Gut microbiota and tumor-associated macrophages: potential in tumor diagnosis and treatment
ABSTRACTAvoiding immune destruction and polymorphic microbiomes are two key hallmarks of cancer. The tumor microenvironment (TME) is essential for the development of solid tumors, and the function of tumor-associated macrophages (TAMs) in the TME is closely linked to tumor prognosis. Therefore, rese...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2276314 |
| _version_ | 1797320550860718080 |
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| author | Dongqin Zhou Yongsheng Li |
| author_facet | Dongqin Zhou Yongsheng Li |
| author_sort | Dongqin Zhou |
| collection | DOAJ |
| description | ABSTRACTAvoiding immune destruction and polymorphic microbiomes are two key hallmarks of cancer. The tumor microenvironment (TME) is essential for the development of solid tumors, and the function of tumor-associated macrophages (TAMs) in the TME is closely linked to tumor prognosis. Therefore, research on TAMs could improve the progression and control of certain tumor patients. Additionally, the intestinal flora plays a crucial role in metabolizing substances and maintaining a symbiotic relationship with the host through a complex network of interactions. Recent experimental and clinical studies have suggested a potential link between gut microbiome and TME, particularly in regulating TAMs. Understanding this association could improve the efficacy of tumor immunotherapy. This review highlights the regulatory role of intestinal flora on TAMs, with a focus on gut microbiota and their metabolites. The implications of this association for tumor diagnosis and treatment are also discussed, providing a promising avenue for future clinical treatment strategies. |
| first_indexed | 2024-03-08T04:40:47Z |
| format | Article |
| id | doaj.art-4c8efafad4114f44bbbedc265f525d61 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-03-08T04:40:47Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-4c8efafad4114f44bbbedc265f525d612024-02-08T12:02:08ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115210.1080/19490976.2023.2276314Gut microbiota and tumor-associated macrophages: potential in tumor diagnosis and treatmentDongqin Zhou0Yongsheng Li1The Second Affliated Hospital & Yuying Children's Hospital / The Second School of Medicine, Wenzhou Medical University, Wenzhou, ChinaThe Second Affliated Hospital & Yuying Children's Hospital / The Second School of Medicine, Wenzhou Medical University, Wenzhou, ChinaABSTRACTAvoiding immune destruction and polymorphic microbiomes are two key hallmarks of cancer. The tumor microenvironment (TME) is essential for the development of solid tumors, and the function of tumor-associated macrophages (TAMs) in the TME is closely linked to tumor prognosis. Therefore, research on TAMs could improve the progression and control of certain tumor patients. Additionally, the intestinal flora plays a crucial role in metabolizing substances and maintaining a symbiotic relationship with the host through a complex network of interactions. Recent experimental and clinical studies have suggested a potential link between gut microbiome and TME, particularly in regulating TAMs. Understanding this association could improve the efficacy of tumor immunotherapy. This review highlights the regulatory role of intestinal flora on TAMs, with a focus on gut microbiota and their metabolites. The implications of this association for tumor diagnosis and treatment are also discussed, providing a promising avenue for future clinical treatment strategies.https://www.tandfonline.com/doi/10.1080/19490976.2023.2276314Tumor microenvironmentgut microbiotatumor-associated macrophagescancer diagnosisimmunotherapy |
| spellingShingle | Dongqin Zhou Yongsheng Li Gut microbiota and tumor-associated macrophages: potential in tumor diagnosis and treatment Gut Microbes Tumor microenvironment gut microbiota tumor-associated macrophages cancer diagnosis immunotherapy |
| title | Gut microbiota and tumor-associated macrophages: potential in tumor diagnosis and treatment |
| title_full | Gut microbiota and tumor-associated macrophages: potential in tumor diagnosis and treatment |
| title_fullStr | Gut microbiota and tumor-associated macrophages: potential in tumor diagnosis and treatment |
| title_full_unstemmed | Gut microbiota and tumor-associated macrophages: potential in tumor diagnosis and treatment |
| title_short | Gut microbiota and tumor-associated macrophages: potential in tumor diagnosis and treatment |
| title_sort | gut microbiota and tumor associated macrophages potential in tumor diagnosis and treatment |
| topic | Tumor microenvironment gut microbiota tumor-associated macrophages cancer diagnosis immunotherapy |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2276314 |
| work_keys_str_mv | AT dongqinzhou gutmicrobiotaandtumorassociatedmacrophagespotentialintumordiagnosisandtreatment AT yongshengli gutmicrobiotaandtumorassociatedmacrophagespotentialintumordiagnosisandtreatment |