The number of osteoclasts in a biopsy specimen can predict the efficacy of neoadjuvant chemotherapy for primary osteosarcoma

The number of osteoclasts in a biopsy specimen can predict the efficacy of neoadjuvant chemotherapy for primary osteosarcoma

Abstract Osteosarcoma is the most common primary malignant bone tumor, and its standard treatment is a combination of surgery and chemotherapy. A poor response to chemotherapy causes unfavorable oncological outcomes. We investigated the correlation between osteoclast differentiation in biopsy specim...

Full description

Bibliographic Details
Main Authors:	Y. Araki, N. Yamamoto, K. Hayashi, A. Takeuchi, S. Miwa, K. Igarashi, T. Higuchi, K. Abe, Y. Taniguchi, H. Yonezawa, S. Morinaga, Y. Asano, H. Ikeda, T. Nojima, H. Tsuchiya
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-01-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-020-80504-w

Similar Items

Author Correction: The number of osteoclasts in a biopsy specimen can predict the efficacy of neoadjuvant chemotherapy for primary osteosarcoma
by: Yoshihiro Araki, et al.
Published: (2021-04-01)

Reconstruction using a frozen autograft for a skull and humeral lesion of synchronous multicentric osteosarcoma after undergoing successful neoadjuvant chemotherapy: a case report and review of the literature
by: Yoshihiro Araki, et al.
Published: (2021-01-01)

Clinical outcomes of frozen autograft reconstruction for the treatment of primary bone sarcoma in adolescents and young adults
by: Yoshihiro Araki, et al.
Published: (2021-08-01)

Diagnosis and treatment of intramedullary osteosclerosis: a report of three cases and literature review
by: Kensaku Abe, et al.
Published: (2020-11-01)

Case Report: Unresectable pulmonary metastases of a giant cell tumor of bone treated with denosumab: a case report and review of literature
by: Shinji Miwa, et al.
Published: (2023-08-01)

Clinical course of grafted cartilage in osteoarticular frozen autografts for reconstruction after resection of malignant bone and soft-tissue tumor involving an epiphysis
by: Katsuhiro Hayashi, et al.
Published: (2020-10-01)

Pedicle frozen autograft–prosthesis composite reconstructions for malignant bone tumors of the proximal femur
by: Gang Xu, et al.
Published: (2020-02-01)

Growth of epiphysis after epiphyseal-preservation surgery for childhood osteosarcoma around the knee joint
by: Akihiko Takeuchi, et al.
Published: (2018-06-01)

Needle tract seeding of a sclerosing epithelioid fibrosarcoma in a biopsy tract: a case report
by: Masafumi Kawai, et al.
Published: (2023-06-01)

Successful joint preservation of distal radius osteosarcoma by en bloc tumor excision and reconstruction using a tumor bearing frozen autograft: a case report
by: Takashi Higuchi, et al.
Published: (2018-03-01)

The accuracy of different FRAX tools in predicting fracture risk in Japan: A comparison study.
by: Gang Xu, et al.
Published: (2020-04-01)

A Radiological Scoring System for Differentiation between Enchondroma and Chondrosarcoma
by: Shinji Miwa, et al.
Published: (2021-07-01)

Osteoclasts in Osteosarcoma: Mechanisms, Interactions, and Therapeutic Prospects
by: Gao YM, et al.
Published: (2023-11-01)

Low-grade myofibroblastic sarcoma of the levator scapulae muscle: a case report and literature review
by: Hirotaka Yonezawa, et al.
Published: (2020-12-01)

Case report: Complete remission of bone metastasis from renal cell carcinoma in histopathological examination after treatment with immune checkpoint inhibitors
by: Yohei Asano, et al.
Published: (2022-09-01)

The usefulness of wide excision assisted by a computer navigation system and reconstruction using a frozen bone autograft for malignant acetabular bone tumors: a report of two cases
by: Kensaku Abe, et al.
Published: (2018-10-01)

Insufficiency fracture of the supra-acetabulum that required differentiation from a pathological fracture secondary to a malignant bone tumor: a case report
by: Sei Morinaga, et al.
Published: (2022-11-01)

Clinical characteristics of patients with undergoing unplanned excisions of malignant soft tissue tumors
by: Sei Morinaga, et al.
Published: (2021-11-01)

Clinical Outcomes of Soft Tissue Sarcoma around the Elbow Joint: A Retrospective Single Institution Study
by: Edelyn S. Azurin, et al.
Published: (2022-01-01)

