Irradiation combined with PD-L1−/− and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation

Irradiation combined with PD-L1−/− and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation

Summary: Radiotherapy combined with immune checkpoint blockade has gradually revealed the superiority in the antitumor therapy; however, the contribution of host PD-L1 remains elusive. In this study, we found that the activation of CD8+ T cells was strikingly increased in both irradiated PD-L1-expre...

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Bibliographic Details
Main Authors: Xinrui Zhao, Songling Hu, Liang Zeng, Xinglong Liu, Yimeng Song, Yuhong Zhang, Qianping Chen, Yang Bai, Jianghong Zhang, Haowen Zhang, Yan Pan, Chunlin Shao
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:iScience
Subjects:
microenvironment
radiation biology
immune response
cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222009622

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