Use of Phentolamine Mesylate in Implant Surgery: Analysis of Adverse Effects and Haemodynamic Changes
The clinical application of phentolamine mesylate (PM) as an anaesthetic reversal agent has been documented in the paediatric population and in conservative dentistry, but no studies have been conducted regarding dental implant surgery. A prospective randomised study was conducted on 60 patients eli...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/17/3875 |
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| author | Clara Vintanel-Moreno José María Martínez-González Natalia Martínez-Rodríguez Cristina Meniz-García Isabel Leco-Berrocal |
| author_facet | Clara Vintanel-Moreno José María Martínez-González Natalia Martínez-Rodríguez Cristina Meniz-García Isabel Leco-Berrocal |
| author_sort | Clara Vintanel-Moreno |
| collection | DOAJ |
| description | The clinical application of phentolamine mesylate (PM) as an anaesthetic reversal agent has been documented in the paediatric population and in conservative dentistry, but no studies have been conducted regarding dental implant surgery. A prospective randomised study was conducted on 60 patients eligible for mandibular implant treatment, randomly divided between a control group (CG) and an experimental group (EG), to whom PM was administered. Haemodynamic changes, adverse effects and patient satisfaction were assessed. No statistically significant differences in haemodynamic changes and postoperative pain were found between CG and EG (<i>p</i> < 0.05), except for systolic blood pressure (SBP), which increased slightly in EG, without posing a risk to patients. There were no differences in the occurrence of adverse effects between the two groups, except for greater difficulty in chewing and biting (<i>p</i> < 0.05) in CG and greater pain in the injection area (<i>p</i> = 0.043) in EG. Among EG patients, 83.3% reported that they would request PM again for future dental treatment. The use of PM offers an alternative to implant surgery, thereby increasing patients’ quality of life without increasing the risks. |
| first_indexed | 2024-03-10T08:09:41Z |
| format | Article |
| id | doaj.art-4c8d61e7b6164a3faf32baf25cc75275 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T08:09:41Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-4c8d61e7b6164a3faf32baf25cc752752023-11-22T10:48:42ZengMDPI AGJournal of Clinical Medicine2077-03832021-08-011017387510.3390/jcm10173875Use of Phentolamine Mesylate in Implant Surgery: Analysis of Adverse Effects and Haemodynamic ChangesClara Vintanel-Moreno0José María Martínez-González1Natalia Martínez-Rodríguez2Cristina Meniz-García3Isabel Leco-Berrocal4Department of Dental Clinical Specialties, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Dental Clinical Specialties, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Dental Clinical Specialties, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Dental Clinical Specialties, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Dental Clinical Specialties, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, SpainThe clinical application of phentolamine mesylate (PM) as an anaesthetic reversal agent has been documented in the paediatric population and in conservative dentistry, but no studies have been conducted regarding dental implant surgery. A prospective randomised study was conducted on 60 patients eligible for mandibular implant treatment, randomly divided between a control group (CG) and an experimental group (EG), to whom PM was administered. Haemodynamic changes, adverse effects and patient satisfaction were assessed. No statistically significant differences in haemodynamic changes and postoperative pain were found between CG and EG (<i>p</i> < 0.05), except for systolic blood pressure (SBP), which increased slightly in EG, without posing a risk to patients. There were no differences in the occurrence of adverse effects between the two groups, except for greater difficulty in chewing and biting (<i>p</i> < 0.05) in CG and greater pain in the injection area (<i>p</i> = 0.043) in EG. Among EG patients, 83.3% reported that they would request PM again for future dental treatment. The use of PM offers an alternative to implant surgery, thereby increasing patients’ quality of life without increasing the risks.https://www.mdpi.com/2077-0383/10/17/3875phentolamine mesylatedental implantshaemodynamic changesadverse effectssatisfaction |
| spellingShingle | Clara Vintanel-Moreno José María Martínez-González Natalia Martínez-Rodríguez Cristina Meniz-García Isabel Leco-Berrocal Use of Phentolamine Mesylate in Implant Surgery: Analysis of Adverse Effects and Haemodynamic Changes Journal of Clinical Medicine phentolamine mesylate dental implants haemodynamic changes adverse effects satisfaction |
| title | Use of Phentolamine Mesylate in Implant Surgery: Analysis of Adverse Effects and Haemodynamic Changes |
| title_full | Use of Phentolamine Mesylate in Implant Surgery: Analysis of Adverse Effects and Haemodynamic Changes |
| title_fullStr | Use of Phentolamine Mesylate in Implant Surgery: Analysis of Adverse Effects and Haemodynamic Changes |
| title_full_unstemmed | Use of Phentolamine Mesylate in Implant Surgery: Analysis of Adverse Effects and Haemodynamic Changes |
| title_short | Use of Phentolamine Mesylate in Implant Surgery: Analysis of Adverse Effects and Haemodynamic Changes |
| title_sort | use of phentolamine mesylate in implant surgery analysis of adverse effects and haemodynamic changes |
| topic | phentolamine mesylate dental implants haemodynamic changes adverse effects satisfaction |
| url | https://www.mdpi.com/2077-0383/10/17/3875 |
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