Therapeutic potential of toosendanin: Novel applications of an old ascaris repellent as a drug candidate
Toosendanin (TSN), extracted from Melia. toosendan Sieb.et Zucc. and Melia. azedarach L., has been developed into an ascaris repellent in China. However, with the improvement of public health protection, the incidence of ascariasis has been reduced considerably, resulting in limited medical applicat...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223013392 |
| _version_ | 1797660569839337472 |
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| author | Minghao Hu Min Xu Yuchen Chen Zhangkai Ye Shunpeng Zhu Jia Cai Mengxue Zhang Chi Zhang Ruizhen Huang Qiang Ye Hui Ao |
| author_facet | Minghao Hu Min Xu Yuchen Chen Zhangkai Ye Shunpeng Zhu Jia Cai Mengxue Zhang Chi Zhang Ruizhen Huang Qiang Ye Hui Ao |
| author_sort | Minghao Hu |
| collection | DOAJ |
| description | Toosendanin (TSN), extracted from Melia. toosendan Sieb.et Zucc. and Melia. azedarach L., has been developed into an ascaris repellent in China. However, with the improvement of public health protection, the incidence of ascariasis has been reduced considerably, resulting in limited medical application of TSN. Therefore, it is questionable whether this old ascaris repellent can develop into a drug candidate. Modern studies have shown that TSN has strong pharmacological activities, including anti-tumor, anti-botulinum, anti-viral and anti-parasitic potentials. It also can regulate fat formation and improve inflammation. These researches indicate that TSN has great potential to be developed into a corresponding medical product. In order to better development and application of TSN, the availability, pharmacodynamics, pharmacokinetics and toxicology of TSN are summarized systematically. In addition, this review discusses shortcomings in the current researches and provides useful suggestions about how TSN developed into a drug candidate. Therefore, this paper illustrates the possibility of developing TSN as a medical product, aimed to provide directions for the clinical application and further research of TSN. |
| first_indexed | 2024-03-11T18:31:49Z |
| format | Article |
| id | doaj.art-4c99a7e2b2e54ab48c6749be273193d8 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T18:31:49Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-4c99a7e2b2e54ab48c6749be273193d82023-10-13T11:03:01ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-11-01167115541Therapeutic potential of toosendanin: Novel applications of an old ascaris repellent as a drug candidateMinghao Hu0Min Xu1Yuchen Chen2Zhangkai Ye3Shunpeng Zhu4Jia Cai5Mengxue Zhang6Chi Zhang7Ruizhen Huang8Qiang Ye9Hui Ao10State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, ChinaXinjiang Normal University, Urumqi 830017, Xinjiang, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, ChinaFirst School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, ChinaSchool of health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, ChinaAffiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China; Corresponding author.State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, China; Corresponding authors at: State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, China; Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, China; Corresponding authors at: State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, ChinaToosendanin (TSN), extracted from Melia. toosendan Sieb.et Zucc. and Melia. azedarach L., has been developed into an ascaris repellent in China. However, with the improvement of public health protection, the incidence of ascariasis has been reduced considerably, resulting in limited medical application of TSN. Therefore, it is questionable whether this old ascaris repellent can develop into a drug candidate. Modern studies have shown that TSN has strong pharmacological activities, including anti-tumor, anti-botulinum, anti-viral and anti-parasitic potentials. It also can regulate fat formation and improve inflammation. These researches indicate that TSN has great potential to be developed into a corresponding medical product. In order to better development and application of TSN, the availability, pharmacodynamics, pharmacokinetics and toxicology of TSN are summarized systematically. In addition, this review discusses shortcomings in the current researches and provides useful suggestions about how TSN developed into a drug candidate. Therefore, this paper illustrates the possibility of developing TSN as a medical product, aimed to provide directions for the clinical application and further research of TSN.http://www.sciencedirect.com/science/article/pii/S0753332223013392ToosendaninAvailabilityPharmacological activitiesPharmacokineticsToxicity |
| spellingShingle | Minghao Hu Min Xu Yuchen Chen Zhangkai Ye Shunpeng Zhu Jia Cai Mengxue Zhang Chi Zhang Ruizhen Huang Qiang Ye Hui Ao Therapeutic potential of toosendanin: Novel applications of an old ascaris repellent as a drug candidate Biomedicine & Pharmacotherapy Toosendanin Availability Pharmacological activities Pharmacokinetics Toxicity |
| title | Therapeutic potential of toosendanin: Novel applications of an old ascaris repellent as a drug candidate |
| title_full | Therapeutic potential of toosendanin: Novel applications of an old ascaris repellent as a drug candidate |
| title_fullStr | Therapeutic potential of toosendanin: Novel applications of an old ascaris repellent as a drug candidate |
| title_full_unstemmed | Therapeutic potential of toosendanin: Novel applications of an old ascaris repellent as a drug candidate |
| title_short | Therapeutic potential of toosendanin: Novel applications of an old ascaris repellent as a drug candidate |
| title_sort | therapeutic potential of toosendanin novel applications of an old ascaris repellent as a drug candidate |
| topic | Toosendanin Availability Pharmacological activities Pharmacokinetics Toxicity |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223013392 |
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