Prognostic value of histological response to chemotherapy in osteosarcoma patients receiving tumor-bearing frozen autograft.
by: Shinji Miwa, et al.
Published: (2013-01-01)

The Therapeutic Effect and Clinical Outcome of Immune Checkpoint Inhibitors on Bone Metastasis in Advanced Non-Small-Cell Lung Cancer
by: Yohei Asano, et al.
Published: (2022-04-01)

Osteosarcoma-Derived Small Extracellular Vesicles Enhance Tumor Metastasis and Suppress Osteoclastogenesis by miR-146a-5p
by: Yoshihiro Araki, et al.
Published: (2021-05-01)

Graft Survivals after Reconstruction Using Tumor-Bearing Frozen Bone in the Extremities
by: Shinji Miwa, et al.
Published: (2023-08-01)

Caffeine citrate enhanced cisplatin antitumor effects in osteosarcoma and fibrosarcoma in vitro and in vivo
by: Kensaku Abe, et al.
Published: (2019-07-01)

Deep Learning Techniques for Quantiﬁcation of Tumour Necrosis in Post-neoadjuvant Chemotherapy Osteosarcoma Resection Specimens for Eﬀective Treatment Planning
by: T. S. Saleena, et al.
Published: (2023-04-01)

Late Recurrence of Osteosarcoma: A Report of Two Cases
by: Kentaro Igarashi, et al.
Published: (2014-12-01)

Characterization of Macrophages and Osteoclasts in the Osteosarcoma Tumor Microenvironment at Diagnosis: New Perspective for Osteosarcoma Treatment?
by: Anne Gomez-Brouchet, et al.
Published: (2021-01-01)

Novel predictors of immune checkpoint inhibitor response and prognosis in advanced non‐small‐cell lung cancer with bone metastasis
by: Yohei Asano, et al.
Published: (2023-06-01)

Factors Associated With Discharge Destination in Advanced Cancer Patients With Bone Metastasis in a Japanese Hospital
by: Katsuhiro Hayashi, et al.
Published: (2018-06-01)

Neoadjuvant and Adjuvant Chemotherapy in Osteosarcoma (The Experience of HORC in the Shariati Hospital)
by: Alimoghadam K, et al.
Published: (2004-07-01)

Neoadjuvant and Adjuvant Chemotherapy in Osteosarcoma (The Experience of HORC in the Shariati Hospital)
by: K Alimoghadam, et al.
Published: (2004-03-01)

Fibrinogen–Albumin Ratio Index Exhibits Predictive Value of Neoadjuvant Chemotherapy in Osteosarcoma
by: Li Z, et al.
Published: (2022-05-01)

The Combination of Olaratumab with Doxorubicin and Cisplatinum Regresses a Chemotherapy-Resistant Osteosarcoma in a Patient-Derived Orthotopic Xenograft Mouse Model
by: Takashi Higuchi, et al.
Published: (2019-09-01)

Recent Advances and Challenges in the Treatment of Rhabdomyosarcoma
by: Shinji Miwa, et al.
Published: (2020-07-01)

Therapeutic Targets and Emerging Treatments in Advanced Chondrosarcoma
by: Shinji Miwa, et al.
Published: (2022-01-01)

Surgical Site Infection after Bone Tumor Surgery: Risk Factors and New Preventive Techniques
by: Shinji Miwa, et al.
Published: (2022-09-01)

Osteosarcoma and Metastasis Associated Bone Degradation—A Tale of Osteoclast and Malignant Cell Cooperativity
by: Kirstine Sandal Nørregaard, et al.
Published: (2021-06-01)

The effect of specimen geometry on the mechanical behavior of trabecular bone specimens
by: Chou, Siaw Meng, et al.
Published: (2013)

Probing uniform and nonuniform charge ordering with polarized femtosecond optical pulses in geometrically frustrated θ-(BEDT-TTF)_{2}MZn(SCN)_{4} (M=Rb, Cs)
by: K. Nakagawa, et al.
Published: (2023-01-01)

Erratum: Probing uniform and nonuniform charge ordering with polarized femtosecond optical pulses in geometrically frustrated θ-(BEDT-TTF)_{2}MZn(SCN)_{4} (M=Rb, Cs) [Phys. Rev. Research 5, 013024 (2023)]
by: K. Nakagawa, et al.
Published: (2024-01-01)