The Potential Role of Nutrition in Lung Cancer Establishment and Progression
Lung cancer is a devastating disease with a high incidence and low survival rates, so recent studies have focused on analyzing the risk factors that might prevent this disease from developing or have protective/therapeutic effects. Nutrition is an important key factor in the prevention and treatment...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/2/270 |
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| author | Chiara Porro Maria Ester La Torre Nicola Tartaglia Tarek Benameur Mario Santini Antonio Ambrosi Giovanni Messina Giuseppe Cibelli Alfonso Fiorelli Rita Polito Gaetana Messina |
| author_facet | Chiara Porro Maria Ester La Torre Nicola Tartaglia Tarek Benameur Mario Santini Antonio Ambrosi Giovanni Messina Giuseppe Cibelli Alfonso Fiorelli Rita Polito Gaetana Messina |
| author_sort | Chiara Porro |
| collection | DOAJ |
| description | Lung cancer is a devastating disease with a high incidence and low survival rates, so recent studies have focused on analyzing the risk factors that might prevent this disease from developing or have protective/therapeutic effects. Nutrition is an important key factor in the prevention and treatment of lung cancer. Various factors appear to be involved in the development of the latter, such as cigarette smoking or certain external environmental factors. The increase in oxidative stress is therefore an integral part of the carcinogenesis process. The biological role of bioactive factors derived from adipose tissue, mainly adipokines, is implicated in various cancers, and an increasing body of evidence has shown that certain adipocytokines contribute to the development, progression and prognosis of lung cancer. Not all adipokines stimulate tumor growth; in fact, adiponectin inhibits carcinogenesis by regulating both cell growth and the levels of inflammatory cytokines. Adiponectin expression is deregulated in several cancer types. Many nutritional factors have been shown to increase adiponectin levels and therefore could be used as a new therapeutic strategy for combating lung cancer. In addition, foods with antioxidant and anti-inflammatory properties play a key role in the prevention of many human diseases, including lung cancer. The purpose of this review is to analyze the role of diet in lung cancer in order to recommend dietary habit and lifestyle changes to prevent or treat this pathology. |
| first_indexed | 2024-03-09T21:34:14Z |
| format | Article |
| id | doaj.art-4c934d2a63d3489b8377869f6c51047e |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T21:34:14Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-4c934d2a63d3489b8377869f6c51047e2023-11-23T20:46:44ZengMDPI AGLife2075-17292022-02-0112227010.3390/life12020270The Potential Role of Nutrition in Lung Cancer Establishment and ProgressionChiara Porro0Maria Ester La Torre1Nicola Tartaglia2Tarek Benameur3Mario Santini4Antonio Ambrosi5Giovanni Messina6Giuseppe Cibelli7Alfonso Fiorelli8Rita Polito9Gaetana Messina10Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Medical Additionally, Surgical Sciences, University of Foggia, 71100 Foggia, ItalyDepartment of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Translational Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Medical Additionally, Surgical Sciences, University of Foggia, 71100 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Translational Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Translational Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyLung cancer is a devastating disease with a high incidence and low survival rates, so recent studies have focused on analyzing the risk factors that might prevent this disease from developing or have protective/therapeutic effects. Nutrition is an important key factor in the prevention and treatment of lung cancer. Various factors appear to be involved in the development of the latter, such as cigarette smoking or certain external environmental factors. The increase in oxidative stress is therefore an integral part of the carcinogenesis process. The biological role of bioactive factors derived from adipose tissue, mainly adipokines, is implicated in various cancers, and an increasing body of evidence has shown that certain adipocytokines contribute to the development, progression and prognosis of lung cancer. Not all adipokines stimulate tumor growth; in fact, adiponectin inhibits carcinogenesis by regulating both cell growth and the levels of inflammatory cytokines. Adiponectin expression is deregulated in several cancer types. Many nutritional factors have been shown to increase adiponectin levels and therefore could be used as a new therapeutic strategy for combating lung cancer. In addition, foods with antioxidant and anti-inflammatory properties play a key role in the prevention of many human diseases, including lung cancer. The purpose of this review is to analyze the role of diet in lung cancer in order to recommend dietary habit and lifestyle changes to prevent or treat this pathology.https://www.mdpi.com/2075-1729/12/2/270lung cancerobesityhealthy lifestylecorrect nutritionoxidative stressinflammation |
| spellingShingle | Chiara Porro Maria Ester La Torre Nicola Tartaglia Tarek Benameur Mario Santini Antonio Ambrosi Giovanni Messina Giuseppe Cibelli Alfonso Fiorelli Rita Polito Gaetana Messina The Potential Role of Nutrition in Lung Cancer Establishment and Progression Life lung cancer obesity healthy lifestyle correct nutrition oxidative stress inflammation |
| title | The Potential Role of Nutrition in Lung Cancer Establishment and Progression |
| title_full | The Potential Role of Nutrition in Lung Cancer Establishment and Progression |
| title_fullStr | The Potential Role of Nutrition in Lung Cancer Establishment and Progression |
| title_full_unstemmed | The Potential Role of Nutrition in Lung Cancer Establishment and Progression |
| title_short | The Potential Role of Nutrition in Lung Cancer Establishment and Progression |
| title_sort | potential role of nutrition in lung cancer establishment and progression |
| topic | lung cancer obesity healthy lifestyle correct nutrition oxidative stress inflammation |
| url | https://www.mdpi.com/2075-1729/12/2/270 |
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