Biodistribution and radiation dosimetry of [64Cu]copper dichloride: first-in-human study in healthy volunteers
Abstract Background In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is overexpressed in a variety of cancer cells. Limi...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2017-12-01
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| Series: | EJNMMI Research |
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| Online Access: | http://link.springer.com/article/10.1186/s13550-017-0346-4 |
| _version_ | 1818932947905937408 |
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| author | M.A. Avila-Rodriguez C. Rios J. Carrasco-Hernandez J. C. Manrique-Arias R. Martinez-Hernandez F. O. García-Pérez A. R. Jalilian E. Martinez-Rodriguez M. E. Romero-Piña A. Diaz-Ruiz |
| author_facet | M.A. Avila-Rodriguez C. Rios J. Carrasco-Hernandez J. C. Manrique-Arias R. Martinez-Hernandez F. O. García-Pérez A. R. Jalilian E. Martinez-Rodriguez M. E. Romero-Piña A. Diaz-Ruiz |
| author_sort | M.A. Avila-Rodriguez |
| collection | DOAJ |
| description | Abstract Background In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is overexpressed in a variety of cancer cells. Limited human biodistribution and radiation dosimetry data is available for this tracer. The aim of this research was to determine the biodistribution and estimate the radiation dosimetry of [64Cu]CuCl2, using whole-body (WB) PET scans in healthy volunteers. Six healthy volunteers were included in this study (3 women and 3 men, mean age ± SD, 54.3 ± 8.6 years; mean weight ± SD, 77.2 ± 12.4 kg). After intravenous injection of the tracer (4.0 MBq/kg), three consecutive WB emission scans were acquired at 5, 30, and 60 min after injection. Additional scans were acquired at 5, 9, and 24 h post-injection. Low-dose CT scan without contrast was used for anatomic localization and attenuation correction. OLINDA/EXM software was used to calculate human radiation doses using the reference adult model. Results The highest uptake was in the liver, followed by lower and upper large intestine walls, and pancreas, in descending order. Urinary excretion was negligible. The critical organ was liver with a mean absorbed dose of 310 ± 67 μGy/MBq for men and 421 ± 56 μGy/MBq for women, while the mean WB effective doses were 51.2 ± 3.0 and 61.8 ± 5.2 μSv/MBq for men and women, respectively. Conclusions To the best of our knowledge, this is the first report on biodistribution and radiation dosimetry of [64Cu]CuCl2 in healthy volunteers. Measured absorbed doses and effective doses are higher than previously reported doses estimated with biodistribution data from patients with prostate cancer, a difference that could be explained not just due to altered biodistribution in cancer patients compared to healthy volunteers but most likely due to the differences in the analysis technique and assumptions in the dose calculation. |
| first_indexed | 2024-12-20T04:40:35Z |
| format | Article |
| id | doaj.art-4c9532160aa34751bef3bef57434c679 |
| institution | Directory Open Access Journal |
| issn | 2191-219X |
| language | English |
| last_indexed | 2024-12-20T04:40:35Z |
| publishDate | 2017-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Research |
| spelling | doaj.art-4c9532160aa34751bef3bef57434c6792022-12-21T19:53:08ZengSpringerOpenEJNMMI Research2191-219X2017-12-01711710.1186/s13550-017-0346-4Biodistribution and radiation dosimetry of [64Cu]copper dichloride: first-in-human study in healthy volunteersM.A. Avila-Rodriguez0C. Rios1J. Carrasco-Hernandez2J. C. Manrique-Arias3R. Martinez-Hernandez4F. O. García-Pérez5A. R. Jalilian6E. Martinez-Rodriguez7M. E. Romero-Piña8A. Diaz-Ruiz9Unidad Radiofarmacia-Ciclotrón, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de MéxicoDepartamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez S.S.AUnidad Radiofarmacia-Ciclotrón, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de MéxicoUnidad Radiofarmacia-Ciclotrón, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de MéxicoDepartamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez S.S.ADepartamento de Medicina Nuclear, Instituto Nacional de CancerologíaDepartment of Nuclear Sciences and Applications, International Atomic Energy Agency (IAEA)Departamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez S.S.ADepartamento de Medicina Nuclear, Instituto Nacional de CancerologíaDepartamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez S.S.AAbstract Background In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is overexpressed in a variety of cancer cells. Limited human biodistribution and radiation dosimetry data is available for this tracer. The aim of this research was to determine the biodistribution and estimate the radiation dosimetry of [64Cu]CuCl2, using whole-body (WB) PET scans in healthy volunteers. Six healthy volunteers were included in this study (3 women and 3 men, mean age ± SD, 54.3 ± 8.6 years; mean weight ± SD, 77.2 ± 12.4 kg). After intravenous injection of the tracer (4.0 MBq/kg), three consecutive WB emission scans were acquired at 5, 30, and 60 min after injection. Additional scans were acquired at 5, 9, and 24 h post-injection. Low-dose CT scan without contrast was used for anatomic localization and attenuation correction. OLINDA/EXM software was used to calculate human radiation doses using the reference adult model. Results The highest uptake was in the liver, followed by lower and upper large intestine walls, and pancreas, in descending order. Urinary excretion was negligible. The critical organ was liver with a mean absorbed dose of 310 ± 67 μGy/MBq for men and 421 ± 56 μGy/MBq for women, while the mean WB effective doses were 51.2 ± 3.0 and 61.8 ± 5.2 μSv/MBq for men and women, respectively. Conclusions To the best of our knowledge, this is the first report on biodistribution and radiation dosimetry of [64Cu]CuCl2 in healthy volunteers. Measured absorbed doses and effective doses are higher than previously reported doses estimated with biodistribution data from patients with prostate cancer, a difference that could be explained not just due to altered biodistribution in cancer patients compared to healthy volunteers but most likely due to the differences in the analysis technique and assumptions in the dose calculation.http://link.springer.com/article/10.1186/s13550-017-0346-4Copper-64[64Cu]CuCl2Copper biodistributionRadiation dosimetryTheranostics |
| spellingShingle | M.A. Avila-Rodriguez C. Rios J. Carrasco-Hernandez J. C. Manrique-Arias R. Martinez-Hernandez F. O. García-Pérez A. R. Jalilian E. Martinez-Rodriguez M. E. Romero-Piña A. Diaz-Ruiz Biodistribution and radiation dosimetry of [64Cu]copper dichloride: first-in-human study in healthy volunteers EJNMMI Research Copper-64 [64Cu]CuCl2 Copper biodistribution Radiation dosimetry Theranostics |
| title | Biodistribution and radiation dosimetry of [64Cu]copper dichloride: first-in-human study in healthy volunteers |
| title_full | Biodistribution and radiation dosimetry of [64Cu]copper dichloride: first-in-human study in healthy volunteers |
| title_fullStr | Biodistribution and radiation dosimetry of [64Cu]copper dichloride: first-in-human study in healthy volunteers |
| title_full_unstemmed | Biodistribution and radiation dosimetry of [64Cu]copper dichloride: first-in-human study in healthy volunteers |
| title_short | Biodistribution and radiation dosimetry of [64Cu]copper dichloride: first-in-human study in healthy volunteers |
| title_sort | biodistribution and radiation dosimetry of 64cu copper dichloride first in human study in healthy volunteers |
| topic | Copper-64 [64Cu]CuCl2 Copper biodistribution Radiation dosimetry Theranostics |
| url | http://link.springer.com/article/10.1186/s13550-017-0346-4 |
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