Cell‐to‐cell communication: microRNAs as hormones
Mammalian cells can release different types of extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies. Accumulating evidence suggests that EVs play a role in cell‐to‐cell communication within the tumor microenvironment. EVs’ components, such as proteins, noncoding RNAs...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-12-01
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| Series: | Molecular Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/1878-0261.12144 |
| _version_ | 1818480517293539328 |
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| author | Recep Bayraktar Katrien Van Roosbroeck George A. Calin |
| author_facet | Recep Bayraktar Katrien Van Roosbroeck George A. Calin |
| author_sort | Recep Bayraktar |
| collection | DOAJ |
| description | Mammalian cells can release different types of extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies. Accumulating evidence suggests that EVs play a role in cell‐to‐cell communication within the tumor microenvironment. EVs’ components, such as proteins, noncoding RNAs [microRNAs (miRNAs), and long noncoding RNAs (lncRNAs)], messenger RNAs (mRNAs), DNA, and lipids, can mediate paracrine signaling in the tumor microenvironment. Recently, miRNAs encapsulated in secreted EVs have been identified in the extracellular space. Mature miRNAs that participate in intercellular communication are released from most cells, often within EVs, and disseminate through the extracellular fluid to reach remote target cells, including tumor cells, whose phenotypes they can influence by regulating mRNA and protein expression either as tumor suppressors or as oncogenes, depending on their targets. In this review, we discuss the roles of miRNAs in intercellular communication, the biological function of extracellular miRNAs, and their potential applications for diagnosis and therapeutics. We will give examples of miRNAs that behave as hormones. |
| first_indexed | 2024-12-10T11:24:43Z |
| format | Article |
| id | doaj.art-4c99a852f9124fa6b3c511feb90dcaa9 |
| institution | Directory Open Access Journal |
| issn | 1574-7891 1878-0261 |
| language | English |
| last_indexed | 2024-12-10T11:24:43Z |
| publishDate | 2017-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Oncology |
| spelling | doaj.art-4c99a852f9124fa6b3c511feb90dcaa92022-12-22T01:50:47ZengWileyMolecular Oncology1574-78911878-02612017-12-0111121673168610.1002/1878-0261.12144Cell‐to‐cell communication: microRNAs as hormonesRecep Bayraktar0Katrien Van Roosbroeck1George A. Calin2Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX USADepartment of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX USADepartment of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston TX USAMammalian cells can release different types of extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies. Accumulating evidence suggests that EVs play a role in cell‐to‐cell communication within the tumor microenvironment. EVs’ components, such as proteins, noncoding RNAs [microRNAs (miRNAs), and long noncoding RNAs (lncRNAs)], messenger RNAs (mRNAs), DNA, and lipids, can mediate paracrine signaling in the tumor microenvironment. Recently, miRNAs encapsulated in secreted EVs have been identified in the extracellular space. Mature miRNAs that participate in intercellular communication are released from most cells, often within EVs, and disseminate through the extracellular fluid to reach remote target cells, including tumor cells, whose phenotypes they can influence by regulating mRNA and protein expression either as tumor suppressors or as oncogenes, depending on their targets. In this review, we discuss the roles of miRNAs in intercellular communication, the biological function of extracellular miRNAs, and their potential applications for diagnosis and therapeutics. We will give examples of miRNAs that behave as hormones.https://doi.org/10.1002/1878-0261.12144cell–cell communicationcirculating miRNAsexosomesextracellular vesiclesmicroRNAstumor microenvironment |
| spellingShingle | Recep Bayraktar Katrien Van Roosbroeck George A. Calin Cell‐to‐cell communication: microRNAs as hormones Molecular Oncology cell–cell communication circulating miRNAs exosomes extracellular vesicles microRNAs tumor microenvironment |
| title | Cell‐to‐cell communication: microRNAs as hormones |
| title_full | Cell‐to‐cell communication: microRNAs as hormones |
| title_fullStr | Cell‐to‐cell communication: microRNAs as hormones |
| title_full_unstemmed | Cell‐to‐cell communication: microRNAs as hormones |
| title_short | Cell‐to‐cell communication: microRNAs as hormones |
| title_sort | cell to cell communication micrornas as hormones |
| topic | cell–cell communication circulating miRNAs exosomes extracellular vesicles microRNAs tumor microenvironment |
| url | https://doi.org/10.1002/1878-0261.12144 |
| work_keys_str_mv | AT recepbayraktar celltocellcommunicationmicrornasashormones AT katrienvanroosbroeck celltocellcommunicationmicrornasashormones AT georgeacalin celltocellcommunicationmicrornasashormones |