The Relation between Mean Platelet Volume/Platelet Count Ratio and Prognostic Factors in Patients with Advanced Non-Small Cell Lung Cancer
Background: Identifying simple and reliable prognostic indicators in non-small cell lung cancer (NSCLC) is important to optimize its management. The mean platelet volume/platelet count (MPV/PC) ratio may be of prognostic value in some clinical conditions including NSCLC.<br />Aim: To investiga...
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| Format: | Article |
| Language: | English |
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Kasr Al-Ainy Center of Clinical Oncology and Nuclear Medicine
2016-06-01
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| Series: | Research in Oncology |
| Subjects: | |
| Online Access: | https://resoncol.journals.ekb.eg/article_589_1e5a673ee1ec674166cdbf3eaddd8e28.pdf |
| _version_ | 1818577549507166208 |
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| author | Amal Ibrahim Ola Abdel Fattah |
| author_facet | Amal Ibrahim Ola Abdel Fattah |
| author_sort | Amal Ibrahim |
| collection | DOAJ |
| description | Background: Identifying simple and reliable prognostic indicators in non-small cell lung cancer (NSCLC) is important to optimize its management. The mean platelet volume/platelet count (MPV/PC) ratio may be of prognostic value in some clinical conditions including NSCLC.<br />Aim: To investigate the relationship between MPV/PC ratio and some important prognostic factors in Egyptian NSCLC patients.<br />Methods: Retrospective study that included 69 patients with stage III/IV NSCLC in the period from January 2010 to December 2012. The complete blood picture done before starting treatment was the one considered for the calculation of MPV/PC. The relation between MPV/PC ratio and patients and disease characteristics was studied.<br />Results: More advanced stage was associated with lower average MPV/PC ratio. The average MPV/PC ratio was 0.45963 (95%CI: 0.38829- 0.53098) in patients with stage IIIA, 0.33873 (95%CI: 0.2854-0.39208) in stage IIIB and 0.32752 (95%CI: 0.28642- 0.36862) in stage IV (p=0.015).<br />Similarly, higher Eastern Cooperative Oncology Group performance status score was associated with lower MPV/PC ratio. The average MPV/PC ratio was 0.40949 (95%CI: 0.34959 – 0.46939) in patients with ECOG 1, 0.36369 (95%CI: 0.31009- 0.41724) in ECOG 2 and 0.28378 (95%CI: 0.24898 -0.31857) in ECOG 3 (p=0.004). Older patients had a significantly lower MPV/PC ratio (p=0.043).<br />Conclusion: Low MPV/PC is associated with poor prognostic factors in NSCLC such as advanced stage and poor performance status. Future clinical studies to evaluate the prognostic value of MPV/PC ration in NSCLC are warranted. |
| first_indexed | 2024-12-16T06:31:41Z |
| format | Article |
| id | doaj.art-4c99ab31e1fe451f9b4468e990b58c4e |
| institution | Directory Open Access Journal |
| issn | 2357-0687 2357-0695 |
| language | English |
| last_indexed | 2024-12-16T06:31:41Z |
| publishDate | 2016-06-01 |
| publisher | Kasr Al-Ainy Center of Clinical Oncology and Nuclear Medicine |
| record_format | Article |
| series | Research in Oncology |
| spelling | doaj.art-4c99ab31e1fe451f9b4468e990b58c4e2022-12-21T22:40:52ZengKasr Al-Ainy Center of Clinical Oncology and Nuclear MedicineResearch in Oncology2357-06872357-06952016-06-01121151910.21608/resoncol.2016.589589The Relation between Mean Platelet Volume/Platelet Count Ratio and Prognostic Factors in Patients with Advanced Non-Small Cell Lung CancerAmal Ibrahim0Ola Abdel Fattah1Department of Clinical Oncology, Faculty of Medicine, Assiut University, Assiut, EgyptDepartment of Clinical Oncology, Faculty of Medicine, Assiut University, Assiut, EgyptBackground: Identifying simple and reliable prognostic indicators in non-small cell lung cancer (NSCLC) is important to optimize its management. The mean platelet volume/platelet count (MPV/PC) ratio may be of prognostic value in some clinical conditions including NSCLC.<br />Aim: To investigate the relationship between MPV/PC ratio and some important prognostic factors in Egyptian NSCLC patients.<br />Methods: Retrospective study that included 69 patients with stage III/IV NSCLC in the period from January 2010 to December 2012. The complete blood picture done before starting treatment was the one considered for the calculation of MPV/PC. The relation between MPV/PC ratio and patients and disease characteristics was studied.<br />Results: More advanced stage was associated with lower average MPV/PC ratio. The average MPV/PC ratio was 0.45963 (95%CI: 0.38829- 0.53098) in patients with stage IIIA, 0.33873 (95%CI: 0.2854-0.39208) in stage IIIB and 0.32752 (95%CI: 0.28642- 0.36862) in stage IV (p=0.015).<br />Similarly, higher Eastern Cooperative Oncology Group performance status score was associated with lower MPV/PC ratio. The average MPV/PC ratio was 0.40949 (95%CI: 0.34959 – 0.46939) in patients with ECOG 1, 0.36369 (95%CI: 0.31009- 0.41724) in ECOG 2 and 0.28378 (95%CI: 0.24898 -0.31857) in ECOG 3 (p=0.004). Older patients had a significantly lower MPV/PC ratio (p=0.043).<br />Conclusion: Low MPV/PC is associated with poor prognostic factors in NSCLC such as advanced stage and poor performance status. Future clinical studies to evaluate the prognostic value of MPV/PC ration in NSCLC are warranted.https://resoncol.journals.ekb.eg/article_589_1e5a673ee1ec674166cdbf3eaddd8e28.pdfnon-small cell lung cancerprognosisplatelet volume/platelet count ratio |
| spellingShingle | Amal Ibrahim Ola Abdel Fattah The Relation between Mean Platelet Volume/Platelet Count Ratio and Prognostic Factors in Patients with Advanced Non-Small Cell Lung Cancer Research in Oncology non-small cell lung cancer prognosis platelet volume/platelet count ratio |
| title | The Relation between Mean Platelet Volume/Platelet Count Ratio and Prognostic Factors in Patients with Advanced Non-Small Cell Lung Cancer |
| title_full | The Relation between Mean Platelet Volume/Platelet Count Ratio and Prognostic Factors in Patients with Advanced Non-Small Cell Lung Cancer |
| title_fullStr | The Relation between Mean Platelet Volume/Platelet Count Ratio and Prognostic Factors in Patients with Advanced Non-Small Cell Lung Cancer |
| title_full_unstemmed | The Relation between Mean Platelet Volume/Platelet Count Ratio and Prognostic Factors in Patients with Advanced Non-Small Cell Lung Cancer |
| title_short | The Relation between Mean Platelet Volume/Platelet Count Ratio and Prognostic Factors in Patients with Advanced Non-Small Cell Lung Cancer |
| title_sort | relation between mean platelet volume platelet count ratio and prognostic factors in patients with advanced non small cell lung cancer |
| topic | non-small cell lung cancer prognosis platelet volume/platelet count ratio |
| url | https://resoncol.journals.ekb.eg/article_589_1e5a673ee1ec674166cdbf3eaddd8e28.pdf |
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