Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport

Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport

Summary: In schizophrenia (SCZ), neurons in the brain tend to undergo gross morphological changes, but the related molecular mechanism remains largely elusive. Using Kif3b+/− mice as a model with SCZ-like behaviors, we found that a high-betaine diet can significantly alleviate schizophrenic traits r...

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Bibliographic Details
Main Authors: Shogo Yoshihara, Xuguang Jiang, Momo Morikawa, Tadayuki Ogawa, Sotaro Ichinose, Hirooki Yabe, Akiyoshi Kakita, Manabu Toyoshima, Yasuto Kunii, Takeo Yoshikawa, Yosuke Tanaka, Nobutaka Hirokawa
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
schizophrenia
betaine
CRMP2
carbonylation
actin dynamics
kinesin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002850

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