Risk of Vestibulocochlear Disorders in Patients with Migraine or Non-Migraine Headache
Headaches, especially migraines, have been associated with various vestibular symptoms and syndromes. Tinnitus and hearing loss have also been reported to be more prevalent among migraineurs. However, whether headaches, including migraine or non-migraine headaches (nMH), are associated with vestibul...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/12/1331 |
| _version_ | 1797503107293249536 |
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| author | Sang-Hwa Lee Jong-Ho Kim Young-Suk Kwon Jae-June Lee Jong-Hee Sohn |
| author_facet | Sang-Hwa Lee Jong-Ho Kim Young-Suk Kwon Jae-June Lee Jong-Hee Sohn |
| author_sort | Sang-Hwa Lee |
| collection | DOAJ |
| description | Headaches, especially migraines, have been associated with various vestibular symptoms and syndromes. Tinnitus and hearing loss have also been reported to be more prevalent among migraineurs. However, whether headaches, including migraine or non-migraine headaches (nMH), are associated with vestibular and cochlear disorders remains unclear. Thus, we sought to investigate possible associations between headache and vestibulocochlear disorders. We analyzed 10 years of data from the Smart Clinical Data Warehouse. In patients with migraines and nMH, meniere’s disease (MD), BPPV, vestibular neuronitis (VN) and cochlear disorders, such as sensorineural hearing loss (SNHL) and tinnitus, were collected and compared to clinical data from controls who had health check-ups without headache. Participants included 15,128 with migraines, 76,773 patients with nMH and controls were identified based on propensity score matching (PSM). After PSM, the odds ratios (OR) in subjects with migraine versus controls were 2.59 for MD, 2.05 for BPPV, 2.98 for VN, 1.74 for SNHL, and 1.97 for tinnitus, respectively (<i>p</i> < 0.001). The OR for MD (1.77), BPPV (1.73), VN (2.05), SNHL (1.40), and tinnitus (1.70) in patients with nMH was also high after matching (<i>p</i> < 0.001). Our findings suggest that migraines and nMH are associated with an increased risk of cochlear disorders in addition to vestibular disorders. |
| first_indexed | 2024-03-10T03:45:47Z |
| format | Article |
| id | doaj.art-4c8feb59aba549cbac3ce00c669189a2 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T03:45:47Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-4c8feb59aba549cbac3ce00c669189a22023-11-23T09:08:03ZengMDPI AGJournal of Personalized Medicine2075-44262021-12-011112133110.3390/jpm11121331Risk of Vestibulocochlear Disorders in Patients with Migraine or Non-Migraine HeadacheSang-Hwa Lee0Jong-Ho Kim1Young-Suk Kwon2Jae-June Lee3Jong-Hee Sohn4Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24253, KoreaInstitute of New Frontier Research Team, College of Medicine, Hallym University College of Medicine, Chuncheon 24253, KoreaInstitute of New Frontier Research Team, College of Medicine, Hallym University College of Medicine, Chuncheon 24253, KoreaInstitute of New Frontier Research Team, College of Medicine, Hallym University College of Medicine, Chuncheon 24253, KoreaDepartment of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24253, KoreaHeadaches, especially migraines, have been associated with various vestibular symptoms and syndromes. Tinnitus and hearing loss have also been reported to be more prevalent among migraineurs. However, whether headaches, including migraine or non-migraine headaches (nMH), are associated with vestibular and cochlear disorders remains unclear. Thus, we sought to investigate possible associations between headache and vestibulocochlear disorders. We analyzed 10 years of data from the Smart Clinical Data Warehouse. In patients with migraines and nMH, meniere’s disease (MD), BPPV, vestibular neuronitis (VN) and cochlear disorders, such as sensorineural hearing loss (SNHL) and tinnitus, were collected and compared to clinical data from controls who had health check-ups without headache. Participants included 15,128 with migraines, 76,773 patients with nMH and controls were identified based on propensity score matching (PSM). After PSM, the odds ratios (OR) in subjects with migraine versus controls were 2.59 for MD, 2.05 for BPPV, 2.98 for VN, 1.74 for SNHL, and 1.97 for tinnitus, respectively (<i>p</i> < 0.001). The OR for MD (1.77), BPPV (1.73), VN (2.05), SNHL (1.40), and tinnitus (1.70) in patients with nMH was also high after matching (<i>p</i> < 0.001). Our findings suggest that migraines and nMH are associated with an increased risk of cochlear disorders in addition to vestibular disorders.https://www.mdpi.com/2075-4426/11/12/1331migraineheadachevestibular disordercochlear disordertinnitushearing loss |
| spellingShingle | Sang-Hwa Lee Jong-Ho Kim Young-Suk Kwon Jae-June Lee Jong-Hee Sohn Risk of Vestibulocochlear Disorders in Patients with Migraine or Non-Migraine Headache Journal of Personalized Medicine migraine headache vestibular disorder cochlear disorder tinnitus hearing loss |
| title | Risk of Vestibulocochlear Disorders in Patients with Migraine or Non-Migraine Headache |
| title_full | Risk of Vestibulocochlear Disorders in Patients with Migraine or Non-Migraine Headache |
| title_fullStr | Risk of Vestibulocochlear Disorders in Patients with Migraine or Non-Migraine Headache |
| title_full_unstemmed | Risk of Vestibulocochlear Disorders in Patients with Migraine or Non-Migraine Headache |
| title_short | Risk of Vestibulocochlear Disorders in Patients with Migraine or Non-Migraine Headache |
| title_sort | risk of vestibulocochlear disorders in patients with migraine or non migraine headache |
| topic | migraine headache vestibular disorder cochlear disorder tinnitus hearing loss |
| url | https://www.mdpi.com/2075-4426/11/12/1331 |
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