Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells.
The rapidly growing field of targeted tumor therapy often utilizes an antibody, sometimes tagged with a tumor-ablating material such as radioisotope, directed against a specific molecule.This report describes the discovery of nine novel decapeptides which can be radioactively labeled, bind to, and d...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2007-10-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC1978517?pdf=render |
| _version_ | 1817980771228450816 |
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| author | John M Abraham Fumiaki Sato Yulan Cheng Bogdan Paun Takatsugu Kan Alexandru Olaru Zhe Jin Jian Yang Rachana Agarwal Stefan David James P Hamilton Tetsuo Ito Yuriko Mori Stephen J Meltzer |
| author_facet | John M Abraham Fumiaki Sato Yulan Cheng Bogdan Paun Takatsugu Kan Alexandru Olaru Zhe Jin Jian Yang Rachana Agarwal Stefan David James P Hamilton Tetsuo Ito Yuriko Mori Stephen J Meltzer |
| author_sort | John M Abraham |
| collection | DOAJ |
| description | The rapidly growing field of targeted tumor therapy often utilizes an antibody, sometimes tagged with a tumor-ablating material such as radioisotope, directed against a specific molecule.This report describes the discovery of nine novel decapeptides which can be radioactively labeled, bind to, and deliver (32)P to colon cancer cells. The decapeptides vary from one another by one to three amino acids and demonstrate vastly different binding abilities. The most avidly binding decapeptide can permanently deliver very high levels of radioisotope to the adenocarcinoma cancer cell lines at an efficiency 35 to 150 times greater than to a variety of other cell types, including cell lines derived from other types of cancer or from normal tissue.This experimental approach represents a new example of a strategy, termed peptide binding therapy, for the potential treatment of colorectal and other adenocarcinomas. |
| first_indexed | 2024-04-13T22:58:34Z |
| format | Article |
| id | doaj.art-4c9046db201645d584288b2b11f6bfc4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T22:58:34Z |
| publishDate | 2007-10-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4c9046db201645d584288b2b11f6bfc42022-12-22T02:25:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032007-10-01210e96410.1371/journal.pone.0000964Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells.John M AbrahamFumiaki SatoYulan ChengBogdan PaunTakatsugu KanAlexandru OlaruZhe JinJian YangRachana AgarwalStefan DavidJames P HamiltonTetsuo ItoYuriko MoriStephen J MeltzerThe rapidly growing field of targeted tumor therapy often utilizes an antibody, sometimes tagged with a tumor-ablating material such as radioisotope, directed against a specific molecule.This report describes the discovery of nine novel decapeptides which can be radioactively labeled, bind to, and deliver (32)P to colon cancer cells. The decapeptides vary from one another by one to three amino acids and demonstrate vastly different binding abilities. The most avidly binding decapeptide can permanently deliver very high levels of radioisotope to the adenocarcinoma cancer cell lines at an efficiency 35 to 150 times greater than to a variety of other cell types, including cell lines derived from other types of cancer or from normal tissue.This experimental approach represents a new example of a strategy, termed peptide binding therapy, for the potential treatment of colorectal and other adenocarcinomas.http://europepmc.org/articles/PMC1978517?pdf=render |
| spellingShingle | John M Abraham Fumiaki Sato Yulan Cheng Bogdan Paun Takatsugu Kan Alexandru Olaru Zhe Jin Jian Yang Rachana Agarwal Stefan David James P Hamilton Tetsuo Ito Yuriko Mori Stephen J Meltzer Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells. PLoS ONE |
| title | Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells. |
| title_full | Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells. |
| title_fullStr | Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells. |
| title_full_unstemmed | Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells. |
| title_short | Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells. |
| title_sort | novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells |
| url | http://europepmc.org/articles/PMC1978517?pdf=render |
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