Highly sensitive plasmonic paper substrate fabricated via amphiphilic polymer self-assembly in microdroplet for detection of emerging pharmaceutical pollutants
Abstract We report an innovative and facile approach to fabricating an ultrasensitive plasmonic paper substrate for surface-enhanced Raman spectroscopy (SERS). The approach exploits the self-assembling capability of poly(styrene-b-2-vinyl pyridine) block copolymers to form a thin film at the air-liq...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-03-01
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| Series: | Nano Convergence |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40580-024-00420-x |
| _version_ | 1797233387145003008 |
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| author | Mirkomil Sharipov Sarvar A. Kakhkhorov Salah M. Tawfik Shavkatjon Azizov Hong-Guo Liu Joong Ho Shin Yong-Ill Lee |
| author_facet | Mirkomil Sharipov Sarvar A. Kakhkhorov Salah M. Tawfik Shavkatjon Azizov Hong-Guo Liu Joong Ho Shin Yong-Ill Lee |
| author_sort | Mirkomil Sharipov |
| collection | DOAJ |
| description | Abstract We report an innovative and facile approach to fabricating an ultrasensitive plasmonic paper substrate for surface-enhanced Raman spectroscopy (SERS). The approach exploits the self-assembling capability of poly(styrene-b-2-vinyl pyridine) block copolymers to form a thin film at the air-liquid interface within the single microdroplet scale for the first time and the subsequent in situ growth of silver nanoparticles (AgNPs). The concentration of the block copolymer was found to play an essential role in stabilizing the droplets during the mass transfer phase and formation of silver nanoparticles, thus influencing the SERS signals. SEM analysis of the morphology of the plasmonic paper substrates revealed the formation of spherical AgNPs evenly distributed across the surface of the formed copolymer film with a size distribution of 47.5 nm. The resultant enhancement factor was calculated to be 1.2 × 107, and the detection limit of rhodamine 6G was as low as 48.9 pM. The nanohybridized plasmonic paper was successfully applied to detect two emerging pollutants—sildenafil and flibanserin—with LODs as low as 1.48 nM and 3.45 nM, respectively. Thus, this study offers new prospects for designing an affordable and readily available, yet highly sensitive, paper-based SERS substrate with the potential for development as a lab-on-a-chip device. |
| first_indexed | 2024-04-24T16:15:21Z |
| format | Article |
| id | doaj.art-4c9187670c6448cf868bed02265741be |
| institution | Directory Open Access Journal |
| issn | 2196-5404 |
| language | English |
| last_indexed | 2024-04-24T16:15:21Z |
| publishDate | 2024-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nano Convergence |
| spelling | doaj.art-4c9187670c6448cf868bed02265741be2024-03-31T11:28:41ZengSpringerOpenNano Convergence2196-54042024-03-0111111110.1186/s40580-024-00420-xHighly sensitive plasmonic paper substrate fabricated via amphiphilic polymer self-assembly in microdroplet for detection of emerging pharmaceutical pollutantsMirkomil Sharipov0Sarvar A. Kakhkhorov1Salah M. Tawfik2Shavkatjon Azizov3Hong-Guo Liu4Joong Ho Shin5Yong-Ill Lee6Anastro Laboratory, Institute of Basic Science, Changwon National UniversityAnastro Laboratory, Institute of Basic Science, Changwon National UniversityDepartment of Petrochemicals, Egyptian Petroleum Research InstituteAnastro Laboratory, Institute of Basic Science, Changwon National UniversityKey Laboratory for Colloid and Interface Chemistry of Education Ministry, Shandong UniversityDivision of Smart Healthcare, College of Information Technology and Convergence, Pukyong National UniversityAnastro Laboratory, Institute of Basic Science, Changwon National UniversityAbstract We report an innovative and facile approach to fabricating an ultrasensitive plasmonic paper substrate for surface-enhanced Raman spectroscopy (SERS). The approach exploits the self-assembling capability of poly(styrene-b-2-vinyl pyridine) block copolymers to form a thin film at the air-liquid interface within the single microdroplet scale for the first time and the subsequent in situ growth of silver nanoparticles (AgNPs). The concentration of the block copolymer was found to play an essential role in stabilizing the droplets during the mass transfer phase and formation of silver nanoparticles, thus influencing the SERS signals. SEM analysis of the morphology of the plasmonic paper substrates revealed the formation of spherical AgNPs evenly distributed across the surface of the formed copolymer film with a size distribution of 47.5 nm. The resultant enhancement factor was calculated to be 1.2 × 107, and the detection limit of rhodamine 6G was as low as 48.9 pM. The nanohybridized plasmonic paper was successfully applied to detect two emerging pollutants—sildenafil and flibanserin—with LODs as low as 1.48 nM and 3.45 nM, respectively. Thus, this study offers new prospects for designing an affordable and readily available, yet highly sensitive, paper-based SERS substrate with the potential for development as a lab-on-a-chip device.https://doi.org/10.1186/s40580-024-00420-xSurface-enhanced Raman scatteringAir/liquid interfaceMicrodropletSelf-assemblyEmerging pollutants |
| spellingShingle | Mirkomil Sharipov Sarvar A. Kakhkhorov Salah M. Tawfik Shavkatjon Azizov Hong-Guo Liu Joong Ho Shin Yong-Ill Lee Highly sensitive plasmonic paper substrate fabricated via amphiphilic polymer self-assembly in microdroplet for detection of emerging pharmaceutical pollutants Nano Convergence Surface-enhanced Raman scattering Air/liquid interface Microdroplet Self-assembly Emerging pollutants |
| title | Highly sensitive plasmonic paper substrate fabricated via amphiphilic polymer self-assembly in microdroplet for detection of emerging pharmaceutical pollutants |
| title_full | Highly sensitive plasmonic paper substrate fabricated via amphiphilic polymer self-assembly in microdroplet for detection of emerging pharmaceutical pollutants |
| title_fullStr | Highly sensitive plasmonic paper substrate fabricated via amphiphilic polymer self-assembly in microdroplet for detection of emerging pharmaceutical pollutants |
| title_full_unstemmed | Highly sensitive plasmonic paper substrate fabricated via amphiphilic polymer self-assembly in microdroplet for detection of emerging pharmaceutical pollutants |
| title_short | Highly sensitive plasmonic paper substrate fabricated via amphiphilic polymer self-assembly in microdroplet for detection of emerging pharmaceutical pollutants |
| title_sort | highly sensitive plasmonic paper substrate fabricated via amphiphilic polymer self assembly in microdroplet for detection of emerging pharmaceutical pollutants |
| topic | Surface-enhanced Raman scattering Air/liquid interface Microdroplet Self-assembly Emerging pollutants |
| url | https://doi.org/10.1186/s40580-024-00420-x |
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