayashi Masataka Kanyama Masaru Usami Tadahiro Inagaki Tomoya Hamaguchi Shogo Kurebayashi Kenji Kusunoki Minoru Kubota Takeharu Sasaki Sachie Hirose Satoshi Matsutani Shinya Makino Tetsuhiro Kitamura Daisuke Tamada Hidenori Taniguchi Nobuaki Watanabe Mitsuyoshi Namba |
| collection | DOAJ |
| description | Introduction Although type 2 diabetes mellitus (T2DM) is associated with alterations in brain structure, the relationship between glycemic control indices and brain imaging markers remains unclear. This study aimed to investigate the association between continuous glucose monitoring (CGM)-derived glycemic control indices and brain imaging biomarkers assessed by MRI.Research design and methods This cross-sectional study included 150 patients with T2DM. The severity of cerebral white matter lesions (WMLs) was assessed using MRI for deep and subcortical white matter and periventricular hyperintensities. The degree of medial temporal lobe atrophy (MTA) was assessed using voxel-based morphometry. Each participant wore a retrospective CGM for 14 consecutive days, and glycemic control indices, such as time in range (TIR) and glycemia risk index (GRI), were calculated.Results The proportion of patients with severe WMLs showed a decreasing trend with increasing TIR (P for trend=0.006). The proportion of patients with severe WMLs showed an increasing trend with worsening GRI (P for trend=0.011). In contrast, no significant association was observed between the degree of MTA and CGM-derived glycemic control indices, including TIR (P for trend=0.325) and GRI (P for trend=0.447).Conclusions The findings of this study indicate that the severity of WMLs is associated with TIR and GRI, which are indices of the quality of glycemic control.Trial registration number UMIN000032143. |
| first_indexed | 2024-03-07T19:04:14Z |
| format | Article |
| id | doaj.art-4c8b791d22d34ad286bffd4cdcd3695d |
| institution | Directory Open Access Journal |
| issn | 2052-4897 |
| language | English |
| last_indexed | 2024-03-07T19:04:14Z |
| publishDate | 2024-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Diabetes Research & Care |
| spelling | doaj.art-4c8b791d22d34ad286bffd4cdcd3695d2024-03-01T09:35:06ZengBMJ Publishing GroupBMJ Open Diabetes Research & Care2052-48972024-02-0112110.1136/bmjdrc-2023-003744Association between brain imaging biomarkers and continuous glucose monitoring-derived glycemic control indices in Japanese patients with type 2 diabetes mellitus Akinori KanzakiAkihito OtsukaHiroki IkedaHiroyuki KonyaManabu Kadoya0Satoru KatayamaHidenori Koyama1Chikako Inoue2Yoshiki Kusunoki3Mana Ohigashi4Keiko Osugi5Kazuhiro Kitajima6Ayako Takagi7Maki Inoue8Chisako Yagi9Taku Tsunoda10Miki Kakutani11Kosuke Konishi12Tomoyuki Katsuno13Akiko MorimotoTakuhito ShojiToshihiro MatsuoHideki IfukuDaisuke AzumaTakeshi FukuiIsao HayashiMasataka KanyamaMasaru UsamiTadahiro InagakiTomoya HamaguchiShogo KurebayashiKenji KusunokiMinoru KubotaTakeharu SasakiSachie HiroseSatoshi MatsutaniShinya MakinoTetsuhiro KitamuraDaisuke TamadaHidenori TaniguchiNobuaki WatanabeMitsuyoshi NambaDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, JapanDepartment of Radiology, School of Medicine, Hyogo Medical University, Nishinomiya, JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, JapanIntroduction Although type 2 diabetes mellitus (T2DM) is associated with alterations in brain structure, the relationship between glycemic control indices and brain imaging markers remains unclear. This study aimed to investigate the association between continuous glucose monitoring (CGM)-derived glycemic control indices and brain imaging biomarkers assessed by MRI.Research design and methods This cross-sectional study included 150 patients with T2DM. The severity of cerebral white matter lesions (WMLs) was assessed using MRI for deep and subcortical white matter and periventricular hyperintensities. The degree of medial temporal lobe atrophy (MTA) was assessed using voxel-based morphometry. Each participant wore a retrospective CGM for 14 consecutive days, and glycemic control indices, such as time in range (TIR) and glycemia risk index (GRI), were calculated.Results The proportion of patients with severe WMLs showed a decreasing trend with increasing TIR (P for trend=0.006). The proportion of patients with severe WMLs showed an increasing trend with worsening GRI (P for trend=0.011). In contrast, no significant association was observed between the degree of MTA and CGM-derived glycemic control indices, including TIR (P for trend=0.325) and GRI (P for trend=0.447).Conclusions The findings of this study indicate that the severity of WMLs is associated with TIR and GRI, which are indices of the quality of glycemic control.Trial registration number UMIN000032143.https://drc.bmj.com/content/12/1/e003744.full |
| spellingShingle | Akinori Kanzaki Akihito Otsuka Hiroki Ikeda Hiroyuki Konya Manabu Kadoya Satoru Katayama Hidenori Koyama Chikako Inoue Yoshiki Kusunoki Mana Ohigashi Keiko Osugi Kazuhiro Kitajima Ayako Takagi Maki Inoue Chisako Yagi Taku Tsunoda Miki Kakutani Kosuke Konishi Tomoyuki Katsuno Akiko Morimoto Takuhito Shoji Toshihiro Matsuo Hideki Ifuku Daisuke Azuma Takeshi Fukui Isao Hayashi Masataka Kanyama Masaru Usami Tadahiro Inagaki Tomoya Hamaguchi Shogo Kurebayashi Kenji Kusunoki Minoru Kubota Takeharu Sasaki Sachie Hirose Satoshi Matsutani Shinya Makino Tetsuhiro Kitamura Daisuke Tamada Hidenori Taniguchi Nobuaki Watanabe Mitsuyoshi Namba Association between brain imaging biomarkers and continuous glucose monitoring-derived glycemic control indices in Japanese patients with type 2 diabetes mellitus BMJ Open Diabetes Research & Care |
| title | Association between brain imaging biomarkers and continuous glucose monitoring-derived glycemic control indices in Japanese patients with type 2 diabetes mellitus |
| title_full | Association between brain imaging biomarkers and continuous glucose monitoring-derived glycemic control indices in Japanese patients with type 2 diabetes mellitus |
| title_fullStr | Association between brain imaging biomarkers and continuous glucose monitoring-derived glycemic control indices in Japanese patients with type 2 diabetes mellitus |
| title_full_unstemmed | Association between brain imaging biomarkers and continuous glucose monitoring-derived glycemic control indices in Japanese patients with type 2 diabetes mellitus |
| title_short | Association between brain imaging biomarkers and continuous glucose monitoring-derived glycemic control indices in Japanese patients with type 2 diabetes mellitus |
| title_sort | association between brain imaging biomarkers and continuous glucose monitoring derived glycemic control indices in japanese patients with type 2 diabetes mellitus |
| url | https://drc.bmj.com/content/12/1/e003744.full |
| work_keys_str_mv | AT associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT akinorikanzaki associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT akihitootsuka associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT hirokiikeda associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT hiroyukikonya associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT manabukadoya associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT satorukatayama associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT hidenorikoyama associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT chikakoinoue associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT yoshikikusunoki associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT manaohigashi associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT keikoosugi associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT kazuhirokitajima associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT ayakotakagi associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT makiinoue associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT chisakoyagi associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT takutsunoda associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT mikikakutani associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT kosukekonishi associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT tomoyukikatsuno associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT akikomorimoto associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT takuhitoshoji associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT toshihiromatsuo associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT hidekiifuku associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT daisukeazuma associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT takeshifukui associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT isaohayashi associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT masatakakanyama associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT masaruusami associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT tadahiroinagaki associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT tomoyahamaguchi associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT shogokurebayashi associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT kenjikusunoki associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT minorukubota associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT takeharusasaki associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT sachiehirose associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT satoshimatsutani associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT shinyamakino associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT tetsuhirokitamura associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT daisuketamada associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT hidenoritaniguchi associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT nobuakiwatanabe associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus AT mitsuyoshinamba associationbetweenbrainimagingbiomarkersandcontinuousglucosemonitoringderivedglycemiccontrolindicesinjapanesepatientswithtype2diabetesmellitus